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Medicinal Chemistry Residential School 2019

The Royal Society of Chemistry Medicinal Chemistry Residential School is designed for graduate and post-doctoral chemists and will take place at Loughborough University from 2-7 June 2019.

Register now!

The meeting will cover topics of interest to drug discovery researchers, helping to increase understanding of the factors governing modern drug discovery from the initial concept through to translational science and intellectual property. Established since 1981, our Residential School has trained many of the world’s leading medicinal chemists working in the pharmaceutical industry and academic research institutes.


Examples of feedback from previous Residential School Delegates:

“It was an extremely worthwhile experience that greatly clarified a haze of vague knowledge, as well as taught me things I’ve never thought about before.”

“Great range of topics with a good balance of lectures and tutorials. I really enjoyed the week and definitely feel that I have learnt a lot. Would recommend to everyone.”

If you are interested in the event find out more information and register here.

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2019 MedChemComm Emerging Investigator Lectureship Winner

Congratulations to Professor Amanda Hargrove from Duke University, USA, the recipient of the 2019 MedChemComm Emerging Investigator Lectureship!

The Lectureship was open to any candidate who received their PhD in 2009 or later and have made a significant contribution to medicinal chemistry in their early career. The MedChemComm Editorial Board then voted on a short-list of nominations.

Many congratulations to Prof. Hargrove for winning the lectureship.

About Amanda

Amanda E. Hargrove, Ph.D. joined the faculty at Duke University in 2013 as an Assistant Professor of Chemistry following an NIH postdoctoral fellowship with Professor Peter B. Dervan at the California Institute of Technology and doctoral research at the University of Texas at Austin with Professors Eric V. Anslyn and Jonathan L. Sessler. Her research group at Duke focuses on developing small molecule probes to investigate the structure and function of RNA molecules relevant to human disease. You can find out more about their research by visiting the laboratory webpage.

Prof. Hargrove holds a secondary appointment in the Biochemistry Department and membership in the Duke Cancer Institute, Duke Cellular and Molecular Biology Program, and the Center for Biological and Tissue Engineering. Her recent honors include the ChemComm Emerging Investigator Lectureship, NSF CAREER Award, Cottrell Scholar Award, and the Prostate Cancer Young Investigator Award.

For a selection of her excellent research, please see some of Prof. Hargrove’s recent works below.

 

Fluorescent peptide displacement as a general assay for screening small molecule libraries against RNA

Org. Biomol. Chem., 2019, 17, 1778-1786

Part of the themed collection: New Talent

 

Sensing the impact of environment on small molecule differentiation of RNA sequences

Chem. Commun., 2017, 53, 13363-13366

Part of the themed collection: Chemosensors and Molecular Logic

 

Amiloride as a new RNA-binding scaffold with activity against HIV-1 TAR

Med. Chem. Commun., 2017,8, 1022-1036

Part of the themed collection: 2017 Hot Articles in MedChemComm

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MedChemComm welcomes Professor Jayanta Haldar to the Editorial Board

We are delighted to welcome to the team Professor Jayanta Haldar of the Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bangalore, India.

Jayanta studied at Presidency College, University of Calcutta before moving to the Indian Institute of Science, Bangalore for an M.Sc. and Ph.D.. In 2004, he took up a postdoctoral position at the Massachusetts Institute of Technology, USA with Alexander Klibanov. Subsequently, Jayanta returned to India to take up an Assistant Professor position at JNCASR, his current faculty, where he was made Associate Professor in 2015.

Professor Haldar’s group specializes in the development of novel antimicrobial therapeutics, coatings and surfaces, alongside novel nano-delivery systems for drugs. To find out more about his research, take a look at the group webpage, or read a few of his many publications:

 

Selectively targeting bacteria by tuning the molecular design of membrane-active peptidomimetic amphiphiles

Chem. Commun., 2018,54, 4943-4946, DOI: 10.1039/C8CC01926F

 

L-Lysine based lipidated biphenyls as agents with anti-biofilm and anti-inflammatory properties that also inhibit intracellular bacteria

Chem. Commun., 2017,53, 8427-8430, DOI: 10.1039/C7CC04206J

 

A review on cell wall synthesis inhibitors with an emphasis on glycopeptide antibiotics

Med. Chem. Commun., 2017,8, 516-533, DOI: 10.1039/C6MD00585C

 

Aryl-alkyl-lysines: small molecular membrane-active antiplasmodial agents

Med. Chem. Commun., 2017,8, 434-439, DOI: 10.1039/C6MD00589F

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Introducing new MedChemComm Editor-in-Chief, Professor Gerhard Ecker

MedChemComm Editor-in-Chief Gerhard Ecker

MedChemComm is very excited to welcome to the team our new Editor-in-Chief, Professor Gerhard Ecker. Prof. Ecker is the current head of the Pharmacoinformatics Research Group in the Department of Medicinal Chemistry at the University of Vienna. His research interests include ligand- and structure-based drug design, focusing on transmembrane transport proteins and the prediction of on- and off-kinetics, as well as semantic data integration.

He completed his PhD at the University of Vienna under the supervision of Professor Fleischhacker and Professor Noe before taking a post-doctoral position with Professor Seydel’s group in Borstel, Germany.

Gerhard has previously held positions as President of the European Federation for Medicinal Chemistry and vice-president of the Austrian Pharmaceutical Society.

 

He has published over 100 full papers, including:

Probing the stereoselectivity of P-glycoprotein-synthesis, biological activity and ligand docking studies of a set of enantiopure benzopyrano[3,4-b][1,4]oxazines
Chem. Commun., 2011, 47, 2586-2588

Open PHACTS computational protocols for in silico target validation of cellular phenotypic screens: knowing the knowns
Med. Chem. Commun., 2016, 7, 1237-1244

From linked open data to molecular interaction: studying selectivity trends for ligands of the human serotonin and dopamine transporter
Med. Chem. Commun., 2016, 7, 1819-1831

 

For more information, visit his lab group website.

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