Recent HOT MedChemComm articles

The following MedChemComm articles have all been recommened by the reviewers of the articles as being particularly interesting or particularly significant research. These have all been made free to access until 12th December 2014. The order they appear in the list holds no special meaning or ranking.

Imidazole derivatives show anticancer potential by inducing apoptosis and cellular senescence
Gangavaram V. M. Sharma, Adepu Ramesh, Ashita Singh, Gourishetty Srikanth, Vankudoth Jayaram, Divya Duscharla, Jung Ho Jun, Ramesh Ummanni and Sanjay V. Malhotra  
DOI: 10.1039/C4MD00277F, Concise Article

C4MD00277F


Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor
Katherine S. England, Anthony Tumber, Tobias Krojer, Giuseppe Scozzafava, Stanley S. Ng, Michelle Daniel, Aleksandra Szykowska, KaHing Che, Frank von Delft, Nicola A. Burgess-Brown, Akane Kawamura, Christopher J. Schofield and Paul E. Brennan  
DOI: 10.1039/C4MD00291A, Concise Article
From themed collection Epigenetics

C4MD00291A GA


Computationally motivated synthesis and enzyme kinetic evaluation of N-(β-D-glucopyranosyl)-1,2,4-triazolecarboxamides as glycogen phosphorylase inhibitors
Jaida Begum, Gergely Varga, Tibor Docsa, Pál Gergely, Joseph M. Hayes, László Juhász and László Somsák  
DOI: 10.1039/C4MD00335G, Concise Article

C4MD00335G GA


Synthesis and biological evaluation of a series of aryl triazoles as firefly luciferase inhibitors
Haixiu Bai, Peng Zhu, Wenxiao Wu, Jing Li, Zhao Ma, Wei Zhang, Yanna Cheng, Lupei Du and Minyong Li  
DOI: 10.1039/C4MD00368C, Concise Article

C4MD00368C GA


Rational design of protein–protein interaction inhibitors
Didier Rognan  
DOI: 10.1039/C4MD00328D, Review Article

C4MD00328D GA

 

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