MedChemComm issue 12: featuring macrocyclization efficiency & transdermal insulin delivery

Welcome to issue 12 of MedChemComm, the last of 2012. This month we have 10 concise articles and 1 review for you to devour.

On the front cover:

Is this review from our collection on ‘The space in-between small molecules and biologicals’ by James C. Collins and Keith James. Collins and James present a critical analysis of macrocyclization reactions published over the past three years, and based on this propose a ‘macrocyclization efficiency index, Emac,’ which would allow the community to determine the true efficiency of a macrocyclization reaction.

Emac – a comparative index for the assessment of macrocyclization efficiency
James C. Collins and Keith James
DOI: 10.1039/C2MD20176C

On the inside cover:

Is this concise article from Masahiro Goto and colleagues who present their investigations into developing a unique, through the skin, protein-delivery system based on a solid-in-oil nanodispersion that utilizes an oil-based vehicle of proteins.

Transdermal delivery of insulin using a solid-in-oil nanodispersion enhanced by arginine-rich peptides
Yoshiro Tahara, Shota Honda, Noriho Kamiya and Masahiro Goto
DOI: 10.1039/C2MD20059G

Remember both of these articles are free to access for the next 6 weeks!

Get your hands on the last issue of 2012 today.

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