Take a look at the top 5 most downloaded MedChemComm articles in 2012 and blog your thoughts and comments below.
The developability of heteroaromatic and heteroaliphatic rings – do some have a better pedigree as potential drug molecules than others?
Timothy J. Ritchie, Simon J. F. Macdonald, Simon Peace, Stephen D. Pickett and Christopher N. Luscombe
Med. Chem. Commun., 2012,3, 1062-1069, DOI: 10.1039/C2MD20111A
Gd(III) chelates for MRI contrast agents: from high relaxivity to “smart”, from blood pool to blood–brain barrier permeable
Chang-Tong Yang and Kai-Hsiang Chuang
Med. Chem. Commun., 2012,3, 552-565, DOI: 10.1039/C2MD00279E
The use of phosphate bioisosteres in medicinal chemistry and chemical biology
Thomas S. Elliott, Aine Slowey, Yulin Ye and Stuart J. Conway
Med. Chem. Commun., 2012,3, 735-751, DOI: 10.1039/C2MD20079A
Inhibition of bromodomain-mediated protein–protein interactions as a novel therapeutic strategy
Silviya D. Furdas, Luca Carlino, Wolfgang Sippl and Manfred Jung
Med. Chem. Commun., 2012,3, 123-134, DOI: 10.1039/C1MD00201E
Development of second generation epigenetic agents
Med. Chem. Commun., 2012,3, 135-161, DOI: 10.1039/C1MD00199J