Albert A. Bowers, Purdue University, provides a review focussing on emerging biochemical and biosynthetic methods for the development of peptidomimetic libraries, in particular constrained cyclic peptide libraries that contain natural product-like features, with an emphasis given to small molecules of 30 residues or less.
- Non-ribosomal peptide synthetases (NRPS) or hybrid polyketide (NRPS/PKS) derived libraries
- Ribosomal peptide libraries
- Non-natural product-based technologies for library preparation
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This review is part of MedChemComm’s soon to be published Natural Products themed issue, guest-edited by Prof. Christopher Walsh and Dr Sylvie Garneau-Tsodikova.