RSC Medicinal Chemistry Blog

Albert A. Bowers, Purdue University, provides a review focussing on emerging biochemical and biosynthetic methods for the development of peptidomimetic libraries, in particular constrained cyclic peptide libraries that contain natural product-like features, with an emphasis given to small molecules of 30 residues or less.

Discussion includes:

• Non-ribosomal peptide synthetases (NRPS) or hybrid polyketide (NRPS/PKS) derived libraries
• Ribosomal peptide libraries
• Non-natural product-based technologies for library preparation

Want to know more? Have a look now and let us know your thoughts…

Biochemical and biosynthetic preparation of natural product-like cyclic peptide libraries
Albert A. Bowers
DOI: 10.1039/C2MD20068F

This review is part of MedChemComm’s soon to be published Natural Products themed issue, guest-edited by Prof. Christopher Walsh and Dr Sylvie Garneau-Tsodikova.