Top ten most accessed articles in March

This month sees the following articles in MedChemComm that are in the top ten most accessed:-

Molecular obesity, potency and other addictions in drug discovery 
Michael M. Hann 
Med. Chem. Commun., 2011, Advance Article DOI: 10.1039/C1MD00017A, Review 

Synthesis and SAR studies of benzimidazole derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists: Focus to detune hERG inhibition 
Pradip K. Sasmal, Sanjita Sasmal, Chandrasekhar Abbineni, B. Venkatesham, P. Tirumala Rao, M. Roshaiah, Ish Khanna, V. J. Sebastian, J. Suresh, Manvendra P. Singh, Rashmi Talwar, Dhanya Shashikumar, K. Harinder Reddy, Thomas M. Frimurer, Øystein Rist, Lisbeth Elster and Thomas Högberg 
Med. Chem. Commun., 2011, Advance Article DOI: 10.1039/C1MD00015B, Concise Article 

Novel indolizine compounds as potent inhibitors of phosphodiesterase IV (PDE4): structure-activity relationship 
Shoujun Chen, Zhiqiang Xia, Masazumi Nagai, Rongzhen Lu, Elena Kostik, Teresa Przewloka, Minghu Song, Dinesh Chimmanamada, David James, Shijie Zhang, Jun Jiang, Mitsunori Ono, Keizo Koya and Lijun Sun 
Med. Chem. Commun., 2011, 2, 176-180 DOI: 10.1039/C0MD00215A, Concise Article 

The discovery of a novel prototype small molecule TLR7 agonist for the treatment of hepatitis C virus infection 
David C. Pryde, Thien-Duc Tran, Peter Jones, Gemma C. Parsons, Gerwyn Bish, Fiona M. Adam, Mya C. Smith, Donald S. Middleton, Nick N. Smith, Frederick Calo, Duncan Hay, Michael Paradowski, Katie J. W. Proctor, Tanya Parkinson, Carl Laxton, David N. A. Fox, Nigel J. Horscroft, Giuseppe Ciaramella, Hannah M. Jones, Jonathan Duckworth, Neil Benson, Anthony Harrison and Rob Webster 
Med. Chem. Commun., 2011, 2, 185-189 DOI: 10.1039/C0MD00197J, Concise Article 

Discovery and pharmacological characterization of a selective delta opiate receptor antagonist (CP-646,777) 
Spiros Liras, Stanton F. McHardy, Martin P. Allen, Barb E. Segelstein, Steven D. Heck, Dianne K. Bryce, Anne W. Schmidt, Rebecca O’Connor, Michelle Vanase-Frawley, Ernesto Callegari and Stafford McLean 
Med. Chem. Commun., 2011, Advance Article DOI: 10.1039/C0MD00249F, Concise Article 

The importance of solvation in the design of ligands targeting membrane proteins 
Angel González, Marta Murcia, Bellinda Benhamú, Mercedes Campillo, María L. López-Rodríguez and Leonardo Pardo 
Med. Chem. Commun., 2011, 2, 160-164 DOI: 10.1039/C0MD00258E, Concise Article 

The p53-MDM2/MDMX axis – A chemotype perspective 
Kareem Khoury, Grzegorz M. Popowicz, Tad A. Holak and Alexander Dömling 
Med. Chem. Commun., 2011, 2, 246-260 DOI: 10.1039/C0MD00248H, Review 

Chemical space as a source for new drugs 
Jean-Louis Reymond, Ruud van Deursen, Lorenz C. Blum and Lars Ruddigkeit 
Med. Chem. Commun., 2010, 1, 30-38 DOI: 10.1039/C0MD00020E, Review 

Tacrine-mefenamic acid hybrids for inhibition of acetylcholinesterase 
Joshua J. Bornstein, Todd J. Eckroat, Jacob L. Houghton, Christopher K. Jones, Keith D. Green and Sylvie Garneau-Tsodikova 
Med. Chem. Commun., 2011, Advance Article DOI: 10.1039/C0MD00256A, Concise Article 

Synthesis, in silico screening and bioevaluation of dispiro-cycloalkanones as antitubercular and mycobacterial NAD+-dependent DNA ligase inhibitors 
Rama P. Tripathi, Jyoti Pandey, Vandana Kukshal, Arya Ajay, Mridul Mishra, Divya Dube, Deepti Chopra, R. Dwivedi, Vinita Chaturvedi and Ravishankar Ramachandran 
Med. Chem. Commun., 2011, Advance Article DOI: 10.1039/C0MD00246A, Concise Article 

Why not take a look at the articles today and blog your thoughts and comments below.

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