Introducing MedChemComm Associate Editor Sally-Ann Poulsen

Professor Sally-Ann Poulsen

 

We are delighted to welcome to the team Professor Sally-Ann Poulsen, new MedChemComm Associate Editor.

 

Professor Poulsen’s research focuses on the development of new chemical probes, medicinal chemistry targeting cancer and infectious disease, and on fragment screening using native state mass spectrometry. You can find out more on her webpage.

 

Sally-Ann received her PhD in Medicinal Chemistry from Griffith University, before undertaking a Royal Society & National Health and Medical Research Council (NHMRC) Howard Florey Research Fellowship at the University of Cambridge. On returning to Australia, she was awarded an Australian Research Council QEII Fellowship, followed by an Australian Research Council Future Fellowship, and is now Professor of Chemical Biology and acting Deputy Director at Griffith Institute for Drug Discovery (GRIDD), Griffith University, Brisbane, Australia.

 

Professor Poulsen is also a Fellow of the Royal Australian Chemical Institute (RACI) (2017), Chair elect of the RACI Medicinal Chemistry and Chemical Biology Division and is a global council member of the International Chemical Biology Society.

 

Upon joining the MedChemComm team, Poulsen commented,

“I value research integrity and am truly excited to have an opportunity to help MedChemComm to share the wonderful science that is generated by the global medicinal chemistry community.”

 

Submit your research to Sally-Ann now!

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Medicinal Chemistry Residential School 2019

The Royal Society of Chemistry Medicinal Chemistry Residential School is designed for graduate and post-doctoral chemists and will take place at Loughborough University from 2-7 June 2019.

Register now!

The meeting will cover topics of interest to drug discovery researchers, helping to increase understanding of the factors governing modern drug discovery from the initial concept through to translational science and intellectual property. Established since 1981, our Residential School has trained many of the world’s leading medicinal chemists working in the pharmaceutical industry and academic research institutes.


Examples of feedback from previous Residential School Delegates:

“It was an extremely worthwhile experience that greatly clarified a haze of vague knowledge, as well as taught me things I’ve never thought about before.”

“Great range of topics with a good balance of lectures and tutorials. I really enjoyed the week and definitely feel that I have learnt a lot. Would recommend to everyone.”

If you are interested in the event find out more information and register here.

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Outstanding Reviewers for MedChemComm in 2018

We would like to highlight the Outstanding Reviewers for MedChemComm in 2018, as selected by the editorial team, for their significant contribution to the journal. The reviewers have been chosen based on the number, timeliness and quality of the reports completed over the last 12 months.

We would like to say a big thank you to those individuals listed here as well as to all of the reviewers that have supported the journal. Each Outstanding Reviewer will receive a certificate to give recognition for their significant contribution.

Dr Thomas Alanine, Sygnature Discovery (http://orcid.org/0000-0002-3349-0726)
Professor Kelly Chibale, University of Cape Town (http://orcid.org/0000-0003-0731-5286)
Dr Vijay Chudasama, University College London (http://orcid.org/0000-0002-8876-3285)
Dr Brenda Farrell, Baylor College of Medicine (http://orcid.org/0000-0003-0847-6401)
Dr Micha Fridman, Tel Aviv University
Dr Keith Green, University of Kentucky
Dr Jared Hammill, University of Kentucky
Dr Katarzyna Kononowicz, Uniwersytet Jagiellonski w Krakowie Collegium Medicum (http://orcid.org/0000-0002-6752-7443)
Dr Alex Poot, Amsterdam University Medical Center (http://orcid.org/0000-0002-7466-4171)
Dr Brad Sleebs, Walter and Eliza Hall Institute of Medical Research (http://orcid.org/0000-0001-9117-1048)

We would also like to thank the MedChemComm board and the medicinal chemistry community for their continued support of the journal, as authors, reviewers and readers.

If you would like to become a reviewer for our journal, just email us at medchemcomm@rsc.org with details of your research interests and an up-to-date CV or résumé. You can find more details in our author and reviewer resource centre

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2019 MedChemComm Emerging Investigator Lectureship Winner

Congratulations to Professor Amanda Hargrove from Duke University, USA, the recipient of the 2019 MedChemComm Emerging Investigator Lectureship!

The Lectureship was open to any candidate who received their PhD in 2009 or later and have made a significant contribution to medicinal chemistry in their early career. The MedChemComm Editorial Board then voted on a short-list of nominations.

Many congratulations to Prof. Hargrove for winning the lectureship.

About Amanda

Amanda E. Hargrove, Ph.D. joined the faculty at Duke University in 2013 as an Assistant Professor of Chemistry following an NIH postdoctoral fellowship with Professor Peter B. Dervan at the California Institute of Technology and doctoral research at the University of Texas at Austin with Professors Eric V. Anslyn and Jonathan L. Sessler. Her research group at Duke focuses on developing small molecule probes to investigate the structure and function of RNA molecules relevant to human disease. You can find out more about their research by visiting the laboratory webpage.

Prof. Hargrove holds a secondary appointment in the Biochemistry Department and membership in the Duke Cancer Institute, Duke Cellular and Molecular Biology Program, and the Center for Biological and Tissue Engineering. Her recent honors include the ChemComm Emerging Investigator Lectureship, NSF CAREER Award, Cottrell Scholar Award, and the Prostate Cancer Young Investigator Award.

For a selection of her excellent research, please see some of Prof. Hargrove’s recent works below.

 

Fluorescent peptide displacement as a general assay for screening small molecule libraries against RNA

Org. Biomol. Chem., 2019, 17, 1778-1786

Part of the themed collection: New Talent

 

Sensing the impact of environment on small molecule differentiation of RNA sequences

Chem. Commun., 2017, 53, 13363-13366

Part of the themed collection: Chemosensors and Molecular Logic

 

Amiloride as a new RNA-binding scaffold with activity against HIV-1 TAR

Med. Chem. Commun., 2017,8, 1022-1036

Part of the themed collection: 2017 Hot Articles in MedChemComm

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2019 MedChemComm Emerging Investigator Lectureship – nominations open

The 2019 MedChemComm Emerging Investigator Lectureship is now open for nominations.

Nominations will close 22 November 2018.

The recipient of the lectureship will receive a contribution of up to £1000 towards speaking at a conference in 2019.

Qualification
The lectureship is open to candidates who received their PhD in 2009 or later and who have made a significant contribution to medicinal chemistry in their early career, particularly if they have brought new ideas to drug discovery.

How you can nominate
If you would like to nominate someone please email us (medchemcomm-rsc@rsc.org) with the following details:

  • Their name
  • Their affiliation
  • At least one paragraph explaining their achievements and why you think they should be considered

Additional supporting information, for example their CV, is very helpful in making a decision but is not mandatory for making a nomination.

Self-nominations are accepted but must be supported by a letter of support from your Head of Departments or similar person at your institute.

Selection
All qualified nominations will be considered and a short-list of candidates with be selected based on the information provided at nomination. The MedChemComm Editorial Board will then vote to select the recipient and the winner will be announced in late 2018.

Previous lectureship winners include:

  • Dr. Gonçalo Bernardes (University of Cambridge, UK) – 2018
  • Dr Laura H. Heitman (Leiden University, Netherlands) – 2017
  • Dr Alessio Ciulli (University of Dundee, UK) – 2016
  • Professor Richard Payne (University of Sydney, Australia) – 2015
  • Professor Christian Heinis (École Polytechnique Fédérale de Lausanne, Switzerland) – 2013
  • Professor Patrick Gunning (University of Toronto, Canada) – 2012
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MedChemComm welcomes Professor Jayanta Haldar to the Editorial Board

We are delighted to welcome to the team Professor Jayanta Haldar of the Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bangalore, India.

Jayanta studied at Presidency College, University of Calcutta before moving to the Indian Institute of Science, Bangalore for an M.Sc. and Ph.D.. In 2004, he took up a postdoctoral position at the Massachusetts Institute of Technology, USA with Alexander Klibanov. Subsequently, Jayanta returned to India to take up an Assistant Professor position at JNCASR, his current faculty, where he was made Associate Professor in 2015.

Professor Haldar’s group specializes in the development of novel antimicrobial therapeutics, coatings and surfaces, alongside novel nano-delivery systems for drugs. To find out more about his research, take a look at the group webpage, or read a few of his many publications:

 

Selectively targeting bacteria by tuning the molecular design of membrane-active peptidomimetic amphiphiles

Chem. Commun., 2018,54, 4943-4946, DOI: 10.1039/C8CC01926F

 

L-Lysine based lipidated biphenyls as agents with anti-biofilm and anti-inflammatory properties that also inhibit intracellular bacteria

Chem. Commun., 2017,53, 8427-8430, DOI: 10.1039/C7CC04206J

 

A review on cell wall synthesis inhibitors with an emphasis on glycopeptide antibiotics

Med. Chem. Commun., 2017,8, 516-533, DOI: 10.1039/C6MD00585C

 

Aryl-alkyl-lysines: small molecular membrane-active antiplasmodial agents

Med. Chem. Commun., 2017,8, 434-439, DOI: 10.1039/C6MD00589F

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Introducing new MedChemComm Editor-in-Chief, Professor Gerhard Ecker

MedChemComm Editor-in-Chief Gerhard Ecker

MedChemComm is very excited to welcome to the team our new Editor-in-Chief, Professor Gerhard Ecker. Prof. Ecker is the current head of the Pharmacoinformatics Research Group in the Department of Medicinal Chemistry at the University of Vienna. His research interests include ligand- and structure-based drug design, focusing on transmembrane transport proteins and the prediction of on- and off-kinetics, as well as semantic data integration.

He completed his PhD at the University of Vienna under the supervision of Professor Fleischhacker and Professor Noe before taking a post-doctoral position with Professor Seydel’s group in Borstel, Germany.

Gerhard has previously held positions as President of the European Federation for Medicinal Chemistry and vice-president of the Austrian Pharmaceutical Society.

 

He has published over 100 full papers, including:

Probing the stereoselectivity of P-glycoprotein-synthesis, biological activity and ligand docking studies of a set of enantiopure benzopyrano[3,4-b][1,4]oxazines
Chem. Commun., 2011, 47, 2586-2588

Open PHACTS computational protocols for in silico target validation of cellular phenotypic screens: knowing the knowns
Med. Chem. Commun., 2016, 7, 1237-1244

From linked open data to molecular interaction: studying selectivity trends for ligands of the human serotonin and dopamine transporter
Med. Chem. Commun., 2016, 7, 1819-1831

 

For more information, visit his lab group website.

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Outstanding Reviewers for MedChemComm in 2017

Outstanding Reviewers for MedChemComm in 2017

We would like to highlight the Outstanding Reviewers for MedChemComm in 2017, as selected by the editorial team, for their significant contribution to the journal. The reviewers have been chosen based on the number, timeliness and quality of the reports completed over the last 12 months.

We would like to say a big thank you to those individuals listed here as well as to all of the reviewers that have supported the journal. Each Outstanding Reviewer will receive a certificate to give recognition for their significant contribution.

Dr Andreas Brunschweiger, TU Dortmund, Germany, ORCID: 0000-0002-4401-1495 
Dr David Colby, University of Mississippi, USA, ORCID: 0000-0002-5434-1690
Professor Paul Furtmüller, BOKU-University of Natural Resources and Life Sciences, Austria, ORCID: 0000-0002-1199-2469
Dr Keith Green, University of Kentucky, USA
Dr Ke Jiang, Stanford University, USA
Dr Mukulesh Mondal, Oakland University, USA
Dr Concepcion Sanchez-Martinez, Lilly, Spain, ORCID: 0000-0003-0221-497X
Professor Mike Waring, Newcastle University, UK, ORCID: 0000-0002-9110-8783
Dr Zhiqiang Yu, Southern Medical University, China
Dr Ye Zhang, Guangxi Normal University, China, ORCID: 0000-0002-6903-5602

We would also like to thank the MedChemComm board and the wider community for their continued support of the journal, as authors, reviewers and readers.

If you would like to become a reviewer for our journal you can find more details in our author and reviewer resource centre

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Dr. Gonçalo Bernardes wins the 2018 Emerging Investigator Lectureship

We are delighted to announce that Dr. Gonçalo Bernardes has been selected to receive the 2018 MedChemComm Emerging Investigator Lectureship

The lectureship was open to any candidate who received their PhD in 2008 or later and have made a significant contribution to medicinal chemistry in their early career. The Editorial Board feel that his substantial contributions to the chemistry of protein conjugates, and his impact on the field of antibody conjugates make him an excellent choice for this year’s lectureship.

On being informed of his selection Dr. Bernardes said:

I am honoured to receive this distinction from an organisation I admire so much and so incredibly proud of the work of my entire research group at Cambridge and iMM Lisbon.”

Dr. Bernardes will give his lecture later this year at a conference to be confirmed.

About Dr. Gonçalo Bernardes

Dr. Gonçalo Bernardes is a Group Leader at the Department of Chemistry, University of Cambridge, U.K.. He is also the Director of the Chemical Biology and Pharmaceutical Biotechnology Unit at the Instituto de Medicina Molecular, Portugal. After completing his D.Phil. degree in 2008 at the University of Oxford, U.K., he undertook postdoctoral work at the Max-Planck Institute of Colloids and Interfaces, Germany, and the ETH Zürich, Switzerland, and worked as a Group Leader at Alfama Lda in Portugal. He started his independent research career in 2013, and his research group tackles a range of biological problems of fundamental importance to understand and fight human disease primarily through the use of chemistry principles. He is a Royal Society University Research Fellow and the awardee of a Starting Grant from the European Research Council (TagIt).

Visit Gonçalo’s homepage to find out more about his ongoing research.

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What are your colleagues reading in MedChemComm?

The articles below are some of the most read MedChemComm articles in April, May and June 2017.

Review Articles:

Multivalent glycoconjugates as vaccines and potential drug candidates
Sumati Bhatia, Mathias Dimde and Rainer Haag
DOI: 10.1039/C4MD00143E

Surface plasmon resonance for the characterization of bacterial polysaccharide antigens: a review
Barbara Brogioni and Francesco Berti
DOI: 10.1039/C4MD00088A

Recent advances in the rational design and optimization of antibacterial agents
Jesse A. Jones, Kristopher G. Virga, Giuseppe Gumina and Kirk E. Hevener
DOI: 10.1039/C6MD00232C

Polypharmacology modelling using proteochemometrics (PCM): recent methodological developments, applications to target families, and future prospects
Isidro Cortés-Ciriano, Qurrat Ul Ain, Vigneshwari Subramanian, Eelke B. Lenselink, Oscar Méndez-Lucio, Adriaan P. IJzerman, Gerd Wohlfahrt, Peteris Prusis, Thérèse E. Malliavin, Gerard J. P. van Westen and Andreas Bender
DOI: 10.1039/C4MD00216D

Protein–ligand (un)binding kinetics as a new paradigm for drug discovery at the crossroad between experiments and modelling
M. Bernetti, A. Cavalli and L. Mollica
DOI: 10.1039/C6MD00581K

Structural biology and chemistry of protein arginine methyltransferases
Matthieu Schapira and Renato Ferreira de Freitas
DOI: 10.1039/C4MD00269E

Small molecule-mediated protein knockdown as a new approach to drug discovery
Christopher P. Tinworth, Hannah Lithgow and Ian Churcher
DOI: 10.1039/C6MD00347H

Chemical probes and inhibitors of bromodomains outside the BET family
Moses Moustakim, Peter G. K. Clark, Duncan A. Hay, Darren J. Dixon and Paul E. Brennan
DOI: 10.1039/C6MD00373G

Amphiphilic designer nano-carriers for controlled release: from drug delivery to diagnostics
Malinda Salim, Hiroyuki Minamikawa, Akihiko Sugimura and Rauzah Hashim
DOI: 10.1039/C4MD00085D

2-[18F]Fluoroethyl tosylate – a versatile tool for building 18F-based radiotracers for positron emission tomography
Torsten Kniess, Markus Laube, Peter Brust and Jörg Steinbach
DOI: 10.1039/C5MD00303B

Structural features of many circular and leaderless bacteriocins are similar to those in saposins and saposin-like peptides
K. M. Towle and J. C. Vederas
DOI: 10.1039/C6MD00607H

Bacterial lipid membranes as promising targets to fight antimicrobial resistance, molecular foundations and illustration through the renewal of aminoglycoside antibiotics and emergence of amphiphilic aminoglycosides
Marie-Paule Mingeot-Leclercq and Jean-Luc Décout
DOI: 10.1039/C5MD00503E

Research Articles:

Towards understanding cell penetration by stapled peptides
Qian Chu, Raymond E. Moellering, Gerard J. Hilinski, Young-Woo Kim, Tom N. Grossmann, Johannes T.-H. Yeh and Gregory L. Verdine
DOI: 10.1039/C4MD00131A

Design and synthesis of DNA-encoded libraries based on a benzodiazepine and a pyrazolopyrimidine scaffold
M. Klika Škopić, O. Bugain, K. Jung, S. Onstein, S. Brandherm, T. Kalliokoski and A. Brunschweiger
DOI: 10.1039/C6MD00243A

Methods of protein surface PEGylation under structure preservation for the emulsion-based formation of stable nanoparticles
Lydia Radi, Matthias Fach, Mirko Montigny, Elena Berger-Nicoletti, Wolfgang Tremel and Peter R. Wich
DOI: 10.1039/C5MD00475F

Identification of imidazo[1,2-b]pyridazine TYK2 pseudokinase ligands as potent and selective allosteric inhibitors of TYK2 signalling
R. Moslin, D. Gardner, J. Santella, Y. Zhang, J. V. Duncia, C. Liu, J. Lin, J. S. Tokarski, J. Strnad, D. Pedicord, J. Chen, Y. Blat, A. Zupa-Fernandez, L. Cheng, H. Sun, C. Chaudhry, C. Huang, C. D’Arienzo, J. S. Sack, J. K. Muckelbauer, C. Chang, J. Tredup, D. Xie, N. Aranibar, J. R. Burke, P. H. Carter and D. S. Weinstein
DOI: 10.1039/C6MD00560H

Exploring the links between peptoid antibacterial activity and toxicity
H. L. Bolt, G. A. Eggimann, C. A. B. Jahoda, R. N. Zuckermann, G. J. Sharples and S. L. Cobb
DOI: 10.1039/C6MD00648E

Nonomuraea sp. ATCC 55076 harbours the largest actinomycete chromosome to date and the kistamicin biosynthetic gene cluster
Behnam Nazari, Clarissa C. Forneris, Marcus I. Gibson, Kyuho Moon, Kelsey R. Schramma and Mohammad R. Seyedsayamdost
DOI: 10.1039/C6MD00637J

Structure-based virtual screening for fragment-like ligands of the G protein-coupled histamine H4 receptor
Enade P. Istyastono, Albert J. Kooistra, Henry F. Vischer, Martien Kuijer, Luc Roumen, Saskia Nijmeijer, Rogier A. Smits, Iwan J. P. de Esch, Rob Leurs and Chris de Graaf
DOI: 10.1039/C5MD00022J

Human lysosomal acid lipase inhibitor lalistat impairs Mycobacterium tuberculosis growth by targeting bacterial hydrolases
J. Lehmann, J. Vomacka, K. Esser, M. Nodwell, K. Kolbe, P. Rämer, U. Protzer, N. Reiling and S. A. Sieber
DOI: 10.1039/C6MD00231E

Design and synthesis of potent and selective inhibitors of BRD7 and BRD9 bromodomains
Duncan A. Hay, Catherine M. Rogers, Oleg Fedorov, Cynthia Tallant, Sarah Martin, Octovia P. Monteiro, Susanne Müller, Stefan Knapp, Christopher J. Schofield and Paul E. Brennan
DOI: 10.1039/C5MD00152H

A fundamental view of enthalpy–entropy compensation
Ulf Ryde
DOI: 10.1039/C4MD00057A

Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor
Katherine S. England, Anthony Tumber, Tobias Krojer, Giuseppe Scozzafava, Stanley S. Ng, Michelle Daniel, Aleksandra Szykowska, KaHing Che, Frank von Delft, Nicola A. Burgess-Brown, Akane Kawamura, Christopher J. Schofield and Paul E. Brennan
DOI: 10.1039/C4MD00291A

From linked open data to molecular interaction: studying selectivity trends for ligands of the human serotonin and dopamine transporter
Barbara Zdrazil, Eva Hellsberg, Michael Viereck and Gerhard F. Ecker
DOI: 10.1039/C6MD00207B

Keep up-to-date with the latest issues of MedChemComm with our E-alerts

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