Coinciding with the 70th anniversary of the discovery of streptomycin, Issue 5 puts the focus on chemical biology research in Asia, beginning with an editorial from guest editors Minoru Yoshida, Seung Bum Park and Charles Boone. This issue contains 24 top articles from chemical biologists working in Asia.
Focus on chemical biology in Asia
Minoru Yoshida, Seung Bum Park and Charles Boone
The outside front cover highlights work from Pohang University of Science and Technology on overcoming the difficulties in delivering oligonucleotides to specific tissues using estrone-conjugated siRNAs.
Tissue specific delivery of estrone-conjugated siRNAs
Eun-Kyoung Bang, Eun Mi Jeon, Wanil Kim, Kyung-Ha Lee, Kyong-Tai Kim and Byeang Hyean Kim
A communication from Junko Ohkanda et al. at Osaka University is featured on the inside front cover. The researchers improve the efficiency of protein-protein interaction inhibitors by 200% using 14-3-3 peptides. This article was the subject of a blog post in January, read it here for further explanation.
Chemical ligation of epoxide-containing fusicoccins and peptide fragments guided by 14-3-3 protein
Toshio Maki, Akie Kawamura, Nobuo Kato and Junko Ohkanda
There are several intriguing review articles in Issue 5, including three HOT reviews:
Chemical biology-based approaches on fluorescent labeling of proteins in live cells
Deokho Jung, Kyoungmi Min, Juyeon Jung, Wonhee Jang and Youngeun Kwon
Small-molecular modulators of cancer-associated epigenetic mechanisms
Yukihiro Itoh, Takayoshi Suzuki and Naoki Miyata
Synthetic cysteine surrogates used in native chemical ligation
Clarence T. T. Wong, Chun Ling Tung and Xuechen Li
Plus plenty more HOT primary research articles:
Dual-labeled glycoclusters: synthesis and their application in monitoring lectin-mediated endocytosis
Xizhe Tian, Kyung-Hwa Baek and Injae Shin
Innate immunomodulation by lipophilic termini of lipopolysaccharide; synthesis of lipid As from Porphyromonas gingivalis and other bacteria and their immunomodulative responses
Yukari Fujimoto, Atsushi Shimoyama, Akinori Saeki, Naohiro Kitayama, Chika Kasamatsu, Hiroko Tsutsui and Koichi Fukase