Lyn received his undergraduate education at the University of Bath and then completed PhD studies with Prof. Alan Armstrong at the University of Nottingham in synthetic organic chemistry. He then started his post doctorate research with Prof. Kim Janda at The Scripps Research Institute, California in the area of chemical biology. In 2001, he joined Pfizer in Sandwich, UK as a medicinal chemistry team leader and his contributions to the early clinical portfolio were recognised with the inaugural Royal Society of Chemistry Young Industrialist of the Year Award in 2009.
He recently transferred to Cambridge, Massachusetts to lead the Chemical Biology and Rare Diseases Chemistry groups in Pfizer. His research interests include the development of novel chemoproteomic technologies that report on target engagement in intact cells, and the use of medicinal chemistry to advance biotherapeutic modalities. He is a Fellow of the Royal Society of Chemistry (FRSC) and the Society of Biology (FSB), and is an elected member of the Chemistry-Biology Interface Division of the RSC. Recently, he was also a Guest Editor for a themed issue on Chemical Biology for Target Identification and Validation in our sister MedChemComm.
|“It’s an honour to join the board of this prestigious journal, which has become essential reading for those working at the interface of chemistry and biology. In particular, I’m very keen to see the inevitable growth in the application of chemical biology research within the drug discovery setting, and MBS is ideally poised to share these advances with a wide audience.” - Lyn Jones
Some of Lyn’s recent publications include:
Aryloxymaleimides for cysteine modification, disulfide bridging and the dual functionalization of disulfide bonds
Chem. Commun., DOI: 10.1039/C4CC02107J, Communication
Understanding and applying tyrosine biochemical diversity
Mol. BioSyst., DOI: 10.1039/C4MB00018H, Review Article
Target validation using in-cell small molecule clickable imaging probes
Med. Chem. Commun., DOI: 10.1039/C3MD00277B, Review Article
Chemical motifs that redox cycle and their associated toxicity
Med. Chem. Commun., DOI: 10.1039/C3MD00149K, Concise Article
Recent Developments using Chemical and Molecular Biology
Lyn H Jones (Editor), Andrew J McKnight (Editor)
ISBN (print): 978-1-84973-601-5