Archive for the ‘Top Ten’ Category

What are your colleagues reading in Molecular BioSystems?

The articles below are some of the most read Molecular BioSystems articles in April, May and June 2016.

Isothermal amplified detection of DNA and RNA
Lei Yan, Jie Zhou, Yue Zheng, Adam S. Gamson, Benjamin T. Roembke, Shizuka Nakayama and Herman O. Sintim
DOI: 10.1039/C3MB70304E

Proteomic analysis of exosomal cargo: the challenge of high purity vesicle isolation
Agata Abramowicz, Piotr Widlak and Monika Pietrowska
DOI: 10.1039/C6MB00082G

Why phosphoproteomics is still a challenge
Fiorella A. Solari, Margherita Dell’Aica, Albert Sickmann and René P. Zahedi
DOI: 10.1039/C5MB00024F

Peptide-tags for site-specific protein labelling in vitro and in vivo
Jonathan Lotze, Ulrike Reinhardt, Oliver Seitz and Annette G. Beck-Sickinger
DOI: 10.1039/C6MB00023A

Trials and tribulations of ‘omics data analysis: assessing quality of SIMCA-based multivariate models using examples from pulmonary medicine
Åsa M. Wheelock and Craig E. Wheelock
DOI: 10.1039/C3MB70194H

Mechanism of action-based classification of antibiotics using high-content bacterial image analysis
Kelly C. Peach, Walter M. Bray, Dustin Winslow, Peter F. Linington and Roger G. Linington
DOI: 10.1039/C3MB70027E

Bridging the layers: towards integration of signal transduction, regulation and metabolism into mathematical models
Emanuel Gonçalves, Joachim Bucher, Anke Ryll, Jens Niklas, Klaus Mauch, Steffen Klamt, Miguel Rocha and Julio Saez-Rodriguez
DOI: 10.1039/C3MB25489E

Elucidating the interaction of limonene with bovine serum albumin: a multi-technique approach
Sumit Kumar Chaturvedi, Ejaz Ahmad, Javed Masood Khan, Parvez Alam, Mohd Ishtikhar and Rizwan Hasan Khan
DOI: 10.1039/C4MB00548A

PLS/OPLS models in metabolomics: the impact of permutation of dataset rows on the K-fold cross-validation quality parameters
Mohamed N. Triba, Laurence Le Moyec, Roland Amathieu, Corentine Goossens, Nadia Bouchemal, Pierre Nahon, Douglas N. Rutledge and Philippe Savarin
DOI: 10.1039/C4MB00414K

The transcriptome of Euglena gracilis reveals unexpected metabolic capabilities for carbohydrate and natural product biochemistry
Ellis C. O’Neill, Martin Trick, Lionel Hill, Martin Rejzek, Renata G. Dusi, Chris J. Hamilton, Paul V. Zimba, Bernard Henrissat and Robert A. Field
DOI: 10.1039/C5MB00319A

Evolutionary game theory: cells as players
Sabine Hummert, Katrin Bohl, David Basanta, Andreas Deutsch, Sarah Werner, Günter Theißen, Anja Schroeter and Stefan Schuster
DOI: 10.1039/C3MB70602H

Fatty acid biosynthesis revisited: structure elucidation and metabolic engineering
Joris Beld, D. John Lee and Michael D. Burkart
DOI: 10.1039/C4MB00443D

Exploration of the HIF-1α/p300 interface using peptide and Adhiron phage display technologies
Hannah F. Kyle, Kate F. Wickson, Jonathan Stott, George M. Burslem, Alexander L. Breeze, Christian Tiede, Darren C. Tomlinson, Stuart L. Warriner, Adam Nelson, Andrew J. Wilson and Thomas A. Edwards
DOI: 10.1039/C5MB00284B

Next generation sequencing: implications in personalized medicine and pharmacogenomics
Bahareh Rabbani, Hirofumi Nakaoka, Shahin Akhondzadeh, Mustafa Tekin and Nejat Mahdieh
DOI: 10.1039/C6MB00115G

A quinazoline-based HDAC inhibitor affects gene expression pathways involved in cholesterol biosynthesis and mevalonate in prostate cancer cells
Z. Lin, K. S. Bishop, H. Sutherland, G. Marlow, P. Murray, W. A. Denny and L. R. Ferguson
DOI: 10.1039/C5MB00554J

Systems biology analysis of hepatitis C virus infection reveals the role of copy number increases in regions of chromosome 1q in hepatocellular carcinoma metabolism
Ibrahim E. Elsemman, Adil Mardinoglu, Saeed Shoaie, Taysir H. Soliman and Jens Nielsen
DOI: 10.1039/C5MB00827A

Logical modelling of Drosophila signalling pathways
Abibatou Mbodj, Guillaume Junion, Christine Brun, Eileen E. M. Furlong and Denis Thieffry
DOI: 10.1039/C3MB70187E

Evolutionary game theory: molecules as players
Katrin Bohl, Sabine Hummert, Sarah Werner, David Basanta, Andreas Deutsch, Stefan Schuster, Günter Theißen and Anja Schroeter
DOI: 10.1039/C3MB70601J

Metabolomics in diabetic complications
Laura A. Filla and James L. Edwards
DOI: 10.1039/C6MB00014B

Hierarchical control of coherent gene clusters defines the molecular mechanisms of glioblastoma
Igor F. Tsigelny, Valentina L. Kouznetsova, Pengfei Jiang, Sandeep C. Pingle and Santosh Kesari
DOI: 10.1039/C5MB00007F

Connecting gene expression data from connectivity map and in silico target predictions for small molecule mechanism-of-action analysis
Aakash Chavan Ravindranath, Nolen Perualila-Tan, Adetayo Kasim, Georgios Drakakis, Sonia Liggi, Suzanne C. Brewerton, Daniel Mason, Michael J. Bodkin, David A. Evans, Aditya Bhagwat, Willem Talloen, Hinrich W. H. Göhlmann, QSTAR Consortium, Ziv Shkedy and Andreas Bender
DOI: 10.1039/C4MB00328D

The ring residue proline 8 is crucial for the thermal stability of the lasso peptide caulosegnin II
Julian D. Hegemann, Christopher D. Fage, Shaozhou Zhu, Klaus Harms, Francesco Saverio Di Leva, Ettore Novellino, Luciana Marinelli and Mohamed A. Marahiel
DOI: 10.1039/C6MB00081A

Differential protein profile in sexed bovine semen: shotgun proteomics investigation
Michele De Canio, Alessio Soggiu, Cristian Piras, Luigi Bonizzi, Andrea Galli, Andrea Urbani and Paola Roncada
DOI: 10.1039/C3MB70306A

Comprehensive mapping of O-GlcNAc modification sites using a chemically cleavable tag
Matthew E. Griffin, Elizabeth H. Jensen, Daniel E. Mason, Courtney L. Jenkins, Shannon E. Stone, Eric C. Peters and Linda C. Hsieh-Wilson
DOI: 10.1039/C6MB00138F

A genome-scale metabolic model of Methanococcus maripaludis S2 for CO2 capture and conversion to methane
Nishu Goyal, Hanifah Widiastuti, I. A. Karimi and Zhi Zhou
DOI: 10.1039/C3MB70421A

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What are your colleagues reading in Molecular BioSystems?

The articles below are some of the most read Molecular BioSystems articles in January, February and March 2016.

Isothermal amplified detection of DNA and RNA
Lei Yan, Jie Zhou, Yue Zheng, Adam S. Gamson, Benjamin T. Roembke, Shizuka Nakayama and Herman O. Sintim
DOI: 10.1039/C3MB70304E, Review Article

Why phosphoproteomics is still a challenge
Fiorella A. Solari, Margherita Dell’Aica, Albert Sickmann and René P. Zahedi
DOI: 10.1039/C5MB00024F, Opinion

Exploration of the HIF-1α/p300 interface using peptide and Adhiron phage display technologies
Hannah F. Kyle, Kate F. Wickson, Jonathan Stott, George M. Burslem, Alexander L. Breeze, Christian Tiede, Darren C. Tomlinson, Stuart L. Warriner, Adam Nelson, Andrew J. Wilson and Thomas A. Edwards
DOI: 10.1039/C5MB00284B, Paper

PLS/OPLS models in metabolomics: the impact of permutation of dataset rows on the K-fold cross-validation quality parameters
Mohamed N. Triba, Laurence Le Moyec, Roland Amathieu, Corentine Goossens, Nadia Bouchemal, Pierre Nahon, Douglas N. Rutledge and Philippe Savarin
DOI: 10.1039/C4MB00414K, Opinion

The PI3K/AKT/mTOR interactive pathway
Tulin Ersahin, Nurcan Tuncbag and Rengul Cetin-Atalay
DOI: 10.1039/C5MB00101C, Paper

Trials and tribulations of ‘omics data analysis: assessing quality of SIMCA-based multivariate models using examples from pulmonary medicine
Åsa M. Wheelock and Craig E. Wheelock
DOI: 10.1039/C3MB70194H, Opinion

The transcriptome of Euglena gracilis reveals unexpected metabolic capabilities for carbohydrate and natural product biochemistry
Ellis C. O’Neill, Martin Trick, Lionel Hill, Martin Rejzek, Renata G. Dusi, Chris J. Hamilton, Paul V. Zimba, Bernard Henrissat and Robert A. Field
DOI: 10.1039/C5MB00319A, Paper

Bridging the layers: towards integration of signal transduction, regulation and metabolism into mathematical models
Emanuel Gonçalves, Joachim Bucher, Anke Ryll, Jens Niklas, Klaus Mauch, Steffen Klamt, Miguel Rocha and Julio Saez-Rodriguez
DOI: 10.1039/C3MB25489E, Review Article

Metabolomic analysis of riboswitch containing E. coli recombinant expression system
Howbeer Muhamadali, Yun Xu, Rosa Morra, Drupad K. Trivedi, Nicholas J. W. Rattray, Neil Dixon and Royston Goodacre
DOI: 10.1039/C5MB00624D, Paper

Mechanism of action-based classification of antibiotics using high-content bacterial image analysis
Kelly C. Peach, Walter M. Bray, Dustin Winslow, Peter F. Linington and Roger G. Linington
DOI: 10.1039/C3MB70027E, Paper

(more…)

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What are your colleagues reading in Molecular BioSystems?

The articles below are the most read Molecular BioSystems articles in July, August and September 2015.

Isothermal amplified detection of DNA and RNA
Lei Yan, Jie Zhou, Yue Zheng, Adam S. Gamson, Benjamin T. Roembke, Shizuka Nakayama and Herman O. Sintim
DOI: 10.1039/C3MB70304E, Review Article

Bridging the layers: towards integration of signal transduction, regulation and metabolism into mathematical models
Emanuel Gonçalves, Joachim Bucher, Anke Ryll, Jens Niklas, Klaus Mauch, Steffen Klamt, Miguel Rocha and Julio Saez-Rodriguez
DOI: 10.1039/C3MB25489E, Review Article

Why phosphoproteomics is still a challenge
Fiorella A. Solari, Margherita Dell’Aica, Albert Sickmann and René P. Zahedi
DOI: 10.1039/C5MB00024F, Opinion

Fatty acid biosynthesis revisited: structure elucidation and metabolic engineering
Joris Beld, D. John Lee and Michael D. Burkart
DOI: 10.1039/C4MB00443D, Review Article

Mechanism of action-based classification of antibiotics using high-content bacterial image analysis
Kelly C. Peach, Walter M. Bray, Dustin Winslow, Peter F. Linington and Roger G. Linington
DOI: 10.1039/C3MB70027E, Paper

Differential protein profile in sexed bovine semen: shotgun proteomics investigation
Michele De Canio, Alessio Soggiu, Cristian Piras, Luigi Bonizzi, Andrea Galli, Andrea Urbani and Paola Roncada
DOI: 10.1039/C3MB70306A, Paper

Connecting gene expression data from connectivity map and in silico target predictions for small molecule mechanism-of-action analysis
Aakash Chavan Ravindranath, Nolen Perualila-Tan, Adetayo Kasim, Georgios Drakakis, Sonia Liggi, Suzanne C. Brewerton, Daniel Mason, Michael J. Bodkin, David A. Evans, Aditya Bhagwat, Willem Talloen, Hinrich W. H. Göhlmann, QSTAR Consortium, Ziv Shkedy and Andreas Bender
DOI: 10.1039/C4MB00328D, Paper

NMR- and MS-based metabolomics: various organ responses following naphthalene intervention
Yee Soon Ling, Hao-Jan Liang, Meng-Hsuan Chung, Ming-Huan Lin and Ching-Yu Lin
DOI: 10.1039/C4MB00090K, Paper

Multifunctional polymeric micelles with folate-mediated cancer cell targeting and pH-triggered drug releasing properties for active intracellular drug delivery
Younsoo Bae, Woo-Dong Jang, Nobuhiro Nishiyama, Shigeto Fukushima and Kazunori Kataoka
DOI: 10.1039/B500266D, Paper

Development of novel assays for lignin degradation: comparative analysis of bacterial and fungal lignin degraders
Mark Ahmad, Charles R. Taylor, David Pink, Kerry Burton, Daniel Eastwood, Gary D. Bending and Timothy D. H. Bugg
DOI: 10.1039/B908966G, Paper

(more…)

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What are your colleagues reading in Molecular BioSystems?

The articles below are the most read Molecular BioSystems articles in July, August and September 2014.

Isothermal amplified detection of DNA and RNA
Lei Yan, Jie Zhou, Yue Zheng, Adam S. Gamson, Benjamin T. Roembke, Shizuka Nakayama and Herman O. Sintim 
DOI: 10.1039/C3MB70304E

Logical modelling of Drosophila signalling pathways
Abibatou Mbodj, Guillaume Junion, Christine Brun, Eileen E. M. Furlong and Denis Thieffry
DOI: 10.1039/C3MB70187E

Concerted bioinformatic analysis of the genome-scale blood transcription factor compendium reveals new control mechanisms
Anagha Joshi and Berthold Gottgens  
DOI: 10.1039/C4MB00354C

A metabolomics approach for predicting the response to neoadjuvant chemotherapy in cervical cancer patients
Yan Hou, Mingzhu Yin, Fengyu Sun, Tao Zhang, Xiaohua Zhou, Huiyan Li, Jian Zheng, Xiuwei Chen, Cong Li, Xiaoming Ning, Ge Lou and Kang Li  
DOI: 10.1039/C4MB00054D

Bridging the layers: towards integration of signal transduction, regulation and metabolism into mathematical models
Emanuel Gonçalves, Joachim Bucher, Anke Ryll, Jens Niklas, Klaus Mauch, Steffen Klamt, Miguel Rocha and Julio Saez-Rodriguez 
DOI: 10.1039/C3MB25489E

Structure-based virtual screening of novel, high-affinity BRD4 inhibitors
Charuvaka Muvva, E. R. Azhagiya Singam, S. Sundar Raman and V. Subramanian
DOI: 10.1039/C4MB00243A

Trials and tribulations of ‘omics data analysis: assessing quality of SIMCA-based multivariate models using examples from pulmonary medicine
Åsa M. Wheelock and Craig E. Wheelock 
DOI: 10.1039/C3MB70194H

Differential protein profile in sexed bovine semen: shotgun proteomics investigation
Michele De Canio, Alessio Soggiu, Cristian Piras, Luigi Bonizzi, Andrea Galli, Andrea Urbani and Paola Roncada  
DOI: 10.1039/C3MB70306A

Crosstalk between kinases and Nedd4 family ubiquitin ligases
Heeseon An, David T. Krist and Alexander V. Statsyuk 
DOI: 10.1039/C3MB70572B

Mechanism of action-based classification of antibiotics using high-content bacterial image analysis
Kelly C. Peach, Walter M. Bray, Dustin Winslow, Peter F. Linington and Roger G. Linington  
DOI: 10.1039/C3MB70027E

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Q2 Top Ten most accessed articles

During the months April – June 2014, the most downloaded Molecular BioSystems articles were:

Isothermal amplified detection of DNA and RNA
Lei Yan, Jie Zhou, Yue Zheng, Adam S. Gamson, Benjamin T. Roembke, Shizuka Nakayama and Herman O. Sintim
DOI: 10.1039/C3MB70304E

Bridging the layers: towards integration of signal transduction, regulation and metabolism into mathematical models
Emanuel Gonçalves, Joachim Bucher, Anke Ryll, Jens Niklas, Klaus Mauch, Steffen Klamt, Miguel Rocha and Julio Saez-Rodriguez
DOI: 10.1039/C3MB25489E

TGF-β upregulates miR-182 expression to promote gallbladder cancer metastasis by targeting CADM1
Yinghe Qiu, Xiangji Luo, Tong Kan, Yongjie Zhang, Wenlong Yu, Yongpeng Wei, Ningjia Shen, Bin Yi and Xiaoqing Jiang
DOI: 10.1039/C3MB70479C

A cyclic dinucleotide containing 2-aminopurine is a general fluorescent sensor for c-di-GMP and 3′,3′-cGAMP
Benjamin T. Roembke, Jie Zhou, Yue Zheng, David Sayre, Allan Lizardo, Laurentee Bernard and Herman O. Sintim
DOI: 10.1039/C3MB70518H

Crosstalk between kinases and Nedd4 family ubiquitin ligases
Heeseon An, David T. Krist and Alexander V. Statsyuk
DOI: 10.1039/C3MB70572B

Logical modelling of Drosophila signalling pathways
Abibatou Mbodj, Guillaume Junion, Christine Brun, Eileen E. M. Furlong and Denis Thieffry
DOI: 10.1039/C3MB70187E

Trials and tribulations of ‘omics data analysis: assessing quality of SIMCA-based multivariate models using examples from pulmonary medicine
Åsa M. Wheelock and Craig E. Wheelock
DOI: 10.1039/C3MB70194H

Peroxisomes are juxtaposed to strategic sites on mitochondria
Yifat Cohen, Yoel Alexander Klug, Lazar Dimitrov, Zohar Erez, Silvia G. Chuartzman, Dalia Elinger, Ido Yofe, Kareem Soliman, Jutta Gärtner, Sven Thoms, Randy Schekman, Yael Elbaz-Alon, Einat Zalckvar and Maya Schuldiner
DOI: 10.1039/C4MB00001C

A genome-scale metabolic model of Methanococcus maripaludis S2 for CO2 capture and conversion to methane
Nishu Goyal, Hanifah Widiastuti, I. A. Karimi and Zhi Zhou
DOI: 10.1039/C3MB70421A

A time resolved metabolomics study: the influence of different carbon sources during growth and starvation of Bacillus subtilis
Hanna Meyer, Hendrikje Weidmann, Ulrike Mäder, Michael Hecker, Uwe Völker and Michael Lalk
DOI: 10.1039/C4MB00112E

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Q1 Top Ten most accessed Molecular BioSystems articles

During January, February and March this year, the following articles were the Top Ten most accessed:

Bridging the layers: towards integration of signal transduction, regulation and metabolism into mathematical models
Emanuel Gonçalves, Joachim Bucher, Anke Ryll, Jens Niklas, Klaus Mauch, Steffen Klamt, Miguel Rocha and Julio Saez-Rodriguez  
Mol. BioSyst., 2013,9, 1576-1583
DOI: 10.1039/c3mb25489e

The powerful law of the power law and other myths in network biology
Gipsi Lima-Mendez and Jacques van Helden  
Mol. BioSyst., 2009,5, 1482-1493
DOI: 10.1039/b908681a

Crosstalk between kinases and Nedd4 family ubiquitin ligases
Heeseon An, David T. Krist and Alexander V. Statsyuk  
Mol. BioSyst., 2014, Advance Article
DOI: 10.1039/c3mb70572b

A novel paradigm for potential drug-targets discovery: quantifying relationships of enzymes and cascade interactions of neighboring biological processes to identify drug-targets
Lina Chen, Qian Wang, Liangcai Zhang, Jingxie Tai, Hong Wang, Wan Li, Xu Li, Weiming He and Xia Li  
Mol. BioSyst., 2011,7, 1033-1041
DOI: 10.1039/c0mb00249f

Isothermal amplified detection of DNA and RNA
Lei Yan, Jie Zhou, Yue Zheng, Adam S. Gamson, Benjamin T. Roembke, Shizuka Nakayama and Herman O. Sintim  
Mol. BioSyst., 2014,10, 970-1003
DOI: 10.1039/c3mb70304e

Metabolic footprint analysis of recombinant Escherichia coli strains during fed-batch fermentations
Sónia Carneiro, Silas G. Villas-Bôas, Eugénio C. Ferreira and Isabel Rocha  
Mol. BioSyst., 2011,7, 899-910
DOI: 10.1039/c0MB00143k

Creating functional engineered variants of the single-module non-ribosomal peptide synthetase IndC by T domain exchange
Ralf Beer, Konrad Herbst, Nikolaos Ignatiadis, Ilia Kats, Lorenz Adlung, Hannah Meyer, Dominik Niopek, Tania Christiansen, Fanny Georgi, Nils Kurzawa, Johanna Meichsner, Sophie Rabe, Anja Riedel, Joshua Sachs, Julia Schessner, Florian Schmidt, Philipp Walch, Katharina Niopek, Tim Heinemann, Roland Eils and Barbara Di Ventura
Mol. BioSyst., 2014, Advance Article
DOI: 10.1039/c3mb70594c

Adjustment of carbon fluxes to light conditions regulates the daily turnover of starch in plants: a computational model
Alexandra Pokhilko, Anna Flis, Ronan Sulpice, Mark Stitt and Oliver Ebenhöh
Mol. BioSyst., 2014,10, 613-627
DOI: 10.1039/c3mb70459a

Engineering reduced evolutionary potential for synthetic biology
Brian A. Renda, Michael J. Hammerling and Jeffrey E. Barrick
Mol. BioSyst., 2014, Advance Article
DOI: 10.1039/c3mb70606k

Combining radiation, immunotherapy, and antiangiogenesis agents in the management of cancer: the Three Musketeers or just another quixotic combination?
Mitchell Kamrava, Michael B. Bernstein, Kevin Camphausen and James W. Hodge  
Mol. BioSyst., 2009,5, 1262-1270
DOI: 10.1039/b911313b

If you have any thoughts or comments on any of these articles, please leave these in the box below.

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Top ten most accessed MBS articles in Q4 2013

Top ten most accessed articles from October – December 2013

Reverse engineering of metabolic networks, a critical assessment 
Diana M. Hendrickx, Margriet M. W. B. Hendriks, Paul H. C. Eilers, Age K. Smilde and Huub C. J. Hoefsloot    
Mol. BioSyst., 2011,7, 511-520 
DOI: 10.1039/C0MB00083C    

Identification and comparative analysis of hepatitis C virus–host cell protein interactions 
Patrick T. Dolan, Chaoying Zhang, Sudip Khadka, Vaithilingaraja Arumugaswami, Abbey D. Vangeloff, Nicholas S. Heaton, Sudhir Sahasrabudhe, Glenn Randall, Ren Sun and Douglas J. LaCount    
Mol. BioSyst., 2013,9, 3199-3209 
DOI: 10.1039/C3MB70343F     

Mass spectrometry-based identification and characterisation of lysine and arginine methylation in the human proteome 
Michael Bremang, Alessandro Cuomo, Anna Maria Agresta, Magdalena Stugiewicz, Valeria Spadotto and Tiziana Bonaldi    
Mol. BioSyst., 2013,9, 2231-2247 
DOI: 10.1039/C3MB00009E     

Activity-based protein profiling of secreted cellulolytic enzyme activity dynamics in Trichoderma reesei QM6a, NG14, and RUT-C30 
Lindsey N. Anderson, David E. Culley, Beth A. Hofstad, Lacie M. Chauvigné-Hines, Erika M. Zink, Samuel O. Purvine, Richard D. Smith, Stephen J. Callister, Jon M. Magnuson and Aaron T. Wright    
Mol. BioSyst., 2013,9, 2992-3000 
DOI: 10.1039/C3MB70333A     

Bridging the layers: towards integration of signal transduction, regulation and metabolism into mathematical models 
Emanuel Gonçalves, Joachim Bucher, Anke Ryll, Jens Niklas, Klaus Mauch, Steffen Klamt, Miguel Rocha and Julio Saez-Rodriguez    
Mol. BioSyst., 2013,9, 1576-1583 
DOI: 10.1039/C3MB25489E     

Optogenetic tools for mammalian systems 
Konrad Müller and Wilfried Weber    
Mol. BioSyst., 2013,9, 596-608 
DOI: 10.1039/C3MB25590E    

Expanding the chemistry of fluorescent protein biosensors through genetic incorporation of unnatural amino acids 
Wei Niu and Jiantao Guo    
Mol. BioSyst., 2013,9, 2961-2970 
DOI: 10.1039/C3MB70204A    

Sirtuin 6: a review of biological effects and potential therapeutic properties 
Jade M. Beauharnois, Beatriz E. Bolívar and John T. Welch    
Mol. BioSyst., 2013,9, 1789-1806 
DOI: 10.1039/C3MB00001J     

Real-time probing of ß-amyloid self-assembly and inhibition using fluorescence self-quenching between neighbouring dyes 
Steven D. Quinn, Paul A. Dalgarno, Ryan T. Cameron, Gordon J. Hedley, Christian Hacker, John M. Lucocq, George S. Baillie, Ifor D. W. Samuel and J. Carlos Penedo    
Mol. BioSyst., 2014,10, 34-44 
DOI: 10.1039/C3MB70272C    

Analysis of omics data with genome-scale models of metabolism 
Daniel R. Hyduke, Nathan E. Lewis and Bernhard Ø. Palsson    
Mol. BioSyst., 2013,9, 167-174 
DOI: 10.1039/C2MB25453K    

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to Molecular BioSystems? Then why not submit to us today or alternatively email us your suggestions.

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Top ten most accessed MBS articles in Q3 2013

This month sees the following articles in Molecular BioSystems that are in the top ten most accessed July – September:-

Mass spectrometry-based identification and characterisation of lysine and arginine methylation in the human proteome
Michael Bremang, Alessandro Cuomo, Anna Maria Agresta, Magdalena Stugiewicz, Valeria Spadotto and Tiziana Bonaldi
Mol. BioSyst., 2013,9, 2231-2247
DOI: 10.1039/C3LC90080K

Secretome profiling with antibody microarrays
Shakhawan Abdulrahman Mustafa, Jörg D. Hoheisel and Mohamed Saiel Saeed Alhamdani
Mol. BioSyst., 2011,7, 1795-1801
DOI: 10.1039/C3LC90080K

Network representations and methods for the analysis of chemical and biochemical pathways
Conner I. Sandefur, Maya Mincheva and Santiago Schnell
Mol. BioSyst., 2013,9, 2189-2200
DOI: 10.1039/C3MB70052F

Sirtuin 6: a review of biological effects and potential therapeutic properties
Jade M. Beauharnois, Beatriz E. Bolívar and John T. Welch
Mol. BioSyst., 2013,9, 1789-1806
DOI: 10.1039/C3MB00001J

Split-superpositive GFP reassembly is a fast, efficient, and robust method for detecting protein–protein interactions in vivo
Brett D. Blakeley, Alex M. Chapman and Brian R. McNaughton
Mol. BioSyst., 2012,8, 2036-2040
DOI: 10.1039/C2MB25130B

Optogenetic tools for mammalian systems
Konrad Müller and Wilfried Weber
Mol. BioSyst., 2013,9, 596-608
DOI: 10.1039/C3MB25590E

Chemical biology-based approaches on fluorescent labeling of proteins in live cells
Deokho Jung, Kyoungmi Min, Juyeon Jung, Wonhee Jang and Youngeun Kwon
Mol. BioSyst., 2013,9, 862-872
DOI: 10.1039/C2MB25422K

Global signatures of protein and mRNA expression levels
Raquel de Sousa Abreu, Luiz O. Penalva, Edward M. Marcotte and Christine Vogel
Mol. BioSyst., 2009,5, 1512-1526
DOI: 10.1039/B908315D

Selective inhibition of the unfolded protein response: targeting catalytic sites for Schiff base modification
Susana M. Tomasio, Heather P. Harding, David Ron, Benedict C. S. Cross and Peter J. Bond
Mol. BioSyst., 2013,9, 2408-2416
DOI: 10.1039/C3MB70234K

Analysis of omics data with genome-scale models of metabolism
Daniel R. Hyduke, Nathan E. Lewis and Bernhard Ø. Palsson
Mol. BioSyst., 2013,9, 167-174
DOI: 10.1039/C2MB25453K

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Top ten most accessed MBS articles in Q2 2013

This month sees the following articles in Molecular BioSystems that are in the top ten most accessed April-June:-

Cell-penetrating peptides (CPPs) as a vector for the delivery of siRNAs into cells
Ikuhiko Nakase, Gen Tanaka and Shiroh Futaki
Mol. BioSyst., 2013,9, 855-861
DOI: 10.1039/C2MB25467K

Sirtuin 6: a review of biological effects and potential therapeutic properties
Ikuhiko Nakase, Gen Tanaka and Shiroh Futaki
Mol. BioSyst., 2013,9, 855-861
DOI: 10.1039/C3MB00001J

Chemical biology-based approaches on fluorescent labeling of proteins in live cells
Deokho Jung, Kyoungmi Min, Juyeon Jung, Wonhee Jang and Youngeun Kwon
Mol. BioSyst., 2013,9, 862-872
DOI: 10.1039/C2MB25422K

Multicolor single-molecule FRET to explore protein folding and binding
Yann Gambin and Ashok A. Deniz
Mol. BioSyst., 2010,6, 1540-1547
DOI: 10.1039/C003024D

Split-superpositive GFP reassembly is a fast, efficient, and robust method for detecting protein–protein interactions in vivo
Brett D. Blakeley, Alex M. Chapman and Brian R. McNaughton
Mol. BioSyst., 2012,8, 2036-2040
DOI: 10.1039/C2MB25130B

Multifunctional polymeric micelles with folate-mediated cancer cell targeting and pH-triggered drug releasing properties for active intracellular drug delivery
Younsoo Bae, Woo-Dong Jang, Nobuhiro Nishiyama, Shigeto Fukushima and Kazunori Kataoka
Mol. BioSyst., 2005,1, 242-250
DOI: 10.1039/B500266D

Bridging the layers: towards integration of signal transduction, regulation and metabolism into mathematical models
Emanuel Gonçalves, Joachim Bucher, Anke Ryll, Jens Niklas, Klaus Mauch, Steffen Klamt, Miguel Rocha and Julio Saez-Rodriguez
Mol. BioSyst., 2013,9, 1576-1583
DOI: 10.1039/C3MB25489E

Salmonella modulates metabolism during growth under conditions that induce expression of virulence genes
Young-Mo Kim, Brian J. Schmidt, Afshan S. Kidwai, Marcus B. Jones, Brooke L. Deatherage Kaiser, Heather M. Brewer, Hugh D. Mitchell, Bernhard O. Palsson, Jason E. McDermott, Fred Heffron, Richard D. Smith, Scott N. Peterson, Charles Ansong, Daniel R. Hyduke, Thomas O. Metz and Joshua N. Adkins
Mol. BioSyst., 2013,9, 1522-1534
DOI: 10.1039/C3MB25598K

Target identification of small molecules based on chemical biology approaches
Yushi Futamura, Makoto Muroi and Hiroyuki Osada
Mol. BioSyst., 2013,9, 897-914
DOI: 10.1039/C2MB25468A

LC-MS-based metabolomics
Bin Zhou, Jun Feng Xiao, Leepika Tuli and Habtom W. Ressom
Mol. BioSyst., 2012,8, 470-481
DOI: 10.1039/C1MB05350G

Why not take a look at the articles today and blog your thoughts and comments below.

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Top ten most accessed MBS articles in January 2013

This month sees the following articles in Molecular BioSystems that are in the top ten most accessed:-

Analysis of omics data with genome-scale models of metabolism 
Daniel R. Hyduke, Nathan E. Lewis and Bernhard Ø. Palsson 
Mol. BioSyst., 2013, 9, 167-174 
DOI: 10.1039/C2MB25453K  
 
Predicting cancer drug mechanisms of action using molecular network signatures 
Justin R. Pritchard, Peter M. Bruno, Michael T. Hemann and Douglas A. Lauffenburger 
Mol. BioSyst., 2013, Advance Article 
DOI: 10.1039/C2MB25459J  
 
Learning the molecular mechanisms of the reprogramming factors: let’s start from microRNAs 
Chao-Shun Yang and Tariq M. Rana  
Mol. BioSyst., 2013, 9, 10-17 
DOI: 10.1039/C2MB25088H  

Building synthetic gene circuits from combinatorial libraries: screening and selection strategies 
Yolanda Schaerli and Mark Isalan  
Mol. BioSyst., 2013, Advance Article 
DOI: 10.1039/C2MB25483B  
 
Network motifs provide signatures that characterize metabolism 
Erin R. Shellman, Charles F. Burant and Santiago Schnell  
Mol. BioSyst., 2013, 9, 352-360 
DOI: 10.1039/C2MB25346A  
 
Split-superpositive GFP reassembly is a fast, efficient, and robust method for detecting protein – protein interactions in vivo 
Brett D. Blakeley, Alex M. Chapman and Brian R. McNaughton  
Mol. BioSyst., 2012, 8, 2036-2040 
DOI: 10.1039/C2MB25130B  
 
Analysis of temporal patterns of GPCR–ß-arrestin interactions using split luciferase-fragment complementation 
Mitsuru Hattori, Miho Tanaka, Hideo Takakura, Kiyono Aoki, Kenji Miura, Tomohiro Anzai and Takeaki Ozawa  
Mol. BioSyst., 2013, Advance Article 
DOI: 10.1039/C2MB25443C  

Non-traditional roles of G-protein-coupled receptors in basic cell biology 
Xin Zhang and Ulrike S. Eggert  
Mol. BioSyst., 2013, 9, 586-595 
DOI: 10.1039/C2MB25429H  

Engineering Ecosystems and Synthetic Ecologies 
Michael T. Mee and Harris H. Wang  
Mol. BioSyst., 2012, 8, 2470-2483 
DOI: 10.1039/C2MB25133G  
 
Systematic analysis of histone modification readout 
Miroslav Nikolov and Wolfgang Fischle 
Mol. BioSyst., 2013, 9, 182-194 
DOI: 10.1039/C2MB25328C  

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to Molecular BioSystems? Then why not submit to us today or alternatively email us your suggestions.

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