This is followed by an Opinion piece from Matthias Gstaiger and Ruedi Aebersold at ETH Zurich, Switzerland, on the increasing understanding of genotype-phenotype relationships due to deciphering proteome organisation.
Digital and analogical reality in proteomics investigation
Andrea Urbani, Massimo Castagnola, Mauro Fasano, Luca Bini, Alessandra Modesti, Anna Maria Timperio and Paola Roncada
Genotype–phenotype relationships in light of a modular protein interaction landscape
Matthias Gstaiger and Ruedi Aebersold
Amongst the three review articles in this Proteomics themed issue, a HOT review article by Jorg Stulke et al. at Georg-August-Universitat Gottingen, Germany, is featured on the front cover. This review taking a fresh look at the genes and proteins of Bacillus subtilis was featured on the blog recently. It highlights the difficulties with defining the essential genes of a particular organism.
Essential genes in Bacillus subtilis: a re-evaluation after ten years
Fabian M. Commichau, Nico Pietack and Jörg Stülke
The inside front cover features work from Damiana Pieragostino et al. in Italy in which shotgun proteomics is used to provide a profile of the proteins in the tears of patients with primary open angle glaucoma. They find a mix of inflammatory proteins as possible biomarkers for early diagnosis of the disease, which is a major global cause of blindness.
Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy
Damiana Pieragostino, Luca Agnifili, Vincenzo Fasanella, Simona D’Aguanno, Rodolfo Mastropasqua, Carmine Di Ilio, Paolo Sacchetta, Andrea Urbani and Piero Del Boccio