Archive for the ‘News’ Category

Seasons Greetings from Molecular BioSystems!

The holidays are nearly here!!

We know everyone’s been working hard to finish off semesters and write up those papers. Here in Cambridge we’ve been working hard too, planning for the New Year and wrapping up 2013. To spread the holiday cheer, we’ve chosen three highly accessed papers and made them *FREE TO ACCESS* for the next four weeks. Enjoy!

Merry Christmas from the MBS team!



Paper: Activity-based protein profiling of secreted cellulolytic enzyme activity dynamics in Trichoderma reesei QM6a, NG14, and RUT-C30, by Aaron T. Wright, Pacific Northwest National Laboratory

Paper: The structural properties of DNA regulate gene expression, by Sattar Soltani, Shahid Beheshti University

Paper: Integrated gene co-expression network analysis in the growth phase of Mycobacterium tuberculosis reveals new potential drug targets, by Srinivasan Ramachandran, Institute of Genomics and Integrative Biology, Delhi


Access is free through a registered RSC account – click here to register

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Free to access HOT articles!

These HOT articles have been recommended by our referees and are free to access for 4 weeks*

An in silico exploration of the interaction mechanism of pyrazolo[1,5-a]pyrimidine type CDK2 inhibitors
Yan Li, Weimin Gao, Feng Li, Jinghui Wang, Jingxiao Zhang, Yinfeng Yang, Shuwei Zhang and Ling Yang  
DOI: 10.1039/C3MB70186G 

GA 

Theoretical study on the interaction of pyrrolopyrimidine derivatives as LIMK2 inhibitors: insight into structure-based inhibitor design
Mingyun Shen, Shunye Zhou, Youyong Li, Dan Li and Tingjun Hou
DOI: 10.1039/C3MB70168A

GA

Selective inhibition of the unfolded protein response: targeting catalytic sites for Schiff base modification
Susana M. Tomasio, Heather P. Harding, David Ron, Benedict C. S. Cross and Peter J. Bond 
DOI: 10.1039/C3MB70234K

GA

The three-dimensional context of a double helix determines the fluorescence of the internucleoside-tethered pair of fluorophores
Valeri Metelev, Surong Zhang, David Tabatadze, Anand T. N. Kumar and Alexei Bogdanov
DOI: 10.1039/C3MB70108E

GA 

BH3 helix-derived biophotonic nanoswitches regulate cytochrome c release in permeabilised cells
Robert J. Mart, Rachel J. Errington, Catherine L. Watkins, Sally C. Chappell, Marie Wiltshire, Arwyn T. Jones, Paul J. Smith and Rudolf K. Allemann  
DOI: 10.1039/C3MB70246D

GA

Metabolomic identification of diagnostic plasma biomarkers in humans with chronic heart failure

Juan Wang, Zhongfeng Li, Jianxin Chen, Huihui Zhao, Liangtao Luo, Chan Chen, Xuegong Xu, Wenting Zhang, Kuo Gao, Bin Li, Junpeng Zhang and Wei Wang
DOI: 10.1039/C3MB70227H

GA

*Free access to individuals is provided through an RSC Publishing personal account. It’s quick, simple and more importantly – free – to register!

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Final chance to register for ISACS11 – don’t miss Shokat, Trauner, Yonath and many more!

Registration Deadline – Friday 21 June 2013

 

You have just a few days left to secure your place at the 11th conference in the International Symposia on Advancing the Chemical Sciences (ISACS) series as registration for Challenges in Chemical Biology (ISACS11) closes on Friday 21 June 2013.

Don’t miss your opportunity to join outstanding researchers from across the globe to explore the themes of immunology, microbiology, chromatin biology, epigenetics, cancer biology, systems biology and neuroscience.

Registration is quick and simple via the online booking system and spaces are filling up fast so be sure to guarantee yours now.

Programme Live

We are pleased to announce that the ISACS11 programme is now available to view online. Take a look at the schedule to discover the full speaker line up and stimulating lecture titles over the entire four days.

Find Out More

For the latest information on Challenges in Chemical Biology (ISACS11) or any of the conferences in the series, please sign up for the exclusive newsletter, follow ISACS on twitter or visit the dedicated webpage.

I look forward to welcoming you to Boston.

Best regards

Professor Ben Davis
Chairman of the Conference Committee
isacs@rsc.org

The International Symposia on Advancing the Chemical Sciences (ISACS) partner the RSC’s flagship journal Chemical Science – Winner of the ALPSP Award for Best New Journal 2011.

                    

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Medicinal Chemistry Residential School – early bird deadline approaching!

17- 21 June 2013, Loughborough University, UK

Don’t miss your chance to be part of the RSC Medicinal Chemistry Residential School, an intensive course which has trained some of the world’s leading medicinal chemists working in the pharmaceutical industry.

The early bird registration deadline of Monday 22 April 2013 is almost upon us. If you are a graduate or post-doctoral chemist with 1-5 years’ experience in the field of drug research or a final year PhD student in pharmacy and organic chemistry contemplating a career in medicinal chemistry, be sure to secure your space before this date to benefit from a great saving on the standard fee.

Please visit the dedicated webpage for full details about the RSC Medicinal Chemistry Residential School including the course programme, bursary applications and poster presentation opportunities.

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Top ten most accessed MBS articles in January 2013

This month sees the following articles in Molecular BioSystems that are in the top ten most accessed:-

Analysis of omics data with genome-scale models of metabolism 
Daniel R. Hyduke, Nathan E. Lewis and Bernhard Ø. Palsson 
Mol. BioSyst., 2013, 9, 167-174 
DOI: 10.1039/C2MB25453K  
 
Predicting cancer drug mechanisms of action using molecular network signatures 
Justin R. Pritchard, Peter M. Bruno, Michael T. Hemann and Douglas A. Lauffenburger 
Mol. BioSyst., 2013, Advance Article 
DOI: 10.1039/C2MB25459J  
 
Learning the molecular mechanisms of the reprogramming factors: let’s start from microRNAs 
Chao-Shun Yang and Tariq M. Rana  
Mol. BioSyst., 2013, 9, 10-17 
DOI: 10.1039/C2MB25088H  

Building synthetic gene circuits from combinatorial libraries: screening and selection strategies 
Yolanda Schaerli and Mark Isalan  
Mol. BioSyst., 2013, Advance Article 
DOI: 10.1039/C2MB25483B  
 
Network motifs provide signatures that characterize metabolism 
Erin R. Shellman, Charles F. Burant and Santiago Schnell  
Mol. BioSyst., 2013, 9, 352-360 
DOI: 10.1039/C2MB25346A  
 
Split-superpositive GFP reassembly is a fast, efficient, and robust method for detecting protein – protein interactions in vivo 
Brett D. Blakeley, Alex M. Chapman and Brian R. McNaughton  
Mol. BioSyst., 2012, 8, 2036-2040 
DOI: 10.1039/C2MB25130B  
 
Analysis of temporal patterns of GPCR–ß-arrestin interactions using split luciferase-fragment complementation 
Mitsuru Hattori, Miho Tanaka, Hideo Takakura, Kiyono Aoki, Kenji Miura, Tomohiro Anzai and Takeaki Ozawa  
Mol. BioSyst., 2013, Advance Article 
DOI: 10.1039/C2MB25443C  

Non-traditional roles of G-protein-coupled receptors in basic cell biology 
Xin Zhang and Ulrike S. Eggert  
Mol. BioSyst., 2013, 9, 586-595 
DOI: 10.1039/C2MB25429H  

Engineering Ecosystems and Synthetic Ecologies 
Michael T. Mee and Harris H. Wang  
Mol. BioSyst., 2012, 8, 2470-2483 
DOI: 10.1039/C2MB25133G  
 
Systematic analysis of histone modification readout 
Miroslav Nikolov and Wolfgang Fischle 
Mol. BioSyst., 2013, 9, 182-194 
DOI: 10.1039/C2MB25328C  

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to Molecular BioSystems? Then why not submit to us today or alternatively email us your suggestions.

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Madan Babu awarded 2014 Colworth Medal!

The 2014 Colworth Medal has been awarded to Molecular BioSystems Associate Editor Madan Babu for his exceptional expertise in bioinformatics analysis of protein structure and gene networks.

The Colworth Medal is an annual award from the Biochemical Society, presented to researchers under the age of 35 for their outstanding contribution to biochemical research. This prestigious award has been presented since 1963 with many extraordinary researchers being past recipients, and we are delighted that Madan is the recipient in its 50th year. This follows on from his Early Career Research Award from the Biochemical Society in 2010.

Madan continues to carry out such outstanding research and lead the Regulatory Genomics and Systems Biology group at the MRC Laboratory of Molecular Biology, Cambridge, UK. He will present his award lecture at the 2014 Biochemical Society conference.

Submit your work to Madan Babu’s editorial office today via our simple online submissions system: http://mc.manuscriptcentral.com/mb.

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Challenges in Chemical Biology (ISACS11) – Oral Abstract Deadline 15 March 2013

This is your last chance to submit an oral abstract for Challenges in Chemical Biology (ISACS11) which will be held on 23-26 July in Boston, USA.

Act before the deadline of Friday 15 March 2013 to take advantage of this exceptional opportunity to showcase your work alongside researchers from across the globe.

For details of speakers and conferences themes, please visit the dedicated website.

The second ISACS event of 2013 is building on the successes of ISACS5: Challenges in Chemical Biology.

The themes of ISACS11 include topics that are extremely relevant to readers and authors of Molecular BioSystems, such as chromatin biology & epigenetics, cancer biology, systems biology. The aim is to discuss the latest applications of chemical tools and techniques for probing biological problems.

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Top ten most accessed articles in August 2012

The following articles in Molecular BioSystems were in the top ten most accessed for August:

Metabolome 2.0: quantitative genetics and network biology of metabolic phenotypes
Marc-Emmanuel Dumas
Mol. BioSyst., 2012, 8, 2494-2502
DOI: 10.1039/C2MB25167A

Robust co-regulation of tyrosine phosphorylation sites on proteins reveals novel protein interactions
Kristen M. Naegle, Forest M. White, Douglas A. Lauffenburger and Michael B. Yaffe
Mol. BioSyst., 2012, 8, 2771-2782
DOI: 10.1039/C2MB25200G

Optimized TAL effector nucleases (TALENs) for use in treatment of sickle cell disease
Ning Sun, Jing Liang, Zhanar Abil and Huimin Zhao
Mol. BioSyst., 2012, 8, 1255-1263
DOI: 10.1039/C2MB05461B 

Upregulated MALAT-1 contributes to bladder cancer cell migration by inducing epithelial-to-mesenchymal transition
Liang Ying, Qi Chen, Yawei Wang, Zhihua Zhou, Yiran Huang and Feng Qiu
Mol. BioSyst., 2012, 8, 2289-2294
DOI: 10.1039/C2MB25070E

Synthetic lethal interactions in yeast reveal functional roles of J protein co-chaperones
Anne T. Gillies, Rebecca Taylor and Jason E. Gestwicki
Mol. BioSyst., 2012, 8, 2901-2908
DOI: 10.1039/C2MB25248A

Emerging investigators contributors 2012
Mol. BioSyst., 2012, 8, 2461-2465
DOI: 10.1039/C2MB90034C

Inhibitors targeting on cell wall biosynthesis pathway of MRSA
Haihong Hao, Guyue Cheng, Menghong Dai, Qinghua Wu and Zonghui Yuan
Mol. BioSyst., 2012, 8, 2828-2838
DOI: 10.1039/C2MB25188D

The changes of microRNA expression profiles and tyrosinase related proteins in MITF knocked down melanocytes
Ping Wang, Yong Li, Weisong Hong, Junhui Zhen, Jingping Ren, Zhao Li and Aie Xu
Mol. BioSyst., 2012, 8, 2924-2931
DOI: 10.1039/C2MB25228G

LC-MS-based metabolomics
Bin Zhou, Jun Feng Xiao, Leepika Tuli and Habtom W. Ressom
Mol. BioSyst., 2012, 8, 470-481
DOI: 10.1039/C1MB05350G

Large-scale quantitative glycoproteomics analysis of site-specific glycosylation occupancy
Sheng Pan, Yasuko Tamura, Ru Chen, Damon May, Martin W. McIntosh and Teresa A. Brentnall
Mol. BioSyst., 2012, 8, 2850-2856
DOI: 10.1039/C2MB25268F

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to Molecular BioSystems? Then why not submit to us today or alternatively email us your suggestions.

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Top ten most accessed articles in July 2012

This month sees the following articles in Molecular BioSystems that are in the top ten most accessed:

Optimized TAL effector nucleases (TALENs) for use in treatment of sickle cell disease  
Ning Sun, Jing Liang, Zhanar Abil and Huimin Zhao  
Mol. BioSyst., 2012, 8, 1255-1263
DOI: 10.1039/C2MB05461B  

Intramolecular three-colour single pair FRET of intrinsically disordered proteins with increased dynamic range  
Sigrid Milles, Christine Koehler, Yann Gambin, Ashok A. Deniz and Edward A. Lemke  
Mol. BioSyst., 2012, 8, 2531-2534
DOI: 10.1039/C2MB25135C  

Rewiring the dynamic interactome 
Melissa J. Davis, Chang Jin Shin, Ning Jing and Mark A. Ragan  
Mol. BioSyst., 2012, 8, 2054-2066
DOI: 10.1039/C2MB25050K  

Identification of DNA–protein complexes using an improved, combined western blotting-electrophoretic mobility shift assay (WEMSA) with a fluorescence imaging system  
Klaus Deckmann, Florian Rörsch, Gerd Geisslinger and Sabine Grösch  
Mol. BioSyst., 2012, 8, 1389-1395
DOI: 10.1039/C2MB05500G  

Upregulated MALAT-1 contributes to bladder cancer cell migration by inducing epithelial-to-mesenchymal transition  
Liang Ying, Qi Chen, Yawei Wang, Zhihua Zhou, Yiran Huang and Feng Qiu  
Mol. BioSyst., 2012, 8, 2289-2294
DOI: 10.1039/C2MB25070E  

Interaction and photo-induced cleavage studies of a copper based chemotherapeutic drug with human serum albumin: spectroscopic and molecular docking study    
Sartaj Tabassum, Waddhaah M. Al-Asbahy, Mohd. Afzal, Farukh Arjmand and Rizwan Hasan Khan  
Mol. BioSyst., 2012, 8, 2424-2433
DOI: 10.1039/C2MB25119A

Split-superpositive GFP reassembly is a fast, efficient, and robust method for detecting protein–protein interactions in vivo  
Brett D. Blakeley, Alex M. Chapman and Brian R. McNaughton  
Mol. BioSyst., 2012, 8, 2036-2040
DOI: 10.1039/C2MB25130B  

Structural analysis of intrinsically disordered proteins by small-angle X-ray scattering  
Pau Bernadó and Dmitri I. Svergun  
Mol. BioSyst., 2012, 8, 151-167
DOI: 10.1039/C1MB05275F  

Differential RNAi screening provides insights into the rewiring of signalling networks during oxidative stress  
Mar Arias Garcia, Miguel Sanchez Alvarez, Heba Sailem, Vicky Bousgouni, Julia Sero and Chris Bakal 
Mol. BioSyst., 2012, 8, 2605-2613
DOI: 10.1039/C2MB25092F  

Small-molecule modulators of the Sonic Hedgehog signaling pathway 
Benjamin Z. Stanton and Lee F. Peng  
Mol. BioSyst., 2010, 6, 44-54
DOI: 10.1039/B910196A  

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to Molecular BioSystems? Then why not submit to us today or alternatively email us your suggestions.

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Emerging Investigators 2012

Molecular BioSystems Emerging Investigators 2012We are delighted to publish our third themed issue dedicated to the work of new and emerging investigators whose research in chemical biology interfaces with the -omic sciences and systems biology.

There is plenty of exciting research in this issue, including work from Priscilla Yang on exploiting known kinase inhibitors to develop new probes for imaging kinases and Nuno Bandeira on spectral networks algorithms to analyse tandem mass spectroscopy results. Both these articles are free to access for the next four weeks.

For all the contributors to the issue please see our Profile article.

To coincide with this, Molecular BioSystems Deputy Editor Victoria Eyley has just returned from the International Conference on Systems Biology (ICSB) in Toronto, Canada where she presented this year’s Early Career Lectureship to Thijn Brummelkamp (The Netherlands Cancer Institute). Thijn is being recognised as he was one of the first to describe stable RNA interference, which is widely used to study gene function.

*Free access is provided to subscribing institutions or through an RSC Publishing Personal Account. Registration is quick and easy at http://pubs.rsc.org/en/account/register.

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