What are your colleagues reading in Molecular BioSystems?

The articles below are the most read Molecular BioSystems articles in July, August and September 2015.

Isothermal amplified detection of DNA and RNA
Lei Yan, Jie Zhou, Yue Zheng, Adam S. Gamson, Benjamin T. Roembke, Shizuka Nakayama and Herman O. Sintim
DOI: 10.1039/C3MB70304E, Review Article

Bridging the layers: towards integration of signal transduction, regulation and metabolism into mathematical models
Emanuel Gonçalves, Joachim Bucher, Anke Ryll, Jens Niklas, Klaus Mauch, Steffen Klamt, Miguel Rocha and Julio Saez-Rodriguez
DOI: 10.1039/C3MB25489E, Review Article

Why phosphoproteomics is still a challenge
Fiorella A. Solari, Margherita Dell’Aica, Albert Sickmann and René P. Zahedi
DOI: 10.1039/C5MB00024F, Opinion

Fatty acid biosynthesis revisited: structure elucidation and metabolic engineering
Joris Beld, D. John Lee and Michael D. Burkart
DOI: 10.1039/C4MB00443D, Review Article

Mechanism of action-based classification of antibiotics using high-content bacterial image analysis
Kelly C. Peach, Walter M. Bray, Dustin Winslow, Peter F. Linington and Roger G. Linington
DOI: 10.1039/C3MB70027E, Paper

Differential protein profile in sexed bovine semen: shotgun proteomics investigation
Michele De Canio, Alessio Soggiu, Cristian Piras, Luigi Bonizzi, Andrea Galli, Andrea Urbani and Paola Roncada
DOI: 10.1039/C3MB70306A, Paper

Connecting gene expression data from connectivity map and in silico target predictions for small molecule mechanism-of-action analysis
Aakash Chavan Ravindranath, Nolen Perualila-Tan, Adetayo Kasim, Georgios Drakakis, Sonia Liggi, Suzanne C. Brewerton, Daniel Mason, Michael J. Bodkin, David A. Evans, Aditya Bhagwat, Willem Talloen, Hinrich W. H. Göhlmann, QSTAR Consortium, Ziv Shkedy and Andreas Bender
DOI: 10.1039/C4MB00328D, Paper

NMR- and MS-based metabolomics: various organ responses following naphthalene intervention
Yee Soon Ling, Hao-Jan Liang, Meng-Hsuan Chung, Ming-Huan Lin and Ching-Yu Lin
DOI: 10.1039/C4MB00090K, Paper

Multifunctional polymeric micelles with folate-mediated cancer cell targeting and pH-triggered drug releasing properties for active intracellular drug delivery
Younsoo Bae, Woo-Dong Jang, Nobuhiro Nishiyama, Shigeto Fukushima and Kazunori Kataoka
DOI: 10.1039/B500266D, Paper

Development of novel assays for lignin degradation: comparative analysis of bacterial and fungal lignin degraders
Mark Ahmad, Charles R. Taylor, David Pink, Kerry Burton, Daniel Eastwood, Gary D. Bending and Timothy D. H. Bugg
DOI: 10.1039/B908966G, Paper

Evolutionary game theory: molecules as players
Katrin Bohl, Sabine Hummert, Sarah Werner, David Basanta, Andreas Deutsch, Stefan Schuster, Günter Theißen and Anja Schroeter
DOI: 10.1039/C3MB70601J, Review Article

Amidoligases with ATP-grasp, glutamine synthetase-like and acetyltransferase-like domains: synthesis of novel metabolites and peptide modifications of proteins
Lakshminarayan M. Iyer, Saraswathi Abhiman, A. Maxwell Burroughs and L. Aravind
DOI: 10.1039/B917682A, Paper

Evolutionary game theory: cells as players
Sabine Hummert, Katrin Bohl, David Basanta, Andreas Deutsch, Sarah Werner, Günter Theißen, Anja Schroeter and Stefan Schuster
DOI: 10.1039/C3MB70602H, Review Article

PLS/OPLS models in metabolomics: the impact of permutation of dataset rows on the K-fold cross-validation quality parameters
Mohamed N. Triba, Laurence Le Moyec, Roland Amathieu, Corentine Goossens, Nadia Bouchemal, Pierre Nahon, Douglas N. Rutledge and Philippe Savarin
DOI: 10.1039/C4MB00414K, Opinion

A red light-controlled synthetic gene expression switch for plant systems
Konrad Müller, David Siegel, Fernando Rodriguez Jahnke, Katrin Gerrer, Sabrina Wend, Eva L. Decker, Ralf Reski, Wilfried Weber and Matias D. Zurbriggen
DOI: 10.1039/C3MB70579J, Method

A genome-wide RNAi screen identifies novel targets of neratinib sensitivity leading to neratinib and paclitaxel combination drug treatments
Attila A. Seyhan, Usha Varadarajan, Sung Choe, Yan Liu, John McGraw, Matthew Woods, Stuart Murray, Amy Eckert, Wei Liu and Terence E. Ryan
DOI: 10.1039/C0MB00294A, Paper

In-depth comparative proteomic analysis of yeast proteome using iTRAQ and SWATH based MS
Trayambak Basak, Ajay Bhat, Dipankar Malakar, Manoj Pillai and Shantanu Sengupta
DOI: 10.1039/C5MB00234F, Paper

The distribution pattern of genetic variation in the transcript isoforms of the alternatively spliced protein-coding genes in the human genome
Ting Liu and Kui Lin
DOI: 10.1039/C5MB00132C, Paper

Metabolomics – the complementary field in systems biology: a review on obesity and type 2 diabetes
Mohamad Hafizi Abu Bakar, Mohamad Roji Sarmidi, Kian-Kai Cheng, Abid Ali Khan, Chua Lee Suan, Hasniza Zaman Huri and Harisun Yaakob
DOI: 10.1039/C5MB00158G, Review Article

Molecular insights of protein contour recognition with ligand pharmacophoric sites through combinatorial library design and MD simulation in validating HTLV-1 PR inhibitors
Chandrabose Selvaraj, Ankur Omer, Poonam Singh and Sanjeev Kumar Singh
DOI: 10.1039/C4MB00486H, Paper

Global signatures of protein and mRNA expression levels
Raquel de Sousa Abreu, Luiz O. Penalva, Edward M. Marcotte and Christine Vogel
DOI: 10.1039/B908315D, Review Article

Cysteine-mediated redox signalling in the mitochondria
D. W. Bak and E. Weerapana
DOI: 10.1039/C4MB00571F, Review Article

Structural analysis of intrinsically disordered proteins by small-angle X-ray scattering
Pau Bernadó and Dmitri I. Svergun
DOI: 10.1039/C1MB05275F, Review Article

Diminazene or berenil, a classic duplex minor groove binder, binds to G-quadruplexes with low nanomolar dissociation constants and the amidine groups are also critical for G-quadruplex binding
Jie Zhou, Vu Le, Dimpy Kalia, Shizuka Nakayama, Clinton Mikek, Edwin A. Lewis and Herman O. Sintim
DOI: 10.1039/C4MB00359D, Paper

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