In this review Ana Cristina Andreazza looks at the use of redox-proteomics and epigenomics to improve our understanding of the pathophysiology of psychiatric illnesses such as biopolar disorder and schizophrenia. Oxidative stress and mitochondrial dysfunction have recently been implicated as common features in major psychiatric disorders, but only through a combination of techniques can we begin to understand the nature of oxidative modification, its potential to change protein–protein interactions and induce epigenetic modification says Andreazza. Understanding the molecular targets for oxidation should hopefully lead to the development of new drug treatments or disease biomarkers.
The review covers:
1. Oxidative stress and redox balance
2. The link between DNA oxidation and DNA methylation
3. Psychiatry and oxidative stress: what do we know so far?
4. Developing biomarkers to assist in predicting the course of psychiatric illnesses
Combining redox-proteomics and epigenomics to explain the involvement of oxidative stress in psychiatric disorders
Ana Cristina Andreazza