Wheat lectin shows potential as targeted carrier for anticancer drugs

A lectin from wheat, wheat germ agglutinin (WGA),  has the potential to help target anticancer agents to tumour cells Vanya Bogoeva and colleagues from the Bulgarian Academy of Sciences and Sophia University have found.

One of the issues with current anticancer drugs, such as cis-platin, is that they are non-specific to tumour tissue, and so can cause severe side effects by destroying normal cells. WGA can recognise cancer cells, and is taken up by them – it also has a high affinity for four metal-based anticancer agents: cisplatin, a Pt porphyrin and two gold porphyrins and therefore may have potential as a drug delivery molecule for metal-based anticancer drugs.

As with all our HOT articles, this one is free to access for 4 weeks following a simple registration:

Characterization of metalloanticancer capacity of an agglutinin from wheat
Vanya P. Bogoeva,  Lidiya P. Petrova,  Ivan B. Ivanov,  Hristina N. Kulina and Ivan Ch. Buchvarov
DOI: 10.1039/C2MB25186H

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Leave a Reply

*