The outside front cover of issue 8 features work from Mark Ragan and co-workers at the University of Queensland, Australia. In their paper, they use full-length human cDNAs to interrogate the protein-coding transcriptional output of genes, showing the variation in the inclusion of protein interaction domains. This data was then mapped to protein interaction data, to show the variation in network connectivity that was likely.
Rewiring the dynamic interactome
Melissa J. Davis, Chang Jin Shin, Ning Jing and Mark A. Ragan
The inside front cover features work from Eric Maréchal and colleagues in France. In the review article, Galvestine-1 is discussed as a probe to study the lipid homeostasis system at the whole cell level and the review highlights connections between monogalactosyldiacylglycerol synthesis and Arabidopsis flower development.
Galvestine-1, a novel chemical probe for the study of the glycerolipid homeostasis system in plant cells
Laurence Boudière, Cyrille Y. Botté, Nadia Saidani, Mathieu Lajoie, Jessica Marion, Laurent Bréhélin, Yoshiki Yamaryo-Botté, Béatrice Satiat-Jeunemaître, Christelle Breton, Agnès Girard-Egrot, Olivier Bastien, Juliette Jouhet, Denis Falconet, Maryse A. Block and Eric Maréchal
As with all our cover articles, both of these are free to access (following a simple registration) for 6 weeks.
Also included in the issue are a method for detecting protein–protein interactions in vivo, and papers focusing on understanding the molecular basis of MK2–p38α signaling complex assembly and a large scale phosphoproteome analysis of LNCaP human prostate cancer cells.
Read the rest of the issue here.