On the inside front cover of Issue 19 an article from Sebastian Meier and Jens Ø. Duus from the Carlsberg Laboratory, Denmark is highlighted. They have used DNP-NMR to study entire metabolic pathways in living yeast cells, with real time visualisation. Glucose and fructose signals were enhanced by a methodology called DNP and injected into cell suspensions, circumventing the need for chemically introduced reporter groups or metabolite extraction, and allowing studies of cellular metabolism in a more realistic, undisturbed environment.
This hot cover article is free to download for the next 6 weeks – so why not take a look?
Metabolic pathway visualization in living yeast by DNP-NMR
Sebastian Meier, Magnus Karlsson, Pernille R. Jensen, Mathilde H. Lerche and Jens Ø. Duus
Mol. BioSyst., 2011, 7, 2834-2836