In this review article Kimberly Beatty, University of California, gives an overview of the various methods available to understand cellular proteomes through chemical tagging and subsequent visualisation.
The review covers the tagging and identification of a subset of a proteome, imaging specific subsets, dual-labelling subsets and live cell imaging – concluding with a call for chemical biologists, chemists and biologists to work together to develop more robust, interdisciplinary methods that will increase our understanding of these enormously complex biological systems.
We’ve made this HOT article free to access for four weeks – so download it today and maybe you’ll get some ideas!
Chemical strategies for tagging and imaging the proteome
Kimberly E. Beatty
Mol. BioSyst., 2011, Advance Article