Archive for December, 2010

DNA vaccine induced autoimmune disease

Safety concerns over the use of a DNA vaccine have been raised by Chinese scientists after they observed that it induced autoimmune disease in mice.

DNA vaccines are genetically engineered parts of virus DNA that are injected into the body to boost the immune system’s response to viral, bacterial and parasitic pathogens. Cells in the body convert the DNA into proteins that are recognised as foreign by the immune system, which triggers a response. In conventional vaccines, weakened or killed forms of the virus are injected. DNA vaccines eliminate the risk of infection associated with conventional vaccines, are extremely stable and can provide long-lived immune responses.

However, Shuhan Sun and his team from the Second Military Medical University, Shanghai, were testing mice for reactions to a DNA vaccine called pcDNA3-b1. They noticed that the mice developed symptoms of vitiligo – a skin pigmentation disorder where patches of skin lose colour – within six weeks of a third immunisation.

Mice developed vitiligo symptoms within six weeks of a third immunisation

Click here to read the full story

Link to journal article
Down-regulation of Prdx6 contributes to DNA vaccine induced vitiligo in mice
Qi Zhou, Fang Wang, Yi Zhang, Fu Yang, Yue Wang and Shuhan Sun, Mol. BioSyst., 2011
DOI: 10.1039/c0mb00181c

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Top ten most accessed articles in October

This month sees the following articles in Molecular BioSystems that are in the top ten most accessed:-

Molecular probes for the in vivo imaging of cancer¬
Raphael Alford, Mikako Ogawa, Peter L. Choyke and Hisataka Kobayashi¬
Mol. BioSyst., 2009, 5, 1279-1291, DOI: 10.1039/B911307J, Review¬†¬

Genome-wide survey of microRNA-transcription factor feed-forward regulatory circuits in human¬
Angela Re, Davide Cor√°, Daniela Taverna and Michele Caselle¬
Mol. BioSyst., 2009, 5, 854-867, DOI: 10.1039/B900177H, Paper¬†¬

Small-molecule modulators of the Sonic Hedgehog signaling pathway¬
Benjamin Z. Stanton and Lee F. Peng¬
Mol. BioSyst., 2009, 6, 44-54, DOI: 10.1039/B910196A, Review¬†¬

Combining nanotechnology with current biomedical knowledge for the vascular imaging and treatment of atherosclerosis¬
M. Slevin, L. Badimon, M. Grau-Olivares, M. Ramis, J. Sendra, M. Morrison and J. Krupinski¬
Mol. BioSyst., 2010, 6, 444-450, DOI: 10.1039/B916175A, Review¬†¬

Mirror image phage display – a method to generate D-peptide ligands for use in diagnostic or therapeutical applications¬
Susanne Aileen Funke and Dieter Willbold¬
Mol. BioSyst., 2009, 5, 783-786, DOI: 10.1039/B904138A, Review¬†¬

Scoring overlapping and adjacent signals from genome-wide ChIP and DamID assays¬
Audrey Qiuyan Fu and Boris Adryan¬
Mol. BioSyst., 2009, 5, 1429-1438, DOI: 10.1039/B906880E, Review¬†¬

Overcoming glucose repression in mixed sugar fermentation by co-expressing a cellobiose transporter and a ő≤-glucosidase in Saccharomyces cerevisiae¬
Sijin Li, Jing Du, Jie Sun, Jonathan M. Galazka, N. Louise Glass, Jamie H. D. Cate, Xiaomin Yang and Huimin Zhao¬
Mol. BioSyst., 2010, 6, 2129-2132, DOI: 10.1039/C0MB00063A, Communication¬†¬

Multicolor single-molecule FRET to explore protein folding and binding¬
Yann Gambin and Ashok A. Deniz¬
Mol. BioSyst., 2010, 6, 1540-1547, DOI: 10.1039/C003024D, Review¬†¬

Protein trans-splicing and its use in structural biology: opportunities and limitations¬
Gerrit Volkmann and Hideo Iwa√Į¬
Mol. BioSyst., 2010, 6, 2110-2121, DOI: 10.1039/C0MB00034E, Review¬†¬

Global signatures of protein and mRNA expression levels¬
Raquel de Sousa Abreu, Luiz O. Penalva, Edward M. Marcotte and Christine Vogel¬
Mol. BioSyst., 2009, 5, 1512-1526, DOI: 10.1039/B908315D, Review¬†¬

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to Molecular BioSystems? Then why not submit to us today or alternatively email us your suggestions.  

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