Archive for December, 2010

DNA vaccine induced autoimmune disease

Safety concerns over the use of a DNA vaccine have been raised by Chinese scientists after they observed that it induced autoimmune disease in mice.

DNA vaccines are genetically engineered parts of virus DNA that are injected into the body to boost the immune system’s response to viral, bacterial and parasitic pathogens. Cells in the body convert the DNA into proteins that are recognised as foreign by the immune system, which triggers a response. In conventional vaccines, weakened or killed forms of the virus are injected. DNA vaccines eliminate the risk of infection associated with conventional vaccines, are extremely stable and can provide long-lived immune responses.

However, Shuhan Sun and his team from the Second Military Medical University, Shanghai, were testing mice for reactions to a DNA vaccine called pcDNA3-b1. They noticed that the mice developed symptoms of vitiligo – a skin pigmentation disorder where patches of skin lose colour – within six weeks of a third immunisation.

Mice developed vitiligo symptoms within six weeks of a third immunisation

Click here to read the full story

Link to journal article
Down-regulation of Prdx6 contributes to DNA vaccine induced vitiligo in mice
Qi Zhou, Fang Wang, Yi Zhang, Fu Yang, Yue Wang and Shuhan Sun, Mol. BioSyst., 2011
DOI: 10.1039/c0mb00181c

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Top ten most accessed articles in October

This month sees the following articles in Molecular BioSystems that are in the top ten most accessed:-

Molecular probes for the in vivo imaging of cancer 
Raphael Alford, Mikako Ogawa, Peter L. Choyke and Hisataka Kobayashi 
Mol. BioSyst., 2009, 5, 1279-1291, DOI: 10.1039/B911307J, Review  

Genome-wide survey of microRNA-transcription factor feed-forward regulatory circuits in human 
Angela Re, Davide Corá, Daniela Taverna and Michele Caselle 
Mol. BioSyst., 2009, 5, 854-867, DOI: 10.1039/B900177H, Paper  

Small-molecule modulators of the Sonic Hedgehog signaling pathway 
Benjamin Z. Stanton and Lee F. Peng 
Mol. BioSyst., 2009, 6, 44-54, DOI: 10.1039/B910196A, Review  

Combining nanotechnology with current biomedical knowledge for the vascular imaging and treatment of atherosclerosis 
M. Slevin, L. Badimon, M. Grau-Olivares, M. Ramis, J. Sendra, M. Morrison and J. Krupinski 
Mol. BioSyst., 2010, 6, 444-450, DOI: 10.1039/B916175A, Review  

Mirror image phage display – a method to generate D-peptide ligands for use in diagnostic or therapeutical applications 
Susanne Aileen Funke and Dieter Willbold 
Mol. BioSyst., 2009, 5, 783-786, DOI: 10.1039/B904138A, Review  

Scoring overlapping and adjacent signals from genome-wide ChIP and DamID assays 
Audrey Qiuyan Fu and Boris Adryan 
Mol. BioSyst., 2009, 5, 1429-1438, DOI: 10.1039/B906880E, Review  

Overcoming glucose repression in mixed sugar fermentation by co-expressing a cellobiose transporter and a β-glucosidase in Saccharomyces cerevisiae 
Sijin Li, Jing Du, Jie Sun, Jonathan M. Galazka, N. Louise Glass, Jamie H. D. Cate, Xiaomin Yang and Huimin Zhao 
Mol. BioSyst., 2010, 6, 2129-2132, DOI: 10.1039/C0MB00063A, Communication  

Multicolor single-molecule FRET to explore protein folding and binding 
Yann Gambin and Ashok A. Deniz 
Mol. BioSyst., 2010, 6, 1540-1547, DOI: 10.1039/C003024D, Review  

Protein trans-splicing and its use in structural biology: opportunities and limitations 
Gerrit Volkmann and Hideo Iwaï 
Mol. BioSyst., 2010, 6, 2110-2121, DOI: 10.1039/C0MB00034E, Review  

Global signatures of protein and mRNA expression levels 
Raquel de Sousa Abreu, Luiz O. Penalva, Edward M. Marcotte and Christine Vogel 
Mol. BioSyst., 2009, 5, 1512-1526, DOI: 10.1039/B908315D, Review  

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to Molecular BioSystems? Then why not submit to us today or alternatively email us your suggestions.  

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