Archive for the ‘Ongoing Thematic Collections’ Category

Wearable-Implantable Sensors Thematic Collection-open for submissions

We are very pleased to announce a new Thematic Collection on Wearable and Implantable sensors!

Cover Image from 10.1039/C7LC00914C

Cover image for 10.1039/C7LC00914C

A ‘super-team’ of Lab on a Chip authors (10.1039/c7lc00914c) recently wrote, “Wearable sensing technology has recently and rapidly moved from largely a vision of science fiction to a wide array of established consumer and medical products. This explosion of wearable sensors can be attributed to several factors, such as affordability and ergonomics provided by advances in miniaturized electronics, the proliferation of smart-phones and connected devices, a growing consumer desire for health awareness, and the unmet need for doctors to continuously obtain medical quality data from their patients.”

Following this, we at Lab on a Chip have been inspired to create an Editors’ Choice collection highlighting some of our favourite recent papers in the area and to also seek more contributions in this area. The collection will feature a series of papers that address aspects of the issues involved in creating wearable or implantable sensors and their applications for diagnostics, medicine and therapeutics, health awareness and other novel applications.

Below is a selection of content highlights featured in the collection so far. In addition, all papers are free to read until 31st October 2019*.

Wearable sensors: modalities, challenges, and prospects

J. Heikenfeld, A. Jajack, J. Rogers, P. Gutruf, L. Tian, T. Pan, R. Li, M. Khine, J. Kim, J. Wang and J. Kim

 

Flexible plastic, paper and textile lab-on-a chip platforms for electrochemical biosensing

Anastasios Economou, Christos Kokkinos and Mamas Prodromidis

 

Microfluidic neural probes: in vivo tools for advancing neuroscience

Joo Yong Sim, Jae-Woong Jeong, et al.

 

Passive sweat collection and colorimetric analysis of biomarkers relevant to kidney disorders using a soft microfluidic system

Yi Zhang, John A. Rogers, et al.

 

Complete validation of a continuous and blood-correlated sweat biosensing device with integrated sweat stimulation

A Hauke, J. Heikenfeld, et al.

 

Interested in submitting to the collection?

We are interested in contributions of review and research articles in this area and this collection is now open for submissions into 2020. If you’re interested in contributing to this collection, please contact the Editorial Office.

*Access is free through an RSC account (free to register)

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Organ-on-a-Chip systems-translating concept into practice Thematic Collection

We are pleased to announce a new Thematic Collection on Organ-on-a-Chip systems, translating concept into practice!

The first collection of papers on “Organ-body-and disease-on-a-Chip” collection has proved to be popular with the community. The collection has given this emerging field an identity and an effective venue for others to learn of the breadth, depth, and importance of this emerging area. We are delighted to announce that Michael Shuler (Cornell University, USA) will be acting as Thought Leader this follow-up collection.

We believe that a second collection highlighting efforts to translate this concept into practice would be valuable. While proof-of-concept papers for potential devices remains important, there has been significant progress in the last two years towards addressing the practical issues of translating these concepts into workable systems that will be adopted by industry and approved by regulators. While pharmaceuticals remain the primary target, it is clear that these devices will play important roles in the cosmetic, food, and chemical industries.

For regulatory approval and industrial adoption these devices need to be simple (easy to run by a technician), largely self-contained, low cost, reliable, incorporate advanced analytical techniques, and have efficient software to convert measurements into predictions of human response. Some of the initial proof-of-concept devices are too complicated and hence costly to be implemented industrially.  For an academic paper a lab can afford to have a high failure rate of systems as long as sufficient systems function to provide a robust data set.  For an industrial setting a high success rate will be necessary for adoption.  Automation of devices and efficient data collection and interpretation will be necessary for systems to have a broad impact and reduce labour costs.  Although much of the industrial data are proprietary, it should be possible to take historical cases where a drug candidate was approved and then withdrawn from the market due to toxicity and determine if the failure of the drug could have been anticipated from studies with a microphysiological (MPS) system.  Such examples could provide a compelling rationale for inclusion of MPS systems particularly in the later stages of the preclinical drug development process.

A series of papers that address aspects of the issues involved in moving from “proof-of-principle” devices to systems that can be routinely incorporated into testing of drugs, cosmetics, food ingredients, and chemicals would be valuable to the development of the field of microphysiological systems. We seek contributions that will help us fulfill this goal.

Lab on a Chip publishes the best work on significant and original work related to minia-turisation, at the micro- and nano-scale, of interest to a multidisciplinary readership. The journal seeks to publish work at the interface between physical technological advancements and high impact applications that are of direct interest to a broad audience.

Extraordinarily novel organ-on-a-chip systems that demonstrate unique new functions are also welcome.

Interested in submitting to the collection? 

We welcome submissions of original research articles and reviews to this collection and the collection is open for submissions.

Articles included in the collection will be published as they are accepted and collected into an online collection. They will receive extensive promotion throughout the submission period and as a complete collection.

If you are interested in submitting to the series, please get in touch with the Lab on a Chip Editorial Office at loc-rsc@rsc.org.

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Personalised Medicine: Liquid Biopsy

We are delighted to announce our latest Thematic Collection in Lab on a Chip – Personalised Medicine: Liquid Biopsy!

This collection is being lead by Thought Leaders Stefanie Jeffrey and Mehmet Toner.

Stefanie Jeffrey, MD, is the John and Marva Warnock Professor and Chief of Surgical Oncology Research in the Department of Surgery at Stanford University School of Medicine. Her lab focuses on technology development and applications related to liquid biopsy (CTCs, ctDNA, extracellular vesicles), droplet-based microfluidic platforms, and preclinical models for testing new cancer therapies.

Mehmet Toner, PhD, is a member of the faculty at the Center for Engineering in Medicine at Massachusetts General Hospital. Dr. Toner is motivated by multi-disciplinary problems at the interface of engineering and life sciences. In the fields of microfluidics/micro-engineering/cancer he is working on microfluidics in biology and medicine including microfluidic blood processing, developing a microchip to help sort rare cells and integration of living cells and micro-engineered tissue units into micro-devices.

Liquid Biopsy, coined by Pantel and Alix-Panabières in 2010, originally referred to real-time analyses of CTCs in cancer. However, that term has since expanded to encompass the analyses of many other disease-related substances found in blood and other body fluids. Our goal is to highlight the new advances in this growing field with an emphasis on the interface between the technological advancements and high impact applications of liquid biopsy technologies. These would include manuscripts related to components that can be captured or characterized from blood such as circulating tumour cells, circulating nucleic acids and circulating extracellular vesicles.

Interested in submitting to the collection?

If you are interested in submitting to the personalised medicine: liquid biopsy collection, please contact the Lab on a Chip Editorial Office at loc-rsc@rsc.org  and provide a title and abstract of your proposed submission.

Articles will be published as they are accepted and collated into an online Thematic Collection, which will receive extensive promotion. Read the collection so far – http://rsc.li/liquid-biopsy 

Submissions for this collection are open from 1st September 2017 to 31st October 2018

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Droplet-Based Single-Cell Sequencing

We are pleased to announce the latest Thematic Collection in Lab on a ChipDroplet-Based Single-Cell Sequencing!

We are delighted that Lab on a Chip Advisory Board member David A Weitz (Harvard University, USA) is Thought Leader of this collection!

The field of droplet-based single-cell sequencing field has made increasing advances in recent years. Large numbers of studies are underway to collect and explore the new information that is now accessible with single-cell RNA-seq. Improvements to microfluidics are advancing rapidly and extensions to other sequencing methods are also being developed, enabling investigations to probe information beyond mRNA alone. This has rapidly become a burgeoning field, where microfluidic techniques are essential and where droplet-based microfluidics has enabled a major advance.

For more context, please read the editorials “Perspective on droplet-based-single cell sequencing” by David Weitz and “InDrops and Drop-seq technologies for single-cell sequencing” by Allon Klein and Evan Macosko.

The goal of this collection is to highlight the new advances in this growing field, with an emphasis on the interface between the technological advancements and high impact applications of droplet-based single-cell sequencing.

Read articles included in the collection so far at rsc.li/drop-sc-seq

Interested in submitting to the collection?

If you are interested in contributing to the droplet-based single-cell sequencing collection, please get in touch with the Lab on a Chip Editorial Office at loc-rsc@rsc.org and provide a title and abstract of your proposed submission.

Articles will be published as they are accepted and collated into an online Thematic Collection, which will receive extensive promotion.

Submissions for this collection are open from 15th July 2017 to 30th April 2018 

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Organ-, Body- and Disease-on-a-Chip Thematic Collection

We are pleased to announce Lab on a Chip‘s first Thematic Collection in 2017, Organ-, Body- and Disease-on-a-Chip!

We are delighted to announce that Michael Shuler (Cornell University, USA) will be acting as Thought Leader for this collection. His research focuses on “Body-on-a-Chip” devices applied to evaluate different treatments for cancer, such as multi-drug resistant cancer. Read Michael Shuler’s recent Editorial for more information.

An emerging area of interest for drug development over the last 13 years has been constructing human biomimetic systems by combining the techniques of microfabrication and tissue engineering. In this collection, we define an “Organ-on-a-Chip” as a physical microscale model (typically an order of 10−6 to 10−4 of actual size) of a particular human organ.

The questions we aim to address in this collection are whether these emerging technologies will improve both drug development and the regulation of human exposure to chemicals. What technical challenges remain? What will be the most effective way to utilize this emerging technology? Can this technology lead to cost effective, measurable improvements in human health? Our goal is to highlight the new advances in this growing field with an emphasis on the interface between the technological advancements and high impact applications of organ-, body- and disease-on-a-chip technologies.

Interested in submitting to the collection? 

We have recently launched a second collection highlighting efforts to translate this concept into practice. A series of papers that address aspects of the issues involved in moving from “proof-of-principle” devices to systems that can be routinely incorporated into testing of drugs, cosmetics, food ingredients, and chemicals would be valuable to the development of the field of microphysiological systems. We seek contributions that will help us fulfill this goal. More information can be found on the updated blog.  

We welcome submissions of original research articles and reviews to this collection and the collection is open for submissions. 

If you are interested in submitting to the series, please get in touch with the Lab on a Chip Editorial Office at loc-rsc@rsc.org.

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Emerging Investigator Series for Lab on a Chip

Starting in 2017, Lab on a Chip will be running an Emerging Investigator Series to showcase some of the best work in the field of miniaturisation at the micro- and nano-scale, being conducted by early-career researchers. The Series will ongoing, with articles being published once they are accepted and collated online.

There are many benefits for Emerging Investigators contributing to the series, with articles being featured in an online collection and receiving extensive promotion. This includes a special mention in journal contents alerts and an interview on the journal blog. Published articles will also be made free to access for a limited period. Furthermore, the continuous format is designed to allow more flexibility for contributors to participate in the venture without the restriction of submission deadlines.

We’ve received great feedback from previous Emerging Investigators, including this quote: “Being part of the Emerging Investigators issue was an honor and helpful to my career.  Thanks again for including me” (2012 Emerging Investigator)

Read the articles included in the collection so far at – rsc.li/loc-emerging-investigator

To represent the whole of the Lab on a Chip community, the Series will have three international Series Editors with a broad range of expertise: Editorial Board members, Dino Di Carlo (UCLA, USA), Yoon-Kyoung Cho (UNIST, South Korea) and Piotr Garstecki (IPC PAC, Poland)

 

To be eligible for the new Emerging Investigator Series you will need to have completed your PhD (or equivalent degree) within the last 10 years, although appropriate consideration will be given to those who have taken a career break or followed a different study path, and have an independent career. If you are interested in contributing to the Series please contact the Editorial Office (loc-rsc@rsc.org) and provide the following information:

  • Your up-to-date CV (no longer than 2 pages), which should include a summary of education and career, a list of relevant publications, any notable awards, honours or professional activities in the field, and a website URL if relevant;
  • A title and abstract of the research article intended to be submitted to the Series, including a tentative submission date. Please note that articles submitted to the journal for the Series will undergo the usual peer review process.

Keep up to date with the latest papers added to this Series on our twitter feed (@LabonaChip) with the hashtags #EmergingInvestigators #LabonaChip

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