Archive for the ‘News’ Category

Organ–organ interactions could compound nanoparticle damage

A microfluidic device that recreates interactions between the gastrointestinal (GI) tract and the liver to give a more realistic assessment of nanoparticle toxicity has detected liver tissue injury at lower nanoparticle concentrations than expected following experiments with liver tissue only.

Many studies look at the beneficial medical effects of nanoparticles, however, Mandy Esch explains that her work in Michael Shuler’s lab at Cornell University is checking for adverse effects.

To read the full article, please visit Chemistry World.

Body-on-a-chip simulation with gastrointestinal tract and liver tissues suggests that ingested nanoparticles have the potential to cause liver injury
Mandy B. Esch, Gretchen J. Mahler, Tracy Stokol and Michael L. Shuler
Lab Chip, 2014, Advance Article
DOI: 10.1039/C4LC00371C, Paper

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The winning challenge is antibiotics!

Antibiotic Resistance

http://www.longitudeprize.org/

Over the past month, members of the public have been voting for six  challenges to win the Longitude Prize and last week it was announced that antibiotics was the winning category.

The development of antibiotics has been vital to our survival, adding 20 years to each persons life on average – but antimicrobial resistance is threatening to cause antibiotics to become ineffective in the future. Along with the development of new antibiotics, diagnostics are crucial in ensuring that patients receive appropriate treatment; to help us to monitor infection and to conserve the therapies we have by only administrating to those that really need them.

The challenge for Longitude Prize 2014 will be set to create a cheap, accurate, rapid and easy-to-use point of care test kit to identify bacterial infections.

We are working with a number of learned societies to develop community initiatives to bring researchers from different disciplines together to stimulate research in the infections disease area. Supporting the Longitude Prize challenge, we have made the following relevant Lab on a Chip articles free* to access for a limited time, so click on the links below and download them today!

Time Lapse Investigation of Antibiotic Susceptibility using a Microfluidic Linear Gradient 3D Culture Device
Zining Hou,   Yu An,   Karin Hjort,   Klas Hjort,  Linus Sandegren and   Zhigang WU
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00451E

Antimicrobial susceptibility assays in paper-based portable culture devices
Frédérique Deiss, Maribel E. Funes-Huacca, Jasmin Bal, Katrina F. Tjhung and   Ratmir Derda

Lab Chip, 2014,14, 167-171
DOI: 10.1039/C3LC50887K


* Access is free through a registered RSC account – click here to register
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DVD diagnostics

A pregnancy test based on standard DVD technology has the potential to be turned into a diagnostic platform that screens for abnormal pregnancies or even testicular cancer.

The DVD assay design and signal reading principle

We all hate waiting for tests results, especially when it comes to medical tests where the uncertainty of not knowing what’s wrong can be a real worry. As a result, the development of diagnostic tests that can be performed wherever the patient is, whether that is at home, in a doctor’s surgery or in a medical centre in the developing world, obtaining almost instantaneous results is a current hot topic. Over the past few years, a wide range of point-of-care diagnostic platforms have been developed and the field holds tremendous potential, perhaps one day eliminating the need for laboratory-based diagnostic tests altogether.

To read the full article please visit Chemistry World.

DVD technology-based molecular diagnosis platform: quantitative pregnancy test on a disc
Xiaochun Li, Samuel Weng, Bixia Ge, Zhihui Yao and Hua-Zhong Yu  
Lab Chip, 2014, Advance Article
DOI: 10.1039/C3LC51411K, Paper

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Dicty World Race 2014 – which cells will make it to the finish line first?

What?

The Dicty World Race is a cell engineering challenge – competitors must apply their knowledge of chemotaxis to engineer the ultimate chemotaxing cell line. The test is between Dictyostelium, HL60 cells and human neutrophils.

Cells will navigate a complex microfluidic maze to reach a pool of chemoattractant at the finish line. As the race goes on, chemoattractant will diffuse through the microfluidic device, creating a spatial gradient to guide cells along the shortest path.

When?

The date for the 2014 Dicty Race is set for Friday May 16

Why?

To show off your molecular skills!

If you need more encouragement to take part, the winning team will win $5,000 and 15 minutes of fame at the Annual Dicty Conference.

More info?

Visit the website for more details: https://sites.google.com/site/dictyworldrace2014/

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Tiny islands set sperm spinning

A platform for simultaneously screening thousands of sperm cells could lead to more efficient identification of high performing sperm for fertility treatments.

Protein islands trap individual sperm cells for motility analysis

 Assisted reproductive technologies have revolutionised the fertility world, however, sperm must be carefully picked on the basis of specific characteristics, including motility, to increase the chance of a successful pregnancy. However, more than half of the sperm selected for intra-cytoplasmic sperm injection (ICSI) using current procedures are damaged.

To read the full article, please go to Chemistry World.

Make it Spin: Individual Trapping of Sperm for Analysis and Recovery Using Micro-Contact Printing
Jean-Philippe Frimat, Mathijs Bronkhorst, Bjorn de Wagenaar, Johan Bomer, Ferdi van der Heijden, Albert van den Berg and Loes Segerink  
Lab Chip, 2014, Accepted Manuscript
DOI: 10.1039/C4LC00050A, Paper

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Emerging Technologies Competition 2014

The Royal Society of Chemistry is holding a competition to identify the latest technologies in chemical sciences which have significant potential impact on the UK economy.

The winner will receive one to one mentoring from renowned multinational companies and up to a £10,000 cash prize.

If you have an emerging technology that could be the next big chemical science revolution, submit your application by 1 March 2014!

Follow the link to find out more: http://rsc.li/LGCAwM


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Art In Science Award – the contenders

Every year, Lab on a Chip sponsors the Art in Science award, titled: “Under the Looking Glass: Art from the World of Small Science”. This award, presented at the annual microfluidics conference MicroTas, aims to draw attention to the aesthetic value in scientific illustrations while still conveying scientific merit.

In 2013, the submissions were as fantastic as ever, so we must say a big well done to all of our contributors!

Have a look below at 2013’s winner, and other highly commended pieces…


The Winner: “Artificial Life” by Ye Wang, Eindhoven University of Technology.


An SEM image of artificial cilia (microhairs) made with Polydimethylsiloxane and magnetic nanoparticles using a glass mold made by femtolaser modification and hydrofluoric acid etching.


Highly Commended: “Trapping Trapping” by Satoru Ito, Nagoya University.

Fabricated ZnO nanowire (100 nm in diameter and 2-3 micrometer in length) trapping 100 nm beads by electrostatic interaction.


Highly Commended: “Nanoforest” by Sakon Rahong, Osaka University.

A colorised SEM micrograph showing Christmas-tree nano wires prepared by Vapour Liquid Solid (VLS) growth embedded in microchannel for fast DNA separation.


Highly Commended: “Van Gogh’s Wall Paper” by You-Ren Hsu, Institute of NanoEngineering and MicroSystems, NTHU.

Salt crystallization on a gold coated photonic crystal substrate. The salt crystallization changed the index of refraction on the surface, making the color tone.

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MicroTas abstracts are now online!

Lab on a Chip presents uTAS Abstracts 2003 to Present:

The page link below gives the lab on a chip/microfluidics/uTAS communities FREE ACCESS to both current and archived content submitted to the uTAS conferences in the form of extended abstracts. It is hoped that this service will support workers in finding essential references and hence increase knowledge of past work in the field and assist with current and future research.

This archive includes abstracts presented at uTAS meetings from 2003 to present and essentially provides easy web access to the abstract discs supplied at the uTAS meetings.


CLICK HERE for abstracts! http://rsc.li/1eYWXQs

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Device runs on finger power

Researchers in the US have demonstrated that mechanical energy from a human hand can power a microfluidic device.

The behaviour of liquids on a charged dielectric surface can be controlled by passing a current through that surface, known as the electrowetting on dielectric phenomenon (EWOD). In digital microfluidic devices, individual droplets containing samples or reagents are manipulated, allowing the controlled movement and mixing of reagents in different droplets. However, the need for a bulky external high-voltage power supply currently limits the potential application in biomedical devices and optics.

Movement creates piezoelectric potentials for manipulating droplets in the microfluidic system

 To read the full article please visit Chemistry World.

EWOD (Electrowetting on Dielectric) Digital Microfluidics Powered by Finger Actuation
Cheng Peng, Zhongning Zhang, Chang-Jin Kim and Y. Sungtaek Ju  
Lab Chip, 2013, Accepted Manuscript
DOI: 10.1039/C3LC51223A, Paper

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Seasons Greetings from Lab on a Chip!

The holidays are nearly here!!

We know everyone’s been working hard to finish off semesters and write up those papers. Here in Cambridge we’ve been working hard too, planning for the New Year and wrapping up 2013.

To spread the holiday cheer, we’ve chosen three highly accessed papers and made them *FREE TO ACCESS* for the next four weeks. Enjoy!

Merry Christmas from the LOC team!




Paper: Albumin testing in uring using a smartphone, by Aydogan Ozcan, UCLA

Critical Review: Paper-based microfluidic point-of-care diagnostic devices, by Ali Kemal Yetisen, Cambridge

Paper: Cholesterol testing on a smartphone, by David Erickson, Cornell




Access is free through a registered RSC account – click here to register

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