Author Archive

Droplet-Based Single-Cell Sequencing

We are pleased to announce the latest Thematic Collection in Lab on a ChipDroplet-Based Single-Cell Sequencing!

We are delighted that Lab on a Chip Advisory Board member David A Weitz (Harvard University, USA) is Thought Leader of this collection!

The field of droplet-based single-cell sequencing field has made increasing advances in recent years. Large numbers of studies are underway to collect and explore the new information that is now accessible with single-cell RNA-seq. Improvements to microfluidics are advancing rapidly and extensions to other sequencing methods are also being developed, enabling investigations to probe information beyond mRNA alone. This has rapidly become a burgeoning field, where microfluidic techniques are essential and where droplet-based microfluidics has enabled a major advance.

For more context, please read the editorials “Perspective on droplet-based-single cell sequencing” by David Weitz and “InDrops and Drop-seq technologies for single-cell sequencing” by Allon Klein and Evan Macosko.

The goal of this collection is to highlight the new advances in this growing field, with an emphasis on the interface between the technological advancements and high impact applications of droplet-based single-cell sequencing.

Interested in submitting to the collection?

If you are interested in contributing to the droplet-based single-cell sequencing collection, please get in touch with the Lab on a Chip Editorial Office at loc-rsc@rsc.org and provide a title and abstract of your proposed submission.

Articles will be published as they are accepted and collated into an online Thematic Collection, which will receive extensive promotion.

Submissions for this collection are open from 15th July 2017 to 30th April 2018 

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Meet our new Advisory Board members!

Oscar Ces is a Professor in Chemistry at Imperial College London, UK. He is a leading specialist in soft condensed matter, chemical biology, microfluidics, artificial cells, single cell analysis and lipid membrane mechanics.
 Daniel Irimia is an Associate Professor of Surgery and Deputy Director of the BioMEMS Resource Center at the Center for Engineering in Medicine (CEM) at Massachusetts General Hospital, USA. He is an internationally recognized expert in bioengineered microsystems for cellular chemotaxis and other functional assays.
  Sunghoon Kwon is an Associate Professor in the Department of Electrical and Computer Engineering at Seoul National University, South Korea. His research interests include optofluidic nanofabrication, BioMEMS, bioengineering, biophotonics, ultrasmall laser projection display, and human computer interfaces.
   Weihua Li is a Senior Professor for the School of Mechanical, Materials and Mechatronic Engineering at Wollongong University, Australia. His research focuses on magnetorheological (MR) fluids and MR elastomers and their applications, dynamics and vibration control, microfluidics and nanofluidics and lab on a chip.
  Chwee Teck Lim is a NUSS professor in the Department of Biomedical Engineering at the National University of Singapore. His research focuses on human disease biomechanics & mechanobiology, microfluidic technologies for disease detection, diagnosis and therapy and 2D materials for biomedical applications.
Nam-Trung Nguyen is Director of the Queensland Micro- and Nanotechnology Centre at Griffith University, Australia. His research is focused on microfluidics, nanofluidics, micro/nanomachining technologies, micro/nanoscale science, and instrumentation for biomedical applications.
David Sinton is a Professor and Canada Research Chair in Microfluidics and Energy at the University of Toronto. His research involves the study and application of small scale fluid mechanics (microfluidics, nanofluidics, and optofluidics) for use in energy systems and analysis.
  Hongkai Wu is Associate Professor for the Microfluidics Group at the Hong Kong University of Science and Technology. His research focuses on the interdisciplinary frontiers of microfluidics, bioanalytical science and materials chemistry.
  Chaoyong James Yang is a Professor in Chemical Biology at Xaimen University, China. His current research centers on microfluidics, molecular recognitions, DNA self-assembly and early diagnosis of cancer.
  Roland Zengerle is the Head of Laboratory for MEMS Applications and co-director of Hahn-Schickard at the University of Freiburg, Germany. He specializes in lab-on-a-chip systems, contact-free microdosage technologies and applications, miniaturized and implantable drug delivery systems, analysis and modeling of porous electrodes in batteries and fuel cells and biofuel cells.
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Organ-, Body- and Disease-on-a-Chip Thematic Collection

We are pleased to announce Lab on a Chip‘s first Thematic Collection in 2017, Organ-, Body- and Disease-on-a-Chip!

We are delighted to announce that Michael Shuler (Cornell University, USA) will be acting as Thought Leader for this collection. His research focuses on “Body-on-a-Chip” devices applied to evaluate different treatments for cancer, such as multi-drug resistant cancer. Read Michael Shuler’s recent Editorial for more information.

An emerging area of interest for drug development over the last 13 years has been constructing human biomimetic systems by combining the techniques of microfabrication and tissue engineering. In this collection, we define an “Organ-on-a-Chip” as a physical microscale model (typically an order of 10−6 to 10−4 of actual size) of a particular human organ.

The questions we aim to address in this collection are whether these emerging technologies will improve both drug development and the regulation of human exposure to chemicals. What technical challenges remain? What will be the most effective way to utilize this emerging technology? Can this technology lead to cost effective, measurable improvements in human health? Our goal is to highlight the new advances in this growing field with an emphasis on the interface between the technological advancements and high impact applications of organ-, body- and disease-on-a-chip technologies.

Interested in submitting to the collection? 

If you are interested in submitting to the series, please get in touch with the Lab on a Chip Editorial Office at loc-rsc@rsc.org and and provide a title and abstract of your proposed submission.

Articles will be published as they are accepted and collated into an online Thematic Collection, which will receive extensive promotion. Read the collection so far – rsc.li/organonachip

Submissions to this collection are open between 1st July 2017 and 31st March 2018

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Pioneers of Miniaturization Lectureship 2017

We are delighted to announce that Aaron Wheeler is 2017 winner of the “Pioneers of Miniaturization” Lectureship!

The 12th “Pioneers of Miniaturization” Lectureship, sponsored by Dolomite and Lab on a Chip , is for early to mid-career scientists who have made extraordinary or outstanding contributions to the understanding or development of miniaturised systems.

This “Pioneers of Miniaturization” Lectureship will be presented to Aaron at the µTAS 2017 Conference in Georgia, USA on 22-26 October 2017. Aaron will receive a certificate, a monetary award and will give a short lecture during the conference.

Many congratulations to Professor Aaron Wheeler on this achievement from the Lab on a Chip!

 

About the Winner

Aaron Wheeler earned his PhD in Chemistry at Stanford University in 2003. After a postdoctoral fellowship at UCLA, he joined the faculty at the University of Toronto in 2005, with primary appointment in the Department of Chemistry and cross-appointments in the Institute for Biomaterials and Biomedical Engineering and the Donnelly Centre for Cellular and Biomolecular Research.

Professor Wheeler has been recognized with a number of honours including the E.W.R. Steacie Memorial Fellowship from the Canadian National Sciences and Engineering Research Council, the Arthur F. Findeis Award from the American Chemical Society, and the Joseph Black Award from the Royal Society of Chemistry. He has authored more than 100 peer-reviewed publications and has served as Associate Editor of Lab on a Chip since 2013.

Wheeler’s research group develops microfluidic tools to solve problems in chemistry, biology, and medicine. A key technology used by the group is digital microfluidics  (DMF), a technique in which fluidic droplets are manipulated on the surface of an array of electrodes coated with a hydrophobic insulator. In recent years DMF has matured into a highly enabling liquid-handling technology which has a strong foothold in several fields ranging from chemical synthesis to clinical sample analysis to tissue engineering.

Learn about the Wheeler group online http://microfluidics.utoronto.ca/ or on twitter at @Wheeler_Lab.

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VIII International Congress on Analytical Nanoscience and Nanotechnology

The VIII International Congress on Analytical Nanoscience and Nanotechnology will be taking place in Barcelona, Spain on 3-5th July 2017. The aim of the conference is to bring together scientists working in the field of analytical nanoscience and nanotechnology to show their recent findings with interest for various applications.

The conference offers looks set to have a great program, including Plenary lectures from Advisory Board members Yoshinobu Baba (Nagoya University, Japan) and Anja Boisen (DTU, Denmark). Session topics include:

  • Lab on a Chip and Nanotechnology
  • Nanobiosensors: Sensors and Biosensors based on nanomaterials and nanostructures
  • Reliability and commercialization opportunities of Nanotechnological & Analytical Chemistry systems
  • Analysis at nanoscale

Register today to confirm you place!

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9th International Symposium on Microchemistry and Microsystems

9th International Symposium on Microchemistry and Microsystems (ISMM 2017) will be taking place in Tasmania, Australia on 26-29 June 2017. The conference is being run in conjunction with the 7th Advances in Microfluidics & Nanofluidics (AMN), the 5th Asia-Pacific Chemical and Biological Microfluidic Conference (APCBM) and the 8th Australia New Zealand Nano-Microfluidics Symposium (ANZNMF) and together promise to boast an exciting range of topics and talks from the microfluidics community.

This is the first major international meeting to be held in Australia with a strong focus on microfluidics and miniaturised chemistry, engineering and medicine, and will provide a unique opportunity and forum to discuss the latest developments in the field with researchers from all over the world.

Look our for Lab on a Chip Editorial Board member Yoon-Kyoung Cho (UNIST, South Korea) and Advisory Board member Amy E. Herr (US Berkeley, USA), who will both be giving Plenary lectures during the event and a Keynote lecture from Advisory Board member Qun Fang (Zhejiang University, China)

For full information about the conference and how to register, visit the conference website.

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Microfluidics, Physics & Chemistry of – Gordon Research Conference

Lab on a Chip is delighted to be a sponsor of: 

Microfluidics, Physics & Chemistry of  – Gordon Research Conference.

The event will take place on 4th – 9th June 2017 in Barga, Italy.

The conference brings together scientists, engineers and clinicians to discuss and advance cutting edge knowledge of microfluidics. Microfluidics are small scale systems that could be used to diagnose disease, enable unique physical and biological experiments and create new materials.

The goal of the 2017 meeting is to bridge the gap between scientists and engineers focused on fundamentals and those translating fundamental work into new applications. The conference is sure to spark animated discussion, new interactions and fruitful collaborations!

The conference will consist of topical sessions and active poster sessions. Topics include:

  • Point of Care Technologies
  • Nucleic Acid Analysis and Next Generation Sequencing
  • Fields, Forces, and Flows
  • Field-Structure Interactions
  • Wearable and Implantable Systems
  • Cell Mechanics
  • Living Systems
  • 3D Printing

The event is being chaired by Dino Di Carlo (UCLA, Lab on a Chip Editorial Board member) and Catherine M. Klapperich (Boston University) and vice chaired by Hang Lu (Georgia Institute of Technology, Lab on a Chip Associate Editor) and Cullen R. Buie (MIT).

Invited speakers include Lab on a Chip Advisory Board members Yanyi Huang (Peking University), Tony Huang (Duke University) and Albert Folch (University of Washington).

Apply by 7th May to secure your place!

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Transducers ’17

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Amy E. Herr – Our New Advisory Board Member!

 

We are delighted to announce our new Advisory Board member – Amy E. Herr!

Amy E. Herr is the Lester John & Lynne Dewar Lloyd Distinguished Professor of Bioengineering at the University of California, Berkeley and a Chan Zuckerberg (CZ) Biohub Investigator. Prior to joining UC Berkeley, she was a staff member at Sandia National Laboratories (Livermore, CA), earned Ph.D. and M.S. degrees in Mechanical Engineering from Stanford University, and completed her B.S. in Engineering and Applied Science with honors from the California Institute of Technology. Her research has been recognized by the NIH New Innovator Award, NSF CAREER Award, Alfred P. Sloan Fellowship (Chemistry), and DARPA Young Faculty Award. Professor Herr has chaired the Gordon Research Conference (GRC) on the Physics & Chemistry of Microfluidics. She is an elected Fellow of the American Institute of Medical and Biological Engineering (AIMBE), an entrepreneur, and was recently elected to the US National Academy of Inventors.  Her research program lies at the intersection of engineering design, analytical chemistry, and targeted proteomics – with a recent focus on cytometry spanning fundamental biological to clinical questions.

 

Read Amy’s recent papers in Lab an a Chip:

 

High-selectivity cytology via lab-on-a-disc western blotting of individual cells

John J. Kim, Elly Sinkala and Amy E. Herr

A lateral electrophoretic flow diagnostic assay

Robert Lin, Arunan Skandarajah, Rachel E. Gerver, Hector D. Neira, Daniel A. Fletcher and Amy E. Herr

 

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Hang Lu- Our new Associate Editor


We are delighted to announce our new Associate Editor – Hang Lu!

Hang Lu is the Love Family Professor of Chemical and Biomolecular Engineering at Georgia Tech. She graduated summa cum laude from UIUC with a B.S. in Chemical Engineering, and obtained her Ph.D. in Chemical Engineering in 2003 from MIT working with Klavs Jensen and Martin Schmidt. Before starting at Georgia Tech in 2005, she was a postdoc with neurogeneticist Cori Bargmann at UCSF and Rockefeller U. Her current research interests are microfluidics and its applications in neurobiology, systems biology, cancer, and biotechnology.

Hang has previously been a member of the Lab on a Chip Advisory Board. You can read some of her recent publications in the Journal below.

 

Hang will be handling papers from 1st February 2017, so submit your best work to her!

 

Hydrogel-droplet microfluidic platform for high-resolution imaging and sorting of early larval Caenorhabditis elegans

Auillaume Aubry, Mei Zhan and Hang Lu

An automated programmable platform enabling multiplex dynamic stimuli delivery and cellular response monitoring for high-throughput suspension single-cell signaling studies

Luye He, Ariel Kniss, Adriana San-Miguel, Tel Rouse, Melissa L. Kemp and Hang Lu

 

 

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