Author Archive

New YouTube Videos

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Emergent behavior in particle-laden microfluidic systems informs strategies for improving cell and particle separations

3D microfluidic chips with integrated functional microelements fabricated by a femtosecond laser for studying the gliding mechanism of cyanobacteria

On-chip magnetically actuated robot with ultrasonic vibration for single cell manipulations

Asynchronous magnetic bead rotation (AMBR) biosensor in microfluidic droplets for rapid bacterial growth and susceptibility measurements

Encapsulated droplets with metered and removable oil shells by electrowetting and dielectrophoresis

Magnetic micropillars as a tool to govern substrate deformations

A miniature capillary breakup extensional rheometer by electrostatically assisted generation of liquid filaments

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Top ten most accessed articles in March

This month sees the following articles in Lab on a Chip that are in the top ten most accessed:-

Miniaturized isothermal nucleic acid amplification, a review 
Peter J. Asiello and Antje J. Baeumner 
Lab Chip, 2011, 11, 1420-1430, DOI: 10.1039/C0LC00666A, Critical Review 

Stand-alone self-powered integrated microfluidic blood analysis system (SIMBAS) 
Ivan K. Dimov, Lourdes Basabe-Desmonts, Jose L. Garcia-Cordero, Benjamin M. Ross, Antonio J. Ricco and Luke P. Lee 
Lab Chip, 2011, 11, 845-850, DOI: 10.1039/C0LC00403K, Paper 

A software-programmable microfluidic device for automated biology 
Luis M. Fidalgo and Sebastian J. Maerkl 
Lab Chip, 2011, 11, 1612-1619, DOI: 10.1039/C0LC00537A, Paper 

Elastomeric membrane valves in a disc 
Hyundoo Hwang, Hak-Hyeon Kim and Yoon-Kyoung Cho 
Lab Chip, 2011, 11, 1434-1436, DOI: 10.1039/C0LC00658K, Communication 

Phaseguides: a paradigm shift in microfluidic priming and emptying 
Paul Vulto, Susann Podszun, Philipp Meyer, Carsten Hermann, Andreas Manz and Gerald A. Urban 
Lab Chip, 2011, 11, 1596-1602, DOI: 10.1039/C0LC00643B, Paper 

Microparticle and cell counting with digital microfluidic compact disc using standard CD drive 
Syed M. Imaad, Nathan Lord, Gulsim Kulsharova and Gang Logan Liu 
Lab Chip, 2011, 11, 1448-1456, DOI: 10.1039/C0LC00451K, Paper 

Capillary-driven automatic packaging 
Yuzhe Ding, Lingfei Hong, Baoqing Nie, Kit S. Lam and Tingrui Pan 
Lab Chip, 2011, 11, 1464-1469, DOI: 10.1039/C0LC00710B, Paper 

Three-dimensional interconnected microporous poly(dimethylsiloxane) microfluidic devices 
Po Ki Yuen, Hui Su, Vasiliy N. Goral and Katherine A. Fink 
Lab Chip, 2011, 11, 1541-1544, DOI: 10.1039/C0LC00660B, Technical Note 

Nanolitre droplet array for real time reverse transcription polymerase chain reaction 
Yunxia Zhang, Ying Zhu, Bo Yao and Qun Fang 
Lab Chip, 2011, 11, 1545-1549, DOI: 10.1039/C0LC00502A, Technical Note 

A magnetic bead-based assay for the rapid detection of methicill
Chih-Hung Wang, Kang-Yi Lien, Jiunn-Jong Wu and Gwo-Bin Lee
Lab Chip, 2011, 11, 1521-1531, DOI: 10.1039/C0LC00430H, Paper

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to Lab on a Chip? Then why not submit to us today or alternatively email us your suggestions.

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Top ten most accessed articles in February

This month sees the following articles in Lab on a Chip that are in the top ten most accessed:-

Microfluidics and complex fluids 
Ph Nghe, E. Terriac, M. Schneider, Z. Z. Li, M. Cloitre, B. Abecassis and P. Tabeling 
Lab Chip, 2011, 11, 788-794, DOI: 10.1039/C0LC00192A, Tutorial Review 

Rapid prototyping of microstructures in polydimethylsiloxane (PDMS) by direct UV-lithography 
Tim Scharnweber, Roman Truckenmüller, Andrea M. Schneider, Alexander Welle, Martina Reinhardt and Stefan Giselbrecht 
Lab Chip, 2011, 11, 1368-1371, DOI: 10.1039/C0LC00567C, Technical Note 

Continuous separation of breast cancer cells from blood samples using multi-orifice flow fractionation (MOFF) and dielectrophoresis (DEP) 
Hui-Sung Moon, Kiho Kwon, Seung-Il Kim, Hyunju Han, Joohyuk Sohn, Soohyeon Lee and Hyo-Il Jung 
Lab Chip, 2011, 11, 1118-1125, DOI: 10.1039/C0LC00345J, Paper 

nanoLAB: An ultraportable, handheld diagnostic laboratory for global health 
Richard S. Gaster, Drew A. Hall and Shan X. Wang 
Lab Chip, 2011, 11, 950-956, DOI: 10.1039/C0LC00534G, Paper 

Programmed trapping of individual bacteria using micrometre-size sieves 
Min-Cheol Kim, Brett C. Isenberg, Jason Sutin, Amit Meller, Joyce Y. Wong and Catherine M. Klapperich 
Lab Chip, 2011, 11, 1089-1095, DOI: 10.1039/C0LC00362J, Paper 

Lab-on-a-chip based immunosensor principles and technologies for the detection of cardiac biomarkers: a review 
Mazher-Iqbal Mohammed and Marc P. Y. Desmulliez 
Lab Chip, 2011, 11, 569-595, DOI: 10.1039/C0LC00204F, Tutorial Review 

Simple room temperature bonding of thermoplastics and poly(dimethylsiloxane) 
Vijaya Sunkara, Dong-Kyu Park, Hyundoo Hwang, Rattikan Chantiwas, Steven A. Soper and Yoon-Kyoung Cho 
Lab Chip, 2011, 11, 962-965, DOI: 10.1039/C0LC00272K, Technical Note 

Stand-alone self-powered integrated microfluidic blood analysis system (SIMBAS) 
Ivan K. Dimov, Lourdes Basabe-Desmonts, Jose L. Garcia-Cordero, Benjamin M. Ross, Antonio J. Ricco and Luke P. Lee 
Lab Chip, 2011, 11, 845-850, DOI: 10.1039/C0LC00403K, Paper 

Integrated systems for rapid point of care (PoC) blood cell analysis 
Cees van Berkel, James D. Gwyer, Steve Deane, Nicolas Green, Judith Holloway, Veronica Hollis and Hywel Morgan 
Lab Chip, 2011, 11, 1249-1255, DOI: 10.1039/C0LC00587H, Paper 

Affinity reagents for lab on chips 
Mathias Uhlen and Helene Andersson Svahn 
Lab Chip, 2011, Advance Article, DOI: 10.1039/C1LC90005F, Focus 

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to Lab on a Chip? Then why not submit to us today or alternatively email us your suggestions.

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New YouTube Videos for February

View the new videos on the Lab on a Chip YouTube site using the links below:

Magnetically-actuated artificial cilia for microfluidic propulsion

Separation of parasites from human blood using deterministic lateral displacement

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Thirty minute flu gene detector

Scientists in Japan have developed a portable influenza testing kit with better accuracy than current methods, which can give a result in 30 minutes.

Scientists from the Tokyo Medical and Dental University and Sony Corporation  made a nucleic acid amplification testing (NAT) device that not only gives information on the sample’s genetic make up to identify the flu pathogen type, but is also more than  90 per cent accurate. The device works by detecting the genes of the influenza virus pathogen – an organism that causes the disease – which gives information about the virus subtype and drug resistance.

Current rapid diagnostic kits to detect the flu virus suffer from low accuracy (40-69 per cent) and don’t provide genetic information about the sample. One NAT in use to test clinical specimens is real time reverse transcription polymerase chain reaction, which involves amplifying, detecting and quantifying DNA sequences. It does give genetic information, but it consists of a complex procedure and takes 3-4 hours to produce results. 

Sony’s detection system comprises: a laptop to control the system; a device for heating samples and detecting fluorescence; and disposable testing chips. The chips contain reaction wells made of polydimethylsiloxane sandwiched between two glass sheets in a vacuum chamber. Samples are injected into the wells through a port by a disposable injector, eliminating the need for pumps and tubing.

The detection system comprises: a laptop to control the system; a device for heating samples and detecting fluorescence; and disposable testing chips
The detection system comprises: a laptop to control the system; a device for heating samples and detecting fluorescence; and disposable testing chips 

Read the full article here 

Link to journal article
Point-of-care testing system enabling 30 min detection of influenza genes
Tomoteru Abe, Yuji Segawa, Hidetoshi Watanabe, Tasuku Yotoriyama, Shinichi Kai, Akio Yasuda, Norio Shimizu and Naoko Tojo,
Lab Chip, 2011, DOI: 10.1039/c0lc00519c

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New YouTube Videos

View the new videos on the Lab on a Chip YouTube site using the links below: 

3-Dimensional cell culture for on-chip differentiation of stem cells in embryoid body

Electrokinetic gated injection-based microfluidic system for quantitative analysis of hydrogen peroxide in individual HepG2 cells

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Chips make short work of RNA synthesis

Chinese scientists have developed a much easier way to make the short strands of RNA that are an essential tool in understanding what genes do.

Short interfering ribonucleic acids (siRNAs) were first discovered in 1999, and found to interfere with the expression of specific genes, giving them a key role in controlling the molecular machinery in living organisms. Though initially identified in plants, they were later found in animals too, and this spurred an interest in using them as tools to investigate what specific genes do in the body.

One type of siRNAs, endoribonuclease-prepared siRNAs (esiRNAs), has recently attracted attention because of their greater specificity and their cost effectiveness. Jianzhong Xi and colleagues at Peking University have now demonstrated a lab on a chip method that makes large scale manufacture of esiRNAs much easier.

The chip consists of 96 pins. Each pin has a polymer bead at its end in which a number of DNA probes are immobilised, allowing hundreds of esiRNA products to be manipulated at the same time

The chip consists of 96 pins. Each pin has a polymer bead at its end in which a number of DNA probes are immobilised, allowing hundreds of esiRNA products to be manipulated at the same time.

Read Catherine Bacon’s Chemistry World article online here or go straight to the HOT Lab on a Chip paper:

A polyacrylamide microbead-integrated chip for the large-scale manufacture of ready-to-use esiRNA
Huang Huang, Qing Chang, Changhong Sun, Shenyi Yin, Juan Li and Jianzhong Jeff Xi
Lab Chip, 2011, 11, Advance Article
DOI: 10.1039/C0LC00564A

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Top ten most accessed articles in December

This month sees the following articles in Lab on a Chip that are in the top ten most accessed:-

Simple room temperature bonding of thermoplastics and poly(dimethylsiloxane) 
Vijaya Sunkara, Dong-Kyu Park, Hyundoo Hwang, Rattikan Chantiwas, Steven A. Soper and Yoon-Kyoung Cho 
Lab Chip, 2011, Advance Article, DOI: 10.1039/C0LC00272K, Technical Note 

Stand-alone self-powered integrated microfluidic blood analysis system (SIMBAS) 
Ivan K. Dimov, Lourdes Basabe-Desmonts, Jose L. Garcia-Cordero, Benjamin M. Ross, Antonio J. Ricco and Luke P. Lee 
Lab Chip, 2011, Advance Article, DOI: 10.1039/C0LC00403K, Paper 

Hydrogel droplet microarrays with trapped antibody-functionalized beads for multiplexed protein analysis 
Huiyan Li, Rym Feriel Leulmi and David Juncker 
Lab Chip, 2011, 11, 528-534, DOI: 10.1039/C0LC00291G, Paper 

Optoelectrofluidic platforms for chemistry and biology
Hyundoo Hwang and Je-Kyun Park 
Lab Chip, 2011, 11, 33-47, DOI: 10.1039/C0LC00117A, Critical Review 

High-density fabrication of normally closed microfluidic valves by patterned deactivation of oxidized polydimethylsiloxane 
Bobak Mosadegh, Hossein Tavana, Sasha Cai Lesher-Perez and Shuichi Takayama 
Lab Chip, 2011, Advance Article, DOI: 10.1039/C0LC00112K, Technical Note

Mechanics of cell spreading within 3D-micropatterned environments 
Marion Ghibaudo, Jean-Marc Di Meglio, Pascal Hersen and Benoit Ladoux 
Lab Chip, 2011, Advance Article, DOI: 10.1039/C0LC00221F, Paper

Tackling HIV through robust diagnostics in the developing world: current status and future opportunities 
Darash Desai, Grace Wu and Muhammad H. Zaman 
Lab Chip, 2011, 11, 194-211, DOI: 10.1039/C0LC00340A, Tutorial Review 

Lung assist device technology with physiologic blood flow developed on a tissue engineered scaffold platform 
David M. Hoganson, Howard I. Pryor II, Erik K. Bassett, Ira D. Spool and Joseph P. Vacanti 
Lab Chip, 2011, Advance Article, DOI: 10.1039/C0LC00158A, Paper 

Some recent advances in the design and the use of miniaturized droplet-based continuous process: Applications in chemistry and high-pressure microflows 
Nicolas Lorber, Flavie Sarrazin, Pierre Guillot, Pascal Panizza, Annie Colin, Bertrand Pavageau, Cindy Hany, Patrick Maestro, Samuel Marre, Thomas Delclos, Cyril Aymonier, Pascale Subra, Laurent Prat, Christophe Gourdon and Emmanuel Mignard 
Lab Chip, 2011, Advance Article, DOI: 10.1039/C0LC00058B, Frontier 

Integrated microfluidic platform for the electrochemical detection of breast cancer markers in patient serum samples 
Alex Fragoso, Daniel Latta, Noemi Laboria, Frithjof von Germar, Thomas E. Hansen-Hagge, Wolfgang Kemmner, Claudia Gärtner, Richard Klemm, Klaus S. Drese and Ciara K. O’Sullivan 
Lab Chip, 2011, Advance Article, DOI: 10.1039/C0LC00398K, Paper 

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to Lab on a Chip? Then why not submit to us today or alternatively email us your suggestions.

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