Author Archive

Lab on a Chip thematic collection on droplet-based single cell sequencing

Lab on a Chip is delighted to share with you our Thematic Collection on droplet-based single-cell sequencing.

The droplet-based single-cell sequencing field is advancing very rapidly. Large numbers of studies are underway to collect and explore the new information that is now accessible with single-cell RNA-seq. Improvements to the microfluidics are also advancing rapidly. This collection of papers and reviews focusses on the between the technological advancements and high impact applications of droplet-based single-cell sequencing.

This topical and exciting collection is collated by Thought leader Dave Weitz and the Lab on a Chip Editorial Board. The collection is introduced in a perspective on single cell sequencing by the Thought leader Dave Weitz, and in two editorials, one on “InDrops and Drop-seq” by Allon Klein and Evan Macosko and one on “an engineer and business person’s perspective” by businessman and engineer Mark Gilligan.

Read the full collection at: http://rsc.li/drop-sc-seq

Below is a selection of content highlights featured in the collection. In addition, all papers are free to read until 31st May*

Perspective

Droplet-based single cell RNAseq tools: a practical guide

Robert Salomon, David Gallego-Ortega, et al.

Critical Review

Finding a helix in a haystack: nucleic acid cytometry with droplet microfluidics

Iain C. Clark and Adam R. Abate

Paper

High throughput gene expression profiling of yeast colonies with microgel-culture Drop-seq

Leqian Liu, Adam R. Abate, et al.

Paper

Simplified Drop-seq workflow with minimized bead loss using a bead capture and processing microfluidic chip

Marjan Biočanin, Bart Deplancke, et al.

Lab on a Chip is the leading journal publishing significant and original work related to miniaturisation, at the micro- and nano-scale, of interest to a multidisciplinary readership with an Journal Impact Factor of 5.995**. The journal is guided by Editor-in-Chief Abraham (Abe) Lee (University of California, Irvine) who is supported by our team of Associate Editors (Yoon-Kyoung Cho, Petra Dittrich, Hang Lu, Jianhua Qin, Manabu Tokeshi, Joel Voldman and Aaron Wheeler).

We hope you enjoy reading the papers within this Thematic Collection and we welcome future submissions on droplet-based single-cell sequencing.

Dolomite/Lab on a Chip Pioneers of Miniaturization Lectureshipdeadline approaching-nominate a colleague now!

Organ-on a-chip systems- translating concept into practice thematic collectionSubmit now

Organ-,body- and disease-on-a-chip thematic collectionRead now

Personalised medicine:liquid biopsyRead now

Lab on a Chip Emerging Investigator Series Apply now

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Lab on a Chip thematic collection on personalised medicine-liquid biopsy

Lab on a Chip is delighted to share with you our Thematic Collection on personalised medicine-liquid biopsy.

This collection of papers and reviews focusses on the interface between the technological advancements and high impact applications of liquid biopsy technologies. This collection is collated by Thought Leaders Mehmet Toner and Stefanie Jeffrey and the Lab on a Chip Editorial Board and is introduced in an Editorial by the Thought Leaders on Liquid biopsy: a perspective for probing blood for cancer

Read the full collection at: http://rsc.li/liquid-biopsy

Below is a selection of content highlights featured in the collection. In addition, all papers are free to read until 31st May*

Tutorial Review

Cancer diagnosis: from tumor to liquid biopsy and beyond

Ramanathan Vaidyanathan, Chwee Teck Lim, et al.

Critical Review

Circulating tumor DNA and liquid biopsy: opportunities, challenges, and recent advances in detection technologies

Lena Gorgannezhad, Nam-Trung Nguyen, Muhammad J. A. Shiddiky et al.

Paper

Dynamic CTC phenotypes in metastatic prostate cancer models visualized using magnetic ranking cytometry

Leyla Kermanshah, Shana O. Kelley et al.

Paper

An ultrasensitive test for profiling circulating tumor DNA using integrated comprehensive droplet digital detection

Chen-Yin Ou, Timothy J. Abram, Weian Zhao et al.

Paper

Cancer marker-free enrichment and direct mutation detection in rare cancer cells by combining multi-property isolation and microfluidic concentration

Soo Hyeon Kim, Teruo Fujii et al.

Paper

Urine-based liquid biopsy: non-invasive and sensitive AR-V7 detection in urinary EVs from patients with prostate cancer

Hyun-Kyung Woo, Hong Koo Ha, Yoon-Kyoung Cho et al.

 

Lab on a Chip is the leading journal publishing significant and original work related to miniaturisation, at the micro- and nano-scale, of interest to a multidisciplinary readership with an Journal Impact Factor of 5.995**. The journal is guided by Editor-in-Chief Abraham (Abe) Lee (University of California, Irvine) who is supported by our team of Associate Editors (Yoon-Kyoung Cho, Petra Dittrich, Hang Lu, Jianhua Qin, Manabu Tokeshi, Joel Voldman and Aaron Wheeler).

We hope you enjoy reading the papers within this Thematic Collection!

Keep up to date with Lab on a Chip throughout the year by signing up for free table of contents alerts and monthly e-newsletters.

Dolomite/Lab on a Chip Pioneers of Miniaturization Lectureshipdeadline approaching-nominate a colleague now!

Organ-on a-chip systems- translating concept into practice thematic collectionSubmit now

Organ-,body- and disease-on-a-chip thematic collectionRead now

Droplet-based single-cell sequencingRead now

Lab on a Chip Emerging Investigator Series Apply now

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

New YouTube Videos

Viscosity measurement based on the tapping-induced free vibration of sessile droplets using MEMS-based piezoresistive cantilevers 


 
 
  
An array microhabitat system for high throughput studies of microalgal growth under controlled nutrient gradients 


 
 
  
A Cost-Effective Fluorescence Mini-Microscope with Adjustable Magnifications for Biomedical Applications 

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

New YouTube Videos

Centrifugal microfluidic platform for single-cell level cardiomyocyte-based drug profiling and screening 


 
 
   
Size Reduction of Cosolvent-Infused Microbubbles to Form Acoustically Responsive Monodisperse Perfluorocarbon Nanodroplets 

 
 
   
A programmable microfluidic static droplet array for droplet generation, transportation, fusion, storage, and retrieval 

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

New YouTube Videos

One-Touch-Activated Blood Multidiagnostic System using a Minimally Invasive Hollow Microneedle Integrated with a Paper-Based Sensor 


 
   
 
Vortex Chain Formation in Regions of Ion Concentration Polarization 


 
 
  
 
Bi-content micro-collagen chip provides contractility-based biomechanical readout for phenotypic drug screening with expanded and profiled targets 

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

New YouTube Videos

Droplet-based microfluidics platform for measurement of rapid erythrocyte water transport 


 
 
  
 
Micromagnet arrays for on-chip focusing, switching, and separation of superparamagnetic beads and single cells 


 
 
  
 
Quantitative Dose-Response Curves from Subcellular Lipid Multilayer Microarrays 

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Free access to June’s HOT articles

These HOT articles published in June 2015 were recommended by our referees and are free* to access for 4 weeks

 

Microscale extraction and phase separation using a porous capillary
Thomas W. Phillips, James H. Bannock and John C. deMello  
Lab Chip, 2015,15, 2960-2967
DOI: 10.1039/C5LC00430F, Paper

Graphical abstract: Microscale extraction and phase separation using a porous capillary

 

Dielectrophoresis-assisted 3D nanoelectroporation for non-viral cell transfection in adoptive immunotherapy
Lingqian Chang, Daniel Gallego-Perez, Xi Zhao, Paul Bertani, Zhaogang Yang, Chi-Ling Chiang, Veysi Malkoc, Junfeng Shi, Chandan K. Sen, Lynn Odonnell, Jianhua Yu, Wu Lu and L. James Lee  
Lab Chip, 2015,15, 3147-3153
DOI: 10.1039/C5LC00553A, Paper

Graphical abstract: Dielectrophoresis-assisted 3D nanoelectroporation for non-viral cell transfection in adoptive immunotherapy

 

A microfluidic platform with digital readout and ultra-low detection limit for quantitative point-of-care diagnostics
Ying Li, Jie Xuan, Yujun Song, Ping Wang and Lidong Qin  
Lab Chip, 2015, Advance Article
DOI: 10.1039/C5LC00529A, Paper

Graphical abstract: A microfluidic platform with digital readout and ultra-low detection limit for quantitative point-of-care diagnostics

 

 *Access is free until 17.08.15 through a publishing personal account. It’s quick, easy and free to register

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

New YouTube Videos

Rapid and sensitive detection of antibiotic resistance on a programmable digital microfluidic platform 


 
 
   
Dielectrophoresis-assisted 3D nanoelectroporation for non-viral cell transfection in adoptive immunotherapy 


 
 
   
Reversible Thermo-Pneumatic Valves on Centrifugal Microfluidic Platforms 

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

New YouTube Videos

An acoustofluidic sputum liquefier 


 
   
 
Photopatterned oil-reservoir micromodels with tailored wetting properties 


 
  
 
Resonant dielectrophoresis and electrohydrodynamics for high-sensitive impedance detection of whole-cell bacteria 

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

New YouTube Videos

Multiplexed Paper Analytical Device for Measuring Airborne Metal Particulates with Distance-Based Detection 


 
  
 
Transportation, Dispersion and Ordering of Dense Colloidal Assemblies by Magnetic Interfacial Rotaphoresis 


 
   
Gecko Gaskets for Self-Sealing and High Strength Reversible Bonding of Microfluidics 

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)