HOT article: Low cost, miniaturised, thermoplastic SPR biosensor

SPR biosensorAs featured on the bright inside front cover of Issue 5, this HOT article from Teodor Veres and colleagues at the National Research Council and McGill University, Canada, steps towards low cost point-of-care sensors for disease diagnosis.

The team present their all-polymeric nanoplasmonic microfluidic (NMF) transmission surface plasmon resonance (SPR) biosensor. SPR, involving light stimulated electron oscillation, is advantageous for sensing as it means label-free, real-time detection with high throughput and automation. The device is miniaturised with a view to small, point-of-care applications. The approach involves nanostructures called nanogratings for transmission SPR, which gives a more stable response. The signal can be turned by altering their characteristics and they are easily fabricated en mass.

Thermoplastic materials present an advantage over traditional PDMS for such miniaturised SPR devices as they are more mechanically robust, inert, transparent and crucially viable for large scale production and commercial applications.  The novel aspect of this work is that the nanostructured surface and the microchannels are incorporated into one substrate quickly and at low cost. Thermoplastic valves are used in large numbers for the first time for a multiplex detection scheme.

They demonstrate its application in sensing glycoprotein sCD44 at picomolar to nanomolar concentrations. Further work by the group is focused on integrating this device with a CCD spectrometer.

See the design and performance results in the full paper, now available free for 4 weeks*:

All-thermoplastic nanoplasmonic microfluidic device for transmission SPR biosensing
Lidija Malic, Keith Morton, Liviu Clime and Teodor Veres
DOI: 10.1039/C2LC41123G

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

5 Responses to “HOT article: Low cost, miniaturised, thermoplastic SPR biosensor”

  1. If you’re nevertheless uncertain or maybe cannot bunch the major home equipment oneself, you can employ certainly one of respected Faridabad Packers Movers firms to address the work adequately.
    Packers and Movers in Faridabad
    Movers and Packers in Faridabad
    Packers and Movers in Noida
    Packers and Movers in Ghaziadabad
    Movers and Packers in Ghaziadabad
    Movers and Packers in Noida

  2. The majority of businesses usually are providing businesses inside of Chennai by way of while. They’ve purchased oral cavity click by way of Chennai.
    Movers and Packers in Chennai
    Movers and Packers in Hyderabad
    Movers and Packers in Bangalore
    Movers and Packers in Delhi

  3. SEO EXPERT says:

    If a potential client goes to your how to get instagram followers glitch account and sees something they like they will also for sure check out the comments that have been written for it, you need to be looking for gaining positive how to get instagram followers glitch comments, this is also key as it could make or break your business, again.

  4. Thanks for information Export5th company top services for packing and moving services in India
    Packers and Movers Gurgaon
    Packers and Movers Pune
    Packers and Movers Mumbai

Leave a Reply

*