Single-cell electrical lysis has been employed by Philip S. Low, Purdue University, and Chang Lu, Virginia Tech, to rapidly detect defects in the cytosketal protein network of individual red blood cells in a large cell population.
Statistically different profiles were detected for each mutation in defective membranes, which allowed subpopulations of red blood cells to be identified and demonstrates the promise of the technique for a rapid and sensitive detection of membrane defects.
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Single-cell electrical lysis of erythrocytes detects deficiencies in the cytoskeletal protein network
Ning Bao, Gayani C. Kodippili, Katie M. Giger, Velia M. Fowler, Philip S. Low and Chang Lu
DOI: 10.1039/C1LC20365G
