Administration of Gd-based MRI contrast agents causes major spectral interferences during analysis of selenium (Se) and platinum (Pt) in urine.
The finding was reported in a new study led by Amy Steuerwald who carried out an epidemiological study on 619 urine specimens to determine Se and Pt using quadruple-based inductively coupled plasma mass spectrometry (Q-ICP-MS). Both Se and Pt were several orders of magnitude greater than the upper limit of the population reference ranges.
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Trace element analysis of human urine collected after administration of Gd-based MRI contrast agents: characterizing spectral interferences using inorganic mass spectrometry
Amy J. Steuerwald , Patrick J. Parsons , John G. Arnason , Zhen Chen , C. Matthew Peterson and Germaine M. Buck Louis
J. Anal. At. Spectrom., 2013, Advance Article