We are delighted to announce the publication of Issue 11, Volume 6 of Integrative Biology, which is a themed issue dedicated to Computational Integrative Biology, guest edited by Jan Baumbach from the University of Southern Denmark.
The discovery of differentiated new medicines that provide clear benefits to patients remains challenging in spite of ever increasing investments. At the same time the quantity and diversity of patient related data continues to grow exponentially (pre-clinical data, clinical data, patient data, EHR, ‘OMICs data, and information associated with medicines in general). The scientific community is starting to leverage this wealth of information in ways that have the potential to disrupt the traditional drug discovery and development process as we know it.
Within this themed issue are five HOT research papers, which received particularly high scores during peer review – click on the links to download the articles*:
1. Researchers from the Imperial College London discuss the network wiring of pleiotropic kinases yields insight into protective role of diabetes on aneurysm.
2. Binding free energy based structural dynamics analysis of HIV-1 RT RNase H–inhibitor complexes, a research paper from scientists at the University of Southern Denmark.
3. Nataša Pržulj and colleagues give their approach on the integrated disease network.
4. Interesting research on multi-omics interactome analysis applied to the elucidation of epithelial–mesenchymal transition-related pathways
5. Our last HOT article is focused on an improved interolog mapping-based computational prediction of protein–protein interactions.
We hope you enjoy reading this collection as much as we did.
*Access is free until 24.11.14 through a registered RSC account – click here to register