Here at Integrative Biology, we would like to tell you about our most cited articles of 2010 and 2011, and to showcase some of the amazing and influential work that our authors have recently produced; a big congratulations to all.
As of now, all of the below articles will be free for 4 weeks (until Monday 16th Sept),* so make the most of this opportunity to download the full papers!
Top 3 Cited Reviews:
- S Kim et. al.: Biological applications of microfluidic gradient devices (DOI: 10.1039/c0ib00055h).
A critical review discussing the emergence of microfluidics-based gradient generators and their applications in enhancing our understanding of fundamental biological processes, including chemotaxis and morphogenesis.
- A Pathak et. al.: Biophysical regulation of tumor cell invasion: moving beyond matrix stiffness (DOI: 10.1039/c0ib00095g).
A critical review discussing the study of 3D extracellular matrix in cancer metastasis, with emphasis on the cell-matrix mechanical interactions that underlie the process of cell motility.
- CY Li et. al.: CFTR chloride channel in the apical compartments: spatiotemporal coupling to its interacting partners (DOI: 10.1039/b924455g).
A critical review on CFTR (cystic fibrosis transmembrane conductance regulator) and our current understanding its interactions with binding partners through PDZ scaffolding proteins.
Top 10 Cited Research Papers:
- JB Delehanty et. al.: Delivering quantum dot-peptide bioconjugates to the cellular cytosol: escaping from the endolysosomal system (DOI: 10.1039/c0ib00002g).
A study exploring a range of methods for the delivery of luminescent quantum dots to the cellular cytosol. Delehanty and colleagues demonstrated that an amphiphilic peptide designed to mediate cell penetration and vesicle membrane interactions could mediate rapid quantum dot uptake by endocytosis.
- CM Nelson et. al.: Endogenous patterns of mechanical stress are required for branching morphogenesis (DOI: 10.1039/c0ib00040j).
A paper showing that the pattern of branching morphogenesis of three-dimensional engineered epithelial tissues is controlled in part by gradients of endogenous mechanical stress.
- T Ellis et. al.: DNA assembly for synthetic biology: from parts to pathways and beyond (DOI: 10.1039/c0ib00070a).
A frontier paper on the assembly of large DNA constructs and its limitations in advancing synthetic biology. This review provides a critical examination of recent DNAassembly strategies and considers how this important facilitating aspect of synthetic biology may proceed in the future.
- KT Yong et. al.: Synthesis of ternary CuInS2/ZnS quantum dot bioconjugates and their applications for targeted cancer bioimaging (DOI: 10.1039/b916663g)
- JP Jung et. al.: Multifactorial optimization of endothelial cell growth using modular synthetic extracellular matrices (DOI: 10.1039/c0ib00112k)
- E Tumarkin et. al.: High-throughput combinatorial cell co-culture using microfluidics (DOI: 10.1039/c1ib00002k)
- L Rodriguez-Lorenzo et. al.: Intracellular mapping with SERS-encoded gold nanostars (DOI: 10.1039/c1ib00029b)
- DE Ingber et. al.: Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface beta 1 integrins (DOI: 10.1039/c0ib00034e)
- JI Lopez et. al.: In situ force mapping of mammary gland transformation (DOI: 10.1039/c1ib00043h)
- KR Sung et. al.: Transition to invasion in breast cancer: a microfluidic in vitro model enables examination of spatial and temporal effects (DOI: 10.1039/c0ib00063a)
*free through an RSC account