Mechanobiology, stem cells, predicting chemoresistance, retinopathy analysis and chemoattractant effects all in Integrative Biology Issue 3, online now!

The outside front cover of this month’s issue showcases a Frontier article from Yubing Sun and Jianping Fu at the University of Michigan on mechanobiology and stem cells, which was also featured in a recent blog post. They highlight just how vital understanding of the mechano-sensitive properties of stem cells is to being able to explore the abilities of stem cells. As a cover article, this is now free to access for 6 weeks*:

Mechanobiology: a new frontier for human pluripotent stem cells
Yubing Sun and Jianping Fu
DOI: 10.1039/C2IB20256E

This issue contains an important contribution from the team of Douglas Lauffenburger, Chair of the Editorial Board, at MIT, USA, in which they demonstrate the ability to characterise quantitative data on phenotypic behaviour of individual endothelial cells in response to angiogenesis signalling and relate it to overall population behaviour.  They show that the behaviour of microvascular endothelial cells in a single population is heterogeneous and cannot be assumed to be the same for all cells in a given condition.

Endothelial cell phenotypic behaviors cluster into dynamic state transition programs modulated by angiogenic and angiostatic cytokines
Tharathorn Rimchala, Roger D. Kamm and Douglas A. Lauffenburger
DOI: 10.1039/C2IB20090B

There are a number of other HOT articles, including:

An integrative network inference approach to predict mechanisms of cancer chemoresistance
Paola Lecca
DOI: 10.1039/C2IB20205K

Read the recent blog post on this article here!

Non-dimensional analysis of retinal microaneurysms: critical threshold for treatment
Elishai Ezra, Eliezer Keinan, Yossi Mandel, Michael E. Boulton and Yaakov Nahmias
DOI: 10.1039/C3IB20259C

Read the recent blog post on this article here!

Convolution of chemoattractant secretion rate, source density, and receptor desensitization direct diverse migration patterns in leukocytes
Yana Wang and Darrell J. Irvine
DOI: 10.1039/C3IB20249F

 For the full online contents list, click here!

 *Free access to individuals is provided through an RSC Publishing personal account. Registration is quick, free and simple

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