Vadim Mozhayskiy and Ilias Tagkopoulos at the UC Davis Genome Center, University of California Davis, USA, take a critical look at in vivo and in silico techniques that have been developed to study the evolution of microbial organisms and their sophisticated characteristics. They go even further and contemplate how these two separate approaches can be combined into one to gain more information for more complex environments.
This critical review includes
- The advantages and challenges of controlled laboratory evolution of microorganisms
- The role of mathematical multiscale modelling and supercomputer simulation
- The balancing act of creating biologically realistic but computationally feasible in silico models
Read this interesting review in full:
Microbial evolution in vivo and in silico: methods and applications
Vadim Mozhayskiy and Ilias Tagkopoulos