Carbon nanotube sheets to control stem cell differentiation and in vivo thrombin detection on the cover of Issue 6

On the covers this issue we have articles from Tai Hyun Park et al and Quyen Nguyen et al.

Tai Hyun Park and colleagues have used multi-walled carbon nanotube sheets as a matrix to control the differentiation and direction of stem cell growth into neural cells.  The MWCNTs directed the growth pattern of axons, and could open up new avenues for tissue and stem cell regeneration with regenerative medicine applications.

Regulation of morphogenesis and neural differentiation of human mesenchymal stem cells using carbon nanotube sheets
Jeong Ah Kim, Eui Yun Jang, Tae June Kang, Sungjun Yoon, Raquel Ovalle-Robles, Won Jong Rhee, Taewoo Kim, Ray H. Baughman, Yong Hyup Kim and Tai Hyun Park
Integr. Biol., 2012, 4, 587-594
DOI: 10.1039/C2IB20017A

Our other cover article is from Quyen Nguyen and team, which included Nobel Laureate Roger Tsein, who have developed an imaging probe which can be used in vivo to detect thrombin in plagues.  They hope that the sensitive probe could eventually be used clinically to detect and diagnose atherosclerosis non-invasively, in a similar way to tumour detection by MRI.

In vivo fluorescence imaging of atherosclerotic plaques with activatable cell-penetrating peptides targeting thrombin activity
Emilia S. Olson, Michael A. Whitney, Beth Friedman, Todd A. Aguilera, Jessica L. Crisp, Fred M. Baik, Tao Jiang, Stephen M. Baird, Sotirios Tsimikas, Roger Y. Tsien and Quyen T. Nguyen
Integr. Biol., 2012, 4, 595-605
DOI: 10.1039/C2IB00161F

Also in this issue we have HOT articles on understanding the ability of T-cells to stop at a site of infection and inducing cellular remodelling in mechanotransduction processes.

View the rest of the issue here!

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