Archive for the ‘Reviews’ Category

Turning natural cofactors into new anti-proliferative agents

Peptide B12: emerging trends at the interface of inorganic chemistry, chemical biology and medicineVitamin B12 plays an important role in the metabolism of many organisms, particularly mammals.  Since efficient delivery of vitamin B12 into cells has potential applications in medical therapies, Zelder et al. are sure to inspire wider interest in the design, chemistry and biology of backbone modified B12 derivatives with this hot Perspective.

Download the Perspective today for free

Peptide B12: emerging trends at the interface of inorganic chemistry, chemical biology and medicine
Felix Zelder, Kai Zhou and Marjorie Sonnay
Dalton Trans., 2013
DOI: 10.1039/C2DT32005C

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Inspiring inorganic chemists to make their mark in medicine

Declan Gaynor and Darren Griffith discuss how medicinal inorganic chemistry is currently flourishing in this Dalton Transactions Perspective.  Understanding the role of metals in biological systems is very important for drug design; the predictability and control of inorganic complexes make fine-tuning the properties of drugs incorporating such complexes a real possibility.  Metal-based compounds are already routinely administered on a regular basis and this Perspective encourages chemists to further investigate inorganic therapeutic and diagnostic medicine by looking at previous successes, e.g. MRI contrast agents, then moving onto current challenges such as antibacterial compounds for tackling hospital acquired infections.Key areas of applied medicinal inorganic chemistryKey areas of applied medicinal inorganic chemistry

To find out more, you can download the Perspective now – which is free to access for 4 weeks!

The prevalence of metal-based drugs as therapeutic or diagnostic agents: beyond platinum
Declan Gaynor and Darren M. Griffith
Dalton Trans., 2012
DOI: 10.1039/C2DT31601C, Perspective

Also of interest…

Mn(II) complexes of novel hexadentate AAZTA-like chelators: a solution thermodynamics and relaxometric study
Lorenzo Tei, Giuseppe Gugliotta, Marianna Fekete, Ferenc K. Kálmán and Mauro Botta
Dalton Trans., 2011, 40, 2025-2032
DOI: 10.1039/C0DT01114B, Paper

Metallic radionuclides in the development of diagnostic and therapeutic radiopharmaceuticals
Sibaprasad Bhattacharyya and Manish Dixit
Dalton Trans., 2011, 40, 6112-6128
DOI: 10.1039/C1DT10379B, Perspective
From themed issue Radiopharmaceuticals for imaging and therapy

The status of platinum anticancer drugs in the clinic and in clinical trials
Nial J. Wheate, Shonagh Walker, Gemma E. Craig and Rabbab Oun
Dalton Trans., 2010, 39, 8113-8127
DOI: 10.1039/C0DT00292E, Perspective

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Hot Perspective: Treating Wilsons Disease

Wilson’s disease is a rare genetic condition caused by inheriting an abnormal copy of the Wilson disease protein (ATP7B) gene. The disease affects approximately 1-4 people per 100,000 and prevents sufferers from regulating the concentration of copper within their body, inducing a copper overload.

The redox properties of copper make it a very important metal biologically and it is involved in a wide range of enzymatic processes. The anti-oxidant enzyme superoxide dismutase for example is expressed in all cells and is part of our anti-oxidant defence, while the more specialised dopamine β-hydroxylase is only expressed in the brain and is involved in dopamine conversion. Balancing the amount of copper we have in our bodies is crucial for good health, having a copper deficit would hinder vital functions, but having an excess can cause oxidative stress by promoting the formation of hydroxyl radicals.

Designing new drugs to treat Wilson’s disease which can be targeted to the liver, where excess copper is found

Treating Wilson’s disease involves life-long chelation therapy, this is the application of compounds designed to bind to the excess copper ions and allow them to be safely excreted. This Hot Perspective by Pascale Delangle and Elisabeth Mintz reviews the drugs currently in use and gives insight in to the development of more advanced treatments, highlighting the design of bio-inspired chelating agents and drug targeting.

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To find out more you can download this article now, which is free to access for 4 weeks!
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Chelation therapy in Wilson’s disease: from D-penicillamine to the design of selective bioinspired intracellular Cu(I) chelators
Pascale Delangle and Elisabeth Mintz
Dalton Trans., 2012, Advance Article
DOI: 10.1039/C2DT12188C

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Porphyrinic MOFs

If you’re interested in finding out more about MOFs, and in particular those based on metalloporphyrins, then look no further… Chao Zou and Chuan-De Wu’s recent Perspective article provides an interesting overview of these functional materials. The researchers from Zhejiang University, China, discuss synthetic strategies and applications ranging from hydrogen storage to photocatalysis. Although the application of porphyrinic MOFs is considerably underdeveloped compared to other porphyrinic materials, say Zou and Wu, this article demonstrates that metalloporphyrins are an ideal choice for designing crystalline solid frameworks.

To read more, download the article now – it’s free to access.
Functional porphyrinic metal–organic frameworks: crystal engineering and applications

This Perspective article is part of the upcoming themed issue on Coordination Chemistry in the Solid State, guest edited by Dalton Transactions Associate Editor, Russell Morris. Keep your eyes peeled for many of our other coordination chemistry articles which have already been published, including Burnett and Choe’s Perspective article on “Sequential self-assembly in metal–organic frameworks”.

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Hot Frontier: Pharmaceutical potential of selenium and tellurium compounds

Edward Tiekink is based at the University of Malaya

Edward Tiekink gives us a concise overview of drug developments involving selenium and tellurium compounds in this Dalton Transactions Frontier.

Download it today, whilst it is still free….

Therapeutic potential of selenium and tellurium compounds: Opportunities yet unrealised
Edward R. T. Tiekink
Dalton Trans., 2012
DOI: 10.1039/C2DT12225A

Why not take a look at some of Edward Tiekink’s other recent articles:

The metal–carbonyl···π(aryl) interaction as a supramolecular synthon for the stabilisation of transition metal carbonyl crystal structures
Julio Zukerman-Schpector, Ionel Haiduc and Edward R.T. Tiekink
Chem. Commun., 2011, 47, 12682-12684
DOI: 10.1039/C1CC15579B, Communication

Interwoven coordination polymers sustained by tautomeric forms of the bridging ligand
Pavel Poplaukhin and Edward R. T. Tiekink
CrystEngComm, 2010, 12, 1302-1306
DOI: 10.1039/B916585A, Paper

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Metal complexes as biomolecular probes

Kenneth Kam-Wing Lo

The rich photophysical properties of luminescent inorganic and organometallic transition metal complexes, such as their intense, long-lived, and environment-sensitive emission, make them excellent candidates for biological and cellular probes. In this Dalton Transactions Perspective, Ken Lo and colleagues review examples of biological probes derived from luminescent transition metal complexes with a d6, d8, or d10 metal center.  Also discussed is the possible use of luminescent transition metal complexes as photodynamic therapeutics for various diseases or even light-activated drug release moelcules.

Applications of luminescent inorganic and organometallic transition metal complexes as biomolecular and cellular probes
Kenneth Kam-Wing Lo, Alex Wing-Tat Choi and Wendell Ho-Tin Law
Dalton Trans., 2012, DOI: 10.1039/C2DT11892

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First came Pacman, then Ms. Pacman and now Diamido Pacman!?

Multi-dentate amido ligands are a real area of interest in coordination chemistry, the transition metal complexes possess novel reactivities, interesting structures and a range of properties including magnetism. Diamido-donor ligands for a large number of diamagnetic metal centres have been well studied, but the paramagnetic complexes have been relatively unexplored. Daniel B. Leznoff and Cassandra E. Hayes have compiled a review of these interesting structures in their Dalton Transactions Perspective ‘Paramagnetic metal complexes of diamido donor ligands‘, highlighting the broad scope of research yet to be undertaken. Who knows where the next fruit will appear in this unexplored maze?

Paramagnetic metal complexes of diamido donor ligands
Cassandra E. Hayes and Daniel B. Leznoff
Dalton Trans., 2012, Advance Article
DOI: 10.1039/C1DT11559F

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Hot Perspective: Shedding light on the oxygen-evolving-complex

Can we mimic the Photosystem II machinery for light-driven oxidation of water to molecular oxygen?

Can we mimic the Photosystem II machinery for light-driven oxidation of water to molecular oxygen?

In this Dalton Transactions Perspective, Philipp Kurz and colleagues discuss manganese-containing compounds that have been studied as potential analogues of the oxygen-evolving-complex in Photosystem II.  They highlight how the desire to produce solar fuels is inspiring research into artificial photosynthesis.

Read more for free until 29th November at:

Water oxidation catalysed by manganese compounds: from complexes to ‘biomimetic rocks’
Mathias Wiechen, Hans-Martin Berends and Philipp Kurz
Dalton Trans., 2012, Advance Article
DOI: 10.1039/C1DT11537E, Perspective

You might also find these Dalton Trans. articles on biomimetic water-oxidation catalysis interesting…

Nano-size amorphous calcium–manganese oxide as an efficient and biomimetic water oxidizing catalyst for artificial photosynthesis: back to manganese
Mohammad Mahdi Najafpour, Sara Nayeri and Babak Pashaei
Dalton Trans., 2011, 40, 9374-9378
DOI: 10.1039/C1DT11048A

High turnover catalysis of water oxidation by Mn(II) complexes of monoanionic pentadentate ligands
Rune Kirk Seidler-Egdal, Anne Nielsen, Andrew D. Bond, Morten J. Bjerrum and Christine J. McKenzie
Dalton Trans., 2011, 40, 3849-3858
DOI: 10.1039/C0DT01340D

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Perspective: Suning Wang on triarylboron compounds for optoelectronics

Suning Wang from Queen’s University, Canada, looks at how electron accepting triarylboranes can be used in optoelectronic applications in this Dalton Transactions Perspective article.

Wang and her PhD student, Zachary Hudson, discuss the role of boron, and the photophysical properties of metal-containing triarylboranes. They go on to review the recent research, looking at triarylboron-containing complexes in OLEDs and as anion sensors, as well their use in MOFs, zinc sensors and as vapochromic materials to detect VOCs.

Read the full article to find out more…

Metal-containing triarylboron compounds for optoelectronic applications
Zachary M. Hudson and Suning Wang
Dalton Trans., 2011, 40, 7805-7816
DOI: 10.1039/C1DT10292C

Professor Wang is an Associate Editor for our new journal, RSC Advances, read more about her research.

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The Future of MOFs?

Neil Champness

We all know that MOFs are everywhere now but where are they going? Neil Champness provides us with his expert point of view on the future of metal-organic frameworks  in his recently published Dalton Transactions Frontier article. Find out where the challenges currently lie and the opportunities on the horizon for these hot hot compounds.

You can even download and read Neil’s exciting Frontier for free until the 4th October! Just click on the article title below:
The future of metal–organic frameworks
Neil R. Champness  
Dalton Trans., 2011, DOI: 10.1039/C1DT11184A

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