Archive for the ‘Hot Articles’ Category

Hot Paper: Schiff base-cobalt(II) coordination polymer with anti-cancer activity

The ligand, 2-oxo-1,2-dihydroquinoline-3-carbaldehyde (isonicotinic) hydrazone, is coordinated through the ONO donor atoms to one   Co(II) metal center and bridged through the pyridine nitrogen atom to another similar Co(II) center to form a 1D polymeric unit.

The ligand, 2-oxo-1,2-dihydroquinoline-3-carbaldehyde (isonicotinic) hydrazone, is coordinated through the ONO donor atoms to one Co(II) metal center and bridged through the pyridine nitrogen atom to another similar Co(II) center to form a 1D polymeric unit.

Karuppannan Natarajan and colleagues have synthesised and characterised the Co(II) complex, {[Co(H2L)(H2O)2](NO3)2·3H2O}n.  Human cancer cytotoxicity studies have shown the complex is very specific for cancer cells and less toxic in comparison to the well-know cancer drug, cisplatin.

To find out more you can download this article now, which is free to access for 4 weeks!

A novel water soluble ligand bridged cobalt(II) coordination polymer of 2-oxo-1,2-dihydroquinoline-3-carbaldehyde (isonicotinic) hydrazone: evaluation of the DNA binding, protein interaction, radical scavenging and anticancer activity
Duraisamy Senthil Raja,  Nattamai S. P. Bhuvanesh and Karuppannan Natarajan
Dalton Trans., 2012
DOI: 10.1039/C2DT12274J

Take a look at some of the other papers published recently in Dalton Transactions on Schiff base complexes of transition metal ions…

Structural and luminescence studies of nickel(II) and copper(II) complexes with (1R,2R)-cyclohexanediamine derived unsymmetric Schiff base
Magdalena Barwiolek, Edward Szlyk, Tadeusz M. Muzioł and Tadeusz Lis
Dalton Trans., 2011, 40, 11012-11022
DOI: 10.1039/C1DT10882D

The unprecedented preparation of dinuclear zinc(II) complexes from 4-halido-2-[(3-cyclohexylaminopropylimino)methyl]phenol
Zhong-Lu You, Mei Zhang and Dong-Mei Xian
Dalton Trans., 2012, 41, 2515-2524
DOI: 10.1039/C1DT11566A

Heterocyclic dithiocarbazate iron chelators: Fe coordination chemistry and biological activity
Maram T. Basha, Jy D. Chartres, Namfon Pantarat, Mohammad Akbar Ali, Aminul Huq Mirza, Danuta S. Kalinowski, Des R. Richardson and Paul V. Bernhardt
Dalton Trans., 2012
DOI: 10.1039/C2DT12387H

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Organoimido derivatives of POMs

Polyoxometalates (POMs) are interesting inorganic compounds that contain transition metal ions linked together by bridging oxygen atoms to form large three dimensional frameworks. Even though POMs have been studied for a long time (the first polyoxometalate was reported nearly 200 years ago by the Swedish chemist, Jons Jacob Berzelius), there has been limited success in producing practical and functional materials.

By replacing the oxo bridging groups with organic ligands, researchers can develop new strategies for synthesising novel POM-based organic-inorganic hybrid materials through linking POMs and organic compounds together by covalent bonds. Of particular interest are the organoimido POM derivatives.

In their latest HOT Perspective article, a team of researchers from Tsinghua University, China, explore the synthetic chemistry of organoimido derivatives of POMs and the reactive chemistry for the construction of POM-based hybrid materials.  Wei et al. highlight that both the inorganic cluster skeleton and the organic ligand in organoimido-based POMs can act as reactive sites which could lead to an exciting future for the chemistry of organoimido based POMs.

To find out more, download the full article which is free to access until 26th March…
The chemistry of organoimido derivatives of polyoxometalates
Jin Zhang,  Fengping Xiao, Jian Hao and Yongge Wei

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Hot Perspective: Treating Wilsons Disease

Wilson’s disease is a rare genetic condition caused by inheriting an abnormal copy of the Wilson disease protein (ATP7B) gene. The disease affects approximately 1-4 people per 100,000 and prevents sufferers from regulating the concentration of copper within their body, inducing a copper overload.

The redox properties of copper make it a very important metal biologically and it is involved in a wide range of enzymatic processes. The anti-oxidant enzyme superoxide dismutase for example is expressed in all cells and is part of our anti-oxidant defence, while the more specialised dopamine β-hydroxylase is only expressed in the brain and is involved in dopamine conversion. Balancing the amount of copper we have in our bodies is crucial for good health, having a copper deficit would hinder vital functions, but having an excess can cause oxidative stress by promoting the formation of hydroxyl radicals.

Designing new drugs to treat Wilson’s disease which can be targeted to the liver, where excess copper is found

Treating Wilson’s disease involves life-long chelation therapy, this is the application of compounds designed to bind to the excess copper ions and allow them to be safely excreted. This Hot Perspective by Pascale Delangle and Elisabeth Mintz reviews the drugs currently in use and gives insight in to the development of more advanced treatments, highlighting the design of bio-inspired chelating agents and drug targeting.

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To find out more you can download this article now, which is free to access for 4 weeks!
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Chelation therapy in Wilson’s disease: from D-penicillamine to the design of selective bioinspired intracellular Cu(I) chelators
Pascale Delangle and Elisabeth Mintz
Dalton Trans., 2012, Advance Article
DOI: 10.1039/C2DT12188C

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To stay up to date with the latest news in inorganic chemistry you can also follow us on twitter and sign up to our e-alert service.

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HOT Article: Anti-microbials that target destabilised DNA

Dinuclear ruthenium complex ΔΔ-Rubb7 selectively binds a destabilised segment of DNA

Richard Keene and colleagues report an inert dinuclear polypyridylruthenium(II) groove binding metal complex that exhibits slow exchange DNA binding in this HOT article.  Such compounds have potential as anti-microbial agents as they can block the interaction of important proteins with DNA.

For more details, download the article which is free to access for 4 weeks.

An approach to therapeutic agents through selective targeting of destabilised nucleic acid duplex sequences

Fangfei Li,  Daniel K. Weber,  Joy L. Morgan,  J. Grant Collins and F. Richard Keene
Dalton Trans., 2012
DOI: 10.1039/C2DT12146H

This paper is part of forthcoming themed issue on Application of Inorganic Chemistry for non-Cancer Therapeutics. Here are some other articles due to be published in this issue….

Interference of a new cyclometallated Pt compound with Cu binding to amyloid-ß peptide
Isabelle Sasaki ,  Christian Bijani ,  Sonia Ladeira ,  Valérie Bourdon ,  Peter Faller and Christelle Hureau
Dalton Trans., 2012
DOI: 10.1039/C2DT12177H

In vitro inhibitory properties of ferrocene-substituted chalcones and aurones on bacterial and human cell cultures
Keshri Nath Tiwari,  Jean-Philippe Monserrat,  Arnaud Hequet,  Carine Ganem-Elbaz,  Thierry Cresteil,  Gérard Jaouen,  Anne Vessières,  Elizabeth A. Hillard and Claude Jolivalt
Dalton Trans., 2012
DOI: 10.1039/C2DT12180H

Polyanionic N-donor ligands as chelating agents in transition metal complexes: synthesis, structural characterization and antiviral properties against HIV
Sandra García-Gallego,  Javier Sánchez Rodríguez,  José Luis Jiménez,  Michela Cangiotti,  Maria Francesca Ottaviani,  M. Ángeles Muñoz-Fernández,  Rafael Gómez and F. Javier de la Mata
Dalton Trans., 2012
DOI: 10.1039/C2DT11793B

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HOT Article: Trifluoroacetate decomposition with coinage metals

The presence of C–F bonds in organic compounds has a dramatic influence on their physical, chemical and biological properties.  Metal mediated reactions that result in C–F bond formation or C–F bond activation have attracted considerable attention as the demand for organofluorine compounds has increased. Metal-catalysed decarboxylative cross-coupling reactions using trifluoracetate as a cheap source of  introducing “CF3” represents an attractive approach.  Until now, little has been known about the fragmentation mechanisms of metal trifluoracetates.   In this Dalton Transactions HOT article,  Rijs and O’Hair use a combination of gas-phase 3D quadrupole ion trap mass spectrometry experiments and density functional theory (DFT) calculations to examine the mechanism of thermal decomposition of fluorinated coinage metal carboxylates.  Synthetic chemists should be able to use these results to design new ways of incorporating CF3 and F fragments using trifluoroacetate.

Read more for FREE until the 13th March 2012 at:

Forming trifluoromethylmetallates: competition between decarboxylation and C–F bond activation of group 11 trifluoroacetate complexes, [CF3CO2ML]
Nicole J. Rijs and Richard A. J. O’Hair
Dalton Trans., 2012, Advance Article
DOI: 10.1039/C2DT12117D

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How big is a Cp?

Ferrocene is a sandwich complex of two cyclopentadienyl (Cp) units bound to an Fe centre and is probably the most famous organometallic compound containing a Cp ligand. There are a huge variety of organometallic complexes with a range of metal centres and ligands and there is a great deal of interest in their structural, chemical and physical properties.

This Hot Article details the preparation of a series of [(η7-C7H7)Zr(η5-L)] (L = Cp and Ind) complexes and their structural characterisation. The authors use this information to develop a system to measure the steric bulk of Cp ligands………..so how big is a Cp?

To find out, you can download this article now, which is free to access for 4 weeks

How big is a Cp? Cycloheptatrienyl zirconium complexes with bulky cyclopentadienyl and indenyl ligands
Andreas Glöckner, Heiko Bauer, Miyuki Maekawa, Thomas Bannenberg, Constantin G. Daniliuc, Peter G. Jones, Yu Sun, Helmut Sitzmann, Matthias Tamm and Marc D. Walter
Dalton Trans., 2012, Advance Article
DOI: 10.1039/C2DT12132H

You can also keep up-to-date with the latest news in Dalton Transactions by following us on twitter or signing up to our e-alert service.

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Porphyrinic MOFs

If you’re interested in finding out more about MOFs, and in particular those based on metalloporphyrins, then look no further… Chao Zou and Chuan-De Wu’s recent Perspective article provides an interesting overview of these functional materials. The researchers from Zhejiang University, China, discuss synthetic strategies and applications ranging from hydrogen storage to photocatalysis. Although the application of porphyrinic MOFs is considerably underdeveloped compared to other porphyrinic materials, say Zou and Wu, this article demonstrates that metalloporphyrins are an ideal choice for designing crystalline solid frameworks.

To read more, download the article now – it’s free to access.
Functional porphyrinic metal–organic frameworks: crystal engineering and applications

This Perspective article is part of the upcoming themed issue on Coordination Chemistry in the Solid State, guest edited by Dalton Transactions Associate Editor, Russell Morris. Keep your eyes peeled for many of our other coordination chemistry articles which have already been published, including Burnett and Choe’s Perspective article on “Sequential self-assembly in metal–organic frameworks”.

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Hot Frontier: Pharmaceutical potential of selenium and tellurium compounds

Edward Tiekink is based at the University of Malaya

Edward Tiekink gives us a concise overview of drug developments involving selenium and tellurium compounds in this Dalton Transactions Frontier.

Download it today, whilst it is still free….

Therapeutic potential of selenium and tellurium compounds: Opportunities yet unrealised
Edward R. T. Tiekink
Dalton Trans., 2012
DOI: 10.1039/C2DT12225A

Why not take a look at some of Edward Tiekink’s other recent articles:

The metal–carbonyl···π(aryl) interaction as a supramolecular synthon for the stabilisation of transition metal carbonyl crystal structures
Julio Zukerman-Schpector, Ionel Haiduc and Edward R.T. Tiekink
Chem. Commun., 2011, 47, 12682-12684
DOI: 10.1039/C1CC15579B, Communication

Interwoven coordination polymers sustained by tautomeric forms of the bridging ligand
Pavel Poplaukhin and Edward R. T. Tiekink
CrystEngComm, 2010, 12, 1302-1306
DOI: 10.1039/B916585A, Paper

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HOT Article: Catalyst with magnetic recovery

Jie-Sheng Chen and colleagues from Shanghai Jiao Tong University report the synthesis of a Pd/Fe3O4 nanocomposite that can be used as a heterogeneous catalyst for the hydrogenation of p-nitrophenol.  Convenient recycling of the catalyst using a magnet is possible – find out more by downloading the article whilst it’s free to access:

Controlled synthesis of magnetic Pd/Fe3O4 spheres via an ethylenediamine-assisted route
Hai-Qun Wang, Xiao Wei, Kai-Xue Wang and Jie-Sheng Chen
Dalton Trans., 2012
DOI: 10.1039/C2DT12278B

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Hot Article: Le Bail fitting used to extract single-crystal diffraction data

A team of researchers have determined the structure of metastable compound Bi2MnxAl7−xO14, an intermediate phase in the decomposition of mullite-Bi2MnxAl4-xO9+δ, using a strategy  that included the use of a charge-flipping algorithm and Monte-Carlo based simulations.  The strategy may be particularly useful in situations where it is difficult to get high quality crystals.

The article is currently free so download it today.

Mullite-derivative Bi2MnxAl7−xO14 (x ~ 1): structure determination by powder X-ray diffraction from a multi-phase sample
Tao Yang,  Vaclav Petricek,  Wei Wan,  Zidong Wei and Junliang Sun
Dalton Trans., 2012
DOI: 10.1039/C2DT11855F

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