Scientists in Mexico have devised a new synthetic pathway to a nitrogen-containing ligand, which, when bound to divalent nickel or manganese, is a 1000 times more effective than the leading clinical drug at reducing the profileration of the parasite responsible for amoebiasis. This disease causes 70 thousand deaths a year.
The same ligand bound to other divalent metal ions also shows remarkable anti-cancer properties with activities superior to cisplatin.
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Potential cytotoxic and amoebicide activity of first row transition metal compounds with 2,9-bis-(2′,5′-diazahexanyl)-1,1-phenanthroline (L1)
Juan Carlos García-Ramos, Yanis Toledano-Magaña, Luis Gabriel Talavera-Contreras, Marcos Flores-Álamo, Vanessa Ramírez-Delgado, Emmanuel Morales-León, Luis Ortiz-Frade, Anllely Grizett Gutiérrez, Adriana Vázquez-Aguirre, Carmen Mejía, Julio César Carrero, Juan Pedro Laclette, Rafael Moreno-Esparza and Lena Ruiz-Azuara