Shining light on the Hantzsch reaction

This article is HOT as recommended by the referees

Scientists from the Indian Institute of Technology have investigated the effect of visible light on the Hantzsch reaction – a method by which to produce dihydropyridines which have found merit for cardiovascular disease treatment. By doing so, they were able to develop a photocatalytic-based methodology for producing 2-arylpyridines. Whilst such compounds are popular in medicinal chemistry and supramolecular coordination chemistry fields, their synthesis can be troublesome.

Armed with a catalytic amount of [Ru(bpy)3]2+ and a household compact fluorescent lamp, the team synthesised the 2-arylpyridine compound through photocatalytic oxidation of the 1,2-dihydropyridine Hantzsch product.

For further details on the reaction conditions and mechanism, read the the Full Paper:
[Ru(bpy)3]2+ Aided Photocatalytic Synthesis of 2-Arylpyridines via Hantzsch Reaction under the Visible Irradiation and Oxygen Atmosphere
Rajakumar Ananthakrishnan and Sarifuddin Gazi

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