In this Catalysis Science & Technology PERSPECTIVE, David Glueck examines several examples of structure–selectivity relationships with the eventual goal of designing substrates for positive cooperativity and enhanced selectivity in asymmetric catalysis. This kind of systematic investigation hopefully is the way forward to rationally improve selectivity.
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Selectivity via catalyst or substrate control in catalytic asymmetric transformations of bifunctional symmetrical substrates
Catal. Sci. Technol., 2011, Advance Article
DOI: 10.1039/C1CY00048A, Perspective