This CrystEngComm Highlight provides a brief overview of advances in the synthesis of new pharmaceutical forms, based on molecular assembly through non-covalent interactions or coordination bonds which have been provided through mechanochemical methods of neat and liquid-assisted grinding. In particular, it has been shown that liquid-assisted grinding provides an environment free of solubility-based limitations inherent to solution-based cocrystallisation, thereby leading to highly efficient screening for polymorphs, cocrystals and salts. The applicability of liquid-assisted grinding and subsequently derived ion-and liquid-assisted grinding has been recently extended to the area of metal-based pharmaceuticals and metallodrugs. The work suggests mechanochemical screening may have a pivotal role in the future development of pharmaceutical solid forms and, potentially, in the covalent synthesis of drug candidates.
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The role of mechanochemistry and supramolecular design in the development of pharmaceutical materials
Amit Delori , Tomislav Friščić and William Jones
CrystEngComm, 2012, Advance Article