Three-dimensional multi-recognition flexible wearable sensor via graphene aerogel printing
Boxing An, Ying Ma, Wenbo Li, Meng Su, Fengyu Li and Yanlin Song
Chem. Commun., 2016, 52, 10948-10951
DOI: 10.1039/C6CC05910D, Communication
A new test, developed by investigators in China, exposes formaldehyde quickly and colourfully wherever it may be.
Formaldehyde is a carcinogenic pollutant produced mainly by industrial activity. It also occurs naturally in plants and animals, albeit only in small quantities. The simple aldehyde can be harmful in larger concentrations, but detecting it requires specialised equipment or applying harsh acids or bases.
Scientists from Japan can now transform an ionic liquid to a solid coordination polymer using UV light, and then reverse the switch using heat.
Tomoyuki Mochida and co-workers from Kobe University, Japan, synthesised a ruthenium-containing ionic liquid, which transforms to a yellow solid coordination polymer when irradiated with UV light. Applying heat reverses the process.
Scientists in France have created paper that can carry secret messages. In visible light, the paper is indistinguishable from regular paper and users can read, write or erase messages using three different wavelengths of UV light.
The functionalised paper, made by François-Xavier Felpin from the University of Nantes, and colleagues, contains coumarin molecules attached to the paper’s cellulose fibres. Exposing the paper to UV light with a wavelength of 340nm causes coumarin to react and create cyclobutane dimers. These dimers are invisible under visible light, but fluoresce under a UV lamp.
The 2015 Nobel Prize in Chemistry was jointly awarded to Tomas Lindahl, former director of Cancer Research UK’s Clare Hall Laboratories, Paul Modrich from Duke University in the US and Aziz Sancar from the University of North Carolina in the US for their “mechanistic studies of DNA repair”.
Tomas Lindahl, Paul Modrich and Aziz Sancar © Inserm-P. Latron, Mary Schwalm/AP/Press Association, Max Englund/UNC School of Medicine.
Tomas Lindahl’s research pieced together a molecular image of how base excision repairs DNA when a base of a nucleotide is damaged and subsequently managed to recreate the human repair process in vitro. The mechanism known as nucleotide excision repair, which excises damage from UV and carcinogenic substances, was then mapped by Aziz Sancar – the molecular details of this process changed the entire research field. Paul Modrich also studied the human version of the repair system. His work focused on DNA mismatch repair, a natural process which corrects mismatches that occur when DNA is copied during cell division.
The research carried out by the three 2015 Nobel Laureates in Chemistry has not only revolutionised our knowledge of how we function but also lead to the development of life – saving treatments. To celebrate these remarkable achievements, we are delighted to present a collection of recent Chemical Communications, Chemical Science and Chemical Society Reviews articles on DNA repair, FREE to read until 1 December 2015!
Finding needles in a basestack: recognition of mismatched base pairs in DNA by small molecules
Anton Granzhan, Naoko Kotera and Marie-Paule Teulade-Fichou
Chem. Soc. Rev., 2014, 43, 3630-3665
A label-free and sensitive fluorescent method for the detection of uracil-DNA glycosylase activity
Jing Tao, Panshu Song, Yusuke Sato, Seiichi Nishizawa, Norio Teramae, Aijun Tong and Yu Xiang
Chem. Commun., 2015, 51, 929-932
Researchers in Spain have come up with a way to track the biodistribution of a boron cluster complex used to prepare boron-carrier drugs for a prospective cancer treatment called boron neutron capture therapy (BNCT).
Drugs based on the boron cluster complex COSAN (cobaltabisdicarbollide) exploit the over-expression of membrane receptors in cancer cells to deliver therapeutic levels of 10B across the membrane. Although 10B is a stable isotope, when a beam of low-energy neutrons is applied to the cell, 10B captures a neutron and subsequently decays, releasing a high-energy α-particle and destroying the cell.
Read the original journal article in ChemComm – it’s free to access until 26th September:
COSAN as a molecular imaging platform: synthesis and “in vivo” imaging
Kiran B. Gona, Adnana Zaulet, Vanessa Gómez-Vallejo, Francesc Teixidor, Jordi Llop and Clara Viñas
Chem. Commun., 2014, Advance Article, DOI: 10.1039/C4CC05058D, Communication
We would like to celebrate our themed ChemComm collection Metal-Mediated Transformations of Small Molecules with our authors and community.
We invite you to submit your next communication article to ChemComm.
ISACS 14 Challenges in Organic Chemistry will bring together world leading experts in the field of organic chemistry and synthesis.
The best contribution will be awarded a fantastic prize from Chemistry World so don’t delay, be sure to submit your poster abstract by 2 June 2014.
For more information on how to submit your poster abstract please visit our conferences and events homepage.
The synthesis and characterization of a new class of photochromic metal-organic framework (MOF) linkers is described in this communication. Dinesh Patel from Pennsylvania State University and collaborators from the Benedict Research Group at University of Buffalo demonstrate that additional functionality, such as photoswitching, can be designed into a ligand without affections the topology of MOFs.
Compounds that change their molecular and electronic structure upon application of light are ideal candidates for sensors, switches and optical data storage medial. These photochromic molecules are now being pursued for use in MOFs in the hope of affording photonic control over the physical properties of the crystalline host. Several instances of MOFs containing non-covalently attached photochromic molecule have been reported, but there is a lack of control over guest orientation and concentration. The use of photoactive linkers means that the photochromic groups are covalently attached to the framework leading to MOFs with well-defined stoichiometry. In this report, a new class of photoswitchable linkers, based on diarylethene photochromes is introduced.
This article has been highlighted as a news story ‘metal organic frameworks react to light’ by Nina Notman in Materials Today
To read more about the full synthesis and characterization, including crystal structure analysis of reaction intermediates, download the full article for free*
Dinesh G. (Dan) Patel, Ian M. Walton, Jordan M. Cox, Cody J. Gleason, David R. Butzer and Jason B. Benedict
*Access is free untill the 19th May 2014 through a registered RSC account – click here to register
Researchers in China have disrupted the life cycle of the leading cause of cervical cancer – the human papilloma virus – using a macrocyclic molecule called a pillarene. The team hope their findings will offer new prophylactic avenues against the virus.There are over 100 different types of the human papilloma virus (HPV), 40 of which can be sexually transmitted. Most infections are symptomless and do not result in disease. However, a few types of the virus are known to cause changes in cells that can lead to cervical and throat cancer. HPV types 16 and 18 cause 70% of cervical cancer cases.
Vaccination programmes against types 16 and 18 have recently become available to teenage girls in some countries. However, as one of the lead scientists on the pillarene project Ying-Wei Yang at Jilin University, China, explains, there is an urgent need for alternatives: ‘the current HPV vaccines are type-specific, expensive and require cold chain transportation, so are not very helpful, especially in developing countries where most cervical cancers occur.’
HPV is made up of two proteins, L1 and L2. These assemble into pentamers to form the virus particles that then attach to cells, resulting in infection. Some researchers believe that disrupting the assembly of the virus using molecules that bind to these two proteins might be the key to stopping it in its tracks.
CP5A, a carboxylatopillararene sodium salt, has a 3D, rigid and π-rich cavity that binds to amino acids
The team hope to screen other small molecules to find inhibitors for more specific binding sites on the interface between L1 and L2. Their long term aim is to use one of these to produce a HPV vaccine.
Margaret Stanley, a leading expert on the life cycle of human papilloma viruses at the University of Cambridge in the UK sees this study as valuable research for investigations on viral assembly. However, she cautions that the therapeutic value of these approaches is not clear. ‘Inhibiting viral assembly will significantly block transmission, but will not necessarily have any effect on infection level since viral genomes will still be present and potentially able to reactivate after the end of any treatment with inhibitors.’
Read the original journal article in ChemComm – it’s free to download until 28th March:
Efficient inhibition of human papillomavirus 16 L1 pentamer formation by a carboxylatopillarene and a p-sulfonatocalixarene
Dong-Dong Zheng, Ding-Yi Fu, Yuqing Wu, Yu-Long Sun, Li-Li Tan, Ting Zhou, Shi-Qi Ma, Xiao Zha and Ying-Wei Yang
Chem. Commun., 2014, Advance Article, DOI: 10.1039/C3CC49789E