The hydrogel successfully mimiced porcine gastric mucosa in mucoadhesion testing experiments
Scientists in the UK have made a synthetic surface that could replace animal tissues in liquid drug formulation tests.
‘Mucosal membranes like those in the nasal cavity, mouth, eyes, stomach, bladder and vagina are continuously being washed with biological fluids. The majority of drugs administered to these surfaces will get washed away, reducing drug absorption and efficiency of any therapy,’ explains Vitaliy Khutoryanskiy, from the University of Reading, who led the work. Read the full article in Chemistry World»
Read the original journal article in ChemComm – it’s open access:
Novel glycopolymer hydrogels as mucosa-mimetic materials to reduce animal testing
Michael T. Cook, Sarah L. Smith and Vitaliy V. Khutoryanskiy
Chem. Commun., 2015, Advance Article
DOI: 10.1039/C5CC02428E, Communication
