FREE Medicinal Chemistry Toolkit App: Easy to access functions – anytime, anywhere

The Medicinal Chemistry Toolkit App, compatible with iOS devices and optimised for iPad, provides a suite of resources to support the day to day work of a medicinal chemist.

Search the App store for “Medicinal Chemistry Toolkit.”

Download our Medicinal Chemistry Toolkit App on the AppStore

Functions include:

  • Cheng-Prusoff calculator
  • Dose to man calculator
  • Gibbs free energy to binding constant calculator
  • Maximum absorbable dose calculator
  • Potency shift due to plasma protein binding calculator
  • LogD vs pH curves
  • Attrition modeller
  • Drug-drug interaction modeller

Exciting new functionality recently released in v2.0 allows you to draw your own structures and provides direct feedback on the quality or drug-like nature of your compound and calculates pharmacologically relevant properties (GClogP, ligand efficiency).

The Handbook of Medicinal Chemistry

The app has been designed in collaboration with the editors of The Handbook of Medicinal Chemistry: Principles and Practice, which was published in December 2014 providing a comprehensive, everyday resource for a practicing medicinal chemist throughout the drug development process.

Price: £84.99 – RSC Members receive 35% discount!
Order Now.
Print ISBN: 978-1-84973-625-1
Pages:  788

Comprehensive and up-to-date information covering the entire drug development process.

Written and edited by experts from academia and industry.
Case studies with hints and tips from within the industry allow medicinal chemists to apply academic understanding to drug discovery.

Coming Soon:  interactive electronic format

The Handbook will be published online to allow greater linking to relevant resources. Per chapter download from our publication platform containing additional features, such as links to protein and chemical structures, interactive graphs and downloadable project management templates, will be available soon.

PDF eISBN: 978-1-78262-183-6
EPUB eISBN: 978-1-78262-419-6
DOI: 10.1039/9781782621836

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New solar energy books from the Royal Society of Chemistry

Take a look at these recently published books on solar energy in our Energy and Environment Series by clicking on the links below. You can access the front matter, table of contents and the first chapter of these eBooks for free.

Solar Energy Conversion edited by Piotr Piotrowiak Solar Energy Conversion

This book provides a state-of-the art review on the experimental and theoretical approaches of studying interfacial electron and excitation transfer processes which are crucial to solar energy conversion. The presented approach is fundamental in nature and thus applicable to a broad range of hybrid photovoltaic and photocatalytic materials and interfaces. The book focuses on the dynamic aspects of the electron injection, exciton and carrier relaxation processes, as well as coherence effects, which continue to provide the impetus and the greatest challenge for the development of new methodologies.

Edited and written by leading experts in the field, “Solar Energy Conversion” will appeal to those working on the fundamentals of hybrid photovoltaic and photocatalytic materials, as well as those commercially interested in their applications.

Materials Challenges edited by Stuart J. C. Irvine  Book cover: Materials Challenges

This book provides an authoritative reference on the various aspects of materials science that will impact the next generation of photovoltaic module technology.  The emphasis of the book is on thin film photovoltaic materials, addressing the fundamental aspects of photovoltaic solar cell materials and giving a comprehensive description of each, either in research or in production. Particular attention is given to the key materials drivers of solar conversion efficiency, long term stability, materials costs and materials sustainability.

 The book is essential reading for materials scientists, energy technologists and all those involved in solid-state physics.

Advanced Concepts in Photovoltaics edited by Arthur J.  Nozik, Gavin Conibeer, Matthew C.  Beard  Book cover: Advanced Concepts in Photovoltaics

This book presents the latest developments in photovoltaics which seek to either reach or surpass the Shockley-Queisser limit, and to lower the cell cost per unit area. Progress toward this ultimate goal is presented for the three generations of photovoltaic cells. The first generation is based on crystalline silicon semiconductors. The second generation is based on thin film silicon, compound semiconductors, amorphous silicon and various mesoscopic structures. The third generation is based on the unique properties of nanoscale materials, new inorganic and organic photoconversion materials, highly efficient multi-junction cells and novel photovoltaic processes. The extent to which photovoltaic materials and processes can meet the expectations of efficient and cost effective solar energy conversion to electricity is discussed.

Written by an international team of expert contributors, and with researchers in academia, national research laboratories, and industry in mind, this book is a comprehensive guide to recent progress in photovoltaics and essential for any library or laboratory in the field.

Did you know?

You can now keep up-to-date with the latest books published from the Royal Society of Chemistry with our eBook Table of Content Email Alerts. Sign up today by selecting RSC eBook Collection in the Book Alerts section on the Email Alerts Service Form.

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New materials books from the Royal Society of Chemistry

Take a look at these recently published Materials Science books covering topics across a number of our portfolio series by clicking on the links below. You can access the front matter, table of contents and the first chapter of these eBooks for free.

New in the RSC Smart Materials Series

Semiconductor Nanowires  edited by Wei Lu and Jie Xiang Semiconductor Nanowires

This book provides a timely reference on semiconductor nanowires including an introduction to their synthesis and properties. Chapters focus on the different applications including photovoltaics, nanogenerators, transistors, biosensors and photonics.

Edited by leading experts in the field and with contributions from well-known scientists, the book will appeal to both those working on fundamental nanomaterial research and those commercially interested in their applications.

Cationic Polymers in Regenerative Medicine edited by Sangram K. Samal and Peter Dubruel Cationic Polymers in Regenerative Medicine

This book brings together the expertise of leading experts in the field to provide a comprehensive overview of the recent advances in cationic polymer synthesis, modification and the design of biomaterials with different structures for therapeutic applications. Applications discussed in the book include drug and gene delivery, therapeutics in thrombosis and inflammation as well as gene therapy.

Suitable both for an educational perspective for those new to the field and those already active in the field, the book will appeal for postgraduates and researchers. The broad aspects of the topics covered are suitable for polymer chemists interested in the fundamentals of the materials systems as well as pharmaceutical chemists, bioengineering and medical professionals interested in their applications.

New in the RSC Soft Matter Series

Particle-Stabilized Emulsions and Colloids edited by To Ngai and Stefan Bon  Particle-Stabilized Emulsions and Colloids

In many cases of colloidal particles at interfaces, the mechanism of particle interactions is still unknown. This book introduces the basic concepts and principles of colloidal particles at liquid-liquid interfaces,  discusses the latest advances in emulsions stabilized by solid and soft particles and covers applications in food science and oil extraction.

With contributions from leading experts in these fields, this book will provide a background to academic researchers, engineers, and graduate students in chemistry, physics and materials science. The commercial aspects will also be of interest to those working in the cosmetics, food and oil industry.

New in the RSC Polymer Chemistry Series

Glycopolymer Code edited by C. Remzy Becer and Laura Hartmann Glycopolymer Code

Glycopolymers are important for cell signalling, recognition pathways, and their role in the immune system. They are gaining attention for new applications in tissue engineering and drug delivery. This book discusses the preparation, characterization and applications of glycopolymers providing a complete overview of the topic with examples from the latest research

With contributions from leading researchers in the field, the book is a unique source for graduates and academics new to the subject and already working in the area of glycopolymers.

New in the RSC Nanoscience and Nanotechnology Series

Microfluidics for Medical Applications edited by Albert van den Berg and Loes Segerink Microfluidics for Medical Applications

Lab-on-a-chip devices for point of care diagnostics have been present in clinics for several years now. Alongside their continual development, research is underway to bring the organs and tissue on-a-chip to the patient, amongst other medical applications of microfluidics.

This book provides the reader with a comprehensive review of the latest developments in the application of microfluidics to medicine. Written with students and practitioners in mind, and with contributions from the leaders in the field across the globe, this book provides a complete digest of the state-of-the-art in microfluidics medical devices and will provide a handy resource for any laboratory or clinic involved in the development or application of such devices.

Announcing

 

Structured Soft and Biological Matter, 9 June 2015, Durham UK

This one-day meeting, co-organised by the Royal Society of Chemistry journal Soft Matter and the Durham Centre for Soft Matter, Durham University, UK, will mark the 10th anniversary of the launch of Soft Matter. For more information, please click here.

Did you know?

You can now keep up-to-date with the latest books published from the Royal Society of Chemistry with our eBook Table of Content Email Alerts. Sign up today by selecting RSC eBook Collection in the Book Alerts section on the Email Alerts Service Form.

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Royal Society of Chemistry online Bookshop relaunch

Our new, streamlined online Bookshop will very soon go live! Its many novel features make browsing our vast collection of print and eBooks much easier and faster, allowing you to stay up to date with the most recent cutting-edge discoveries and developments in the chemical sciences.

  • The Bookshop homepage showcases our selected new publications, forthcoming publications and highlights, with their prices and cover images, to save you time if you’re looking for a specific item.
  • Should you be in the mood to browse and don’t have a particular book in mind already, you can search through both our published and forthcoming books, accumulating filters to pinpoint exactly the topics you are interested in. We also have a counter which ticks over with every filter that you add, to show how many books are available with your search terms.
  • Are you a Bookseller or Author? The Bookshop has tabs packed with useful information relevant to you regarding catalogues, E-Alerts, promotional material, publishing guidelines and recent reviews.
  • If you’re stuck for present ideas, the Bookshop also contains a whole tab dedicated to Gift suggestions.
  • Our Add to Basket and Checkout procedures are much more straightforward, so you can buy what you want when you want. Perfect for our busy clients. You can also pre-order forthcoming books to ensure you don’t miss out on the most popular titles.

So keep an eye out for our fresh new page. We hope you enjoy your shopping experience with us.

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First Zing Computational Chemical Biology Conference, 6th-9th August 2015

The first Zing Computational Chemical Biology conference will take place from the 6th to the 9th of August 2015. It will bring together scientists to discuss multidisciplinary research that leverages computer simulation to address key questions crossing the physical sciences-life sciences/biomedical interface. In particular, the conference will feature sessions focusing on the development and application of novel and state-of-the-art computational tools and technology for solving major problems in the life and biomedical sciences.

Topics will include advances in molecular dynamics simulation of enzymes; computational approaches to studying the interaction of drugs, drug transporters and signalling enzymes with lipid membranes; simulation of protein-protein interaction and multi-protein complex enzymatic systems; computational study of signalling pathways; new techniques in computational drug discovery as they apply to enzyme reactivity and dynamics; simulation of allosteric interactions; advances in multi-scale modelling; new techniques for direct simulation of reactivity in biological systems; and the impact of technological advances in computer hardware and software on the field of chemical biology.

The conference will feature lectures by established leaders in the fields, as well as encouraging young and talented researchers to present both challenging questions and new ideas for solving them. The aim is to encourage a collegial atmosphere to promote stimulating and insightful discussion while enjoying the beauty of tropical Cairns, Australia.

To see a full list of confirmed speakers, click here.


Deadlines:

Talk Consideration Deadline: 1st May 2015

Poster Submission Deadline: 1st June 2015


URL: http://www.zingconferences.com/conferences/computational-chemical-biology/

Computational Chemical Biology Conference 2015, Cairn, Australia

The first Computational Chemical Biology Conference will take place from the 6th to the 9th of August 2015 in Cairn, Australia

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RSC Books at Society of Toxicology Expo

Come and meet us at the SOT Annual Meeting Expo in San Diego from March 22–26th (booth #2143)!

Email us if you are attending and would like to arrange a meeting.

We will have a range of textbooks, books from the Issues in Toxicology Series and other titles on display and for you to browse and purchase at a 30% discount. Rowan Frame, Books Commissioning Editor, and Jen Griffiths, Editorial Development Manager, will be on hand to answer your questions about books, Toxicology Research, and other journals.


Toxicology Research have collated some of their hottest papers.

These papers are free to access until 31st March – we do hope that you enjoy reading them. Click here to see the collection.


Recently published books in the Issues in Toxicology Series:

You can read the first chapter for free through your Personal RSC Publishing Account

Manganese in Health and Disease Manganese in Health and Disease
Lucio Costa (Editor), Michael Aschner (Editor), ISBN: 978-1-84973-943-6

The book comprehensively covers the toxicology of manganese. Leading investigators provide perspectives from toxicology, neuroscience, nutrition, molecular biology and risk assessment disciplines and  chapters cover  the toxicokinetics, toxicodynamic interactions and health effects of manganese, as well as its potential role in neurodegenerative diseases.


Metabolic Profiling: Disease and Xenobiotics
Martin Grootveld (Editor)

Multivariate analysis of the multi-component analytical profiles of carefully collected biofluid and/or tissue biopsy specimens can provide a ‘fingerprint’ of their biomolecular/metabolic status. This exemplary new book highlights applications of these techniques in the areas of drug therapy and toxicology, cancer, obesity and diabetes, as well as outlining applications to

cardiovascular, infectious, inflammatory and oral diseases in detail.

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Take 1 minute… and vote now!

We challenged early career researchers to explain the importance of chemistry to human health in just 1 minute. The shortlisted videos are now online and we want you to pick your favourite entry.

The chemical sciences will be fundamental in helping us meet the healthcare challenges of the future, and we are committed to ensuring that they contribute to their full potential. As part of our work in this area, we invited undergraduate and PhD students, post-docs and early career researchers to produce an original video that demonstrates the importance of chemistry in health.

We were looking for imaginative ways of showcasing how chemistry helps us address healthcare challenges and entries could be no more than 1 minute long.

The winner will receive a £500 cash prize, with a £250 prize for second place and £150 prize for third place up for grabs too.

Want to get involved? Watch our 6 shortlisted videos and vote for your favourite before 11.59pm (GMT) 17 April 2015!

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New materials books from the Royal Society of Chemistry

Take a look at these recently published Materials Science books covering topics across a number of our portfolio series by clicking on the links below. You can access the front matter, table of contents and the first chapter of these eBooks for free.

New in the RSC Smart Materials Series

Book cover: Semiconductor NanowiresSemiconductor Nanowires edited by Wei Lu and Jie Xiang

This book provides a timely reference on semiconductor nanowires including an introduction to their synthesis and properties and specific chapters focusing on the different applications including photovoltaics, nanogenerators, transistors, biosensors and photonics. This is the first book dedicated to Semiconductor Nanowires and provides an invaluable resource for researchers already working in the area as well as those new to the field.

Edited by leading experts in the field and with contributions from well-known scientists, the book will appeal to both those working on fundamental nanomaterial research and those commercially interested in their applications.

Book cover: Photocured MaterialsPhotocured Materials edited by Atul Tiwari and Alexander Polykarpov

The materials technologies based on photocuring are gaining momentum, and this will be the first book to provide an in-depth focus on the subject. This book summarises the fundamentals required to understand the field, characterises the use of novel materials and the development of synthetic aspects, and discusses the future of the technology.

The comprehensive review chapters are suitable for a broad readership from diverse backgrounds including chemistry, physics, materials science and engineering, medical science, pharmacy, biotechnology and biomedical engineering. Photocured Materials will be of interest to students, researchers, scientists, engineers and professors.

New in the RSC Soft Matter Series

Book cover: Particle-Stabilized Emulsions and ColloidsParticle-Stabilized Emulsions and Colloids edited by To Ngai and Stefan Bon

In many cases of colloidal particles at interfaces, the mechanism of particle interactions is still unknown. Particle-Stabilized Emulsions and Colloids looks at recent studies on the behaviour of particles at liquid interfaces. The book first introduces the basic concepts and principles of colloidal particles at liquid-liquid interfaces including the interactions and conformations. The book then discusses the latest advances in emulsions and bicontinuous emulsions stabilized by both solid and soft particles and finally the book covers applications in food science and oil extraction.

With contributions from leading experts in these fields, this book will provide a background to academic researchers, engineers, and graduate students in chemistry, physics and materials science. The commercial aspects will also be of interest to those working in the cosmetics, food and oil industry.

Hydrogels in Cell-Based Therapies edited by Che J Connon  and Ian W Hamley

Book cover: Hydrogels in Cell-Based TherapiesThis book looks at the use of different polymers and other bionanomaterials to fabricate different hydrogel systems and their biomedical applications including enzyme responsive hydrogels and biomaterials, thermally responsive hydrogels, collagen gels and alginates.

With complementary expertise in cell biology and soft materials, the Editors provide a comprehensive overview of recent updates in this extremely topical field. This highly interdisciplinary subject will appeal to researchers in cell biology, biochemistry, biomaterials and polymer science and those interested in hydrogel applications.

New in the RSC Polymer Chemistry Series

Book cover: Cationic Polymers in Regenerative MedicineCationic Polymers in Regenerative Medicine edited by Sangram K. Samal and Peter Dubruel

This book brings together the expertise of leading experts in the field to provide a comprehensive overview of the recent advances in cationic polymer synthesis, modification and the design of biomaterials with different structures for therapeutic applications. Chapters cover recent developments in novel cationic polymer based systems including poly(L-lysine), Poly(N,N-dimethylaminoethyl methacrylate)  and cationic triazine dendrimers as well as cationic polymer-coated micro- and nanoparticles and cationic cellulose and chitin nanocrystals. Applications discussed in the book include drug and gene delivery, therapeutics in thrombosis and inflammation as well as gene therapy.

Suitable both for an educational perspective for those new to the field and those already active in the field, the book will appeal for postgraduates and researchers. The broad aspects of the topics covered are suitable for polymer chemists interested in the fundamentals of the materials systems as well as pharmaceutical chemists, bioengineering and medical professionals interested in their applications.

Did you know?

You can now keep up-to-date with the latest books published from the Royal Society of Chemistry with our eBook Table of Content Email Alerts. Sign up today by selecting RSC eBook Collection in the Book Alerts section on the Email Alerts Service Form.

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Chemistry World review-Science and Art: the Painted Surface

At the tail end of last year we received this positive and perceptive review of ‘Science and art: the painted surface’ from Catherine Emma Nicholson at Chemistry World. This book was Edited by Antonio Sgamellotti, Brunetto Giovanni Brunetti and Costanza Miliani. If it inspires you to find out more about this publication, then further details can be found from our online bookshop.


We hope you enjoy reading this review article, and that you enjoy reading the book itself even more!



“This volume shows a global solution to a long-discussed problem: how to get scientists, art historians and conservators working together. The book presents a host of projects where collaboration has allowed all of these groups to learn from one another. Some chapters describe the science and techniques, useful for scientists wishing to work in a similar setting; others focus on the art, showing how the results of scientific studies have led to a deeper understanding of a corpus of artifacts, linking to particular cultural traditions. Unsurprisingly, given the editorial board of the book, Science and art gives the reader an overview of the diverse range of projects that Charisma (cultural heritage advanced research, a multidisciplinary conservation and restoration project) researchers have been involved with. The book shows a number of analytical techniques that are now becoming essential in conservation science. Charisma researchers, along with other scientific experts, used their expertise to reveal hidden depths in many famous works. The book discusses various techniques, focusing on non-invasive methods such as infrared reflectance, Raman spectroscopy, x-ray fluorescence and multispectral imaging as well as the more exotic synchrotron x- ray analysis. Science and art also provides an excellent read for art historians, who will instantly recognise the famous pieces that have been studied, while giving them insight into how a painting was constructed, what it is made from, or how the colours would have looked when they were freshly painted. I was struck by the editors’ choice not to only focus on European works, but to take a worldwide view, including chapters on Mayan manuscripts, Tibetan paintings and Japanese panels. This clearly shows that this blossoming research area requires even more bridges to be built, spanning research communities and forging stronger links between them.”

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Metals in Health collection

Take a look at our publications surrounding metals in health. These particular books are taken from across several of our series and complement each other well. This is just a snapshot of the books which are currently available and so if you can’t find what you need then we would recommend visiting our online bookshop in order to find other similar titles.

Manganese in Health and Disease

Lucio Costa (Editor), Michael Aschner (Editor)

RSC Issues in Toxicology series

Manganese in the diet is nutritionally essential for normal physiologic functioning. However, excessive exposure to manganese has been associated with developmental, neurodegenerative and other disorders. The book comprehensively covers the toxicology of manganese. Leading investigators provide perspectives from toxicology, neuroscience, nutrition, molecular biology and risk assessment disciplines and chapters cover the toxicokinetics, toxicodynamic interactions and health effects of manganese, as well as its potential role in neurodegenerative diseases. A large section devoted to health effects presents the latest research that associates manganese exposure to potential human diseases. Any scientists, health professional or regulator involved with metal exposure and toxicology should find this volume essential reading. Students and researchers in neurotoxicology will also find this book a useful reference.

The Carcinogenicity of Metals

Human risk through occupational and environmental exposure

Alan B. G. Lansdown (Author)

RSC Issues in Toxicology series

This book re-evaluates epidemiological and occupational health studies, experimental studies in animals and in vitro experiments relating to the toxicity of 27 metal and metalloid elements for which evidence of carcinogenicity has been presented. Human carcinogenic risk is substantiated in relation to arsenic, beryllium, thorium, chromium, radioactive elements, probably lead, and some nickel and cobalt compounds, and respirable silica particles, but the carcinogenicity of iron, aluminium, titanium, tungsten, antimony, bismuth, mercury, precious metals, and certain related compounds in humans is unresolved. The toxicity and carcinogenicity of each element is specific but correlates poorly with its position in the Periodic Table. Carcinogenicity differs according to the valency of the ion and its ability to interact with and penetrate membranes in target cells  and to bind, denature or induce mutations by genotoxic or epigenetic mechanisms. This important text comprehensively examineseach of the elements providing detailed information on the carcinogenicity and toxicity and detailing the most up-to-date research in this area. The book will be an essential tool for toxicologists, medicinal and biochemists, and environmental scientists working in both industry and academia.


Heavy Metals In Water

Presence, Removal and Safety

Sanjay Sharma (Editor)

Contamination of drinking water is a worldwide problem, and ongoing work is taking place across the globe to address the issues affecting this precious commodity. Focussing on the presence of heavy metals in water, this book addresses the opportunities and challenges of this important area of research. Written and edited by experts working within the area the book highlights new techniques and research methodologies used to treat the widespread issue of dissolved heavy metals in drinking water supplies. The text covers a wide range of topics, including biofilterations, use of nanotechnology against heavy metals, removal of heavy metals using industrial and agricultural waste, use of surfactants, soil degradation and removal of dyes and pigments from industrial effluents. Providing an up-to-date treatise on this developing field, this text will be essential reading for water and environmental scientists, toxicologists, biochemists and regulators, and anyone interested in the treatment and decontamination of the World’s drinking water supplies.

Binding, Transport and Storage of Metal Ions in Biological Cells

Wolfgang Maret (Editor), Anthony Wedd (Editor)

RSC Metallobiology series

Metal ions play key roles in biology. Many are essential for catalysis, for electron transfer and for the fixation, sensing, and metabolism of gases. Others compete with those essential metal ions or have toxic or pharmacological effects. This book is structured around the periodic table and focuses on the control of metal ions in cells. It addresses the molecular aspects of binding, transport and storage that ensure balanced levels of the essential elements. Organisms have also developed mechanisms to deal with the non-essential metal ions. However, through new uses and manufacturing processes, organisms are increasingly exposed to changing levels of both essential and non-essential ions in new chemical forms. They may not have developed defenses against some of these forms (such as nanoparticles). Many diseases such as cancer, diabetes and neurodegeneration are associated with metal ion imbalance. There may be a deficiency of the essential metals, overload of either essential or non-essential metals or perturbation of the overall natural balance. This book is the first to comprehensively survey the molecular nature of the overall natural balance of metal ions in nutrition, toxicology and pharmacology. It is written as an introduction to research for students and researchers in academia and industry and begins with a chapter by Professor R J P Williams FRS.

Mechanisms and Metal Involvement in Neurodegenerative Diseases

Roberta Ward (Editor), Robert Crichton (Editor), David Dexter (Editor)

RSC Metallobiology series

Dementia and neurodegenerative diseases such as Parkinson’s and Alzheimer’s are becoming an increasingly important cause of medical and social concern due to the growth in the ageing population. Mechanisms and Metal Involvement in Neurodegenerative Diseases delivers in one volume a streamlined source of information on each of the main neurodegenerative diseases including mild cognitive impairment, Parkinson’s, Alzheimer’s, Freiderich’s ataxia, prion disease, multiple sclerosis and alcoholic brain damage. Each chapter is structured to give the definition of disease, proteins involved with structure of normal protein and abnormal proteins, pathology associated with the abnormal proteins, oxidative stress and inflammation, iron homeostatic mechanisms, primary neurotransmitter involved, other metal involvement and therapeutic strategies. Structures of the adherent protein involved in the disease process are also presented with emphasis on the chemical structures used in the treatment of each neurodegenerative disease together with their biochemical mode of action. Written by acknowledged experts in their respective areas this new book provides readers with readily accessible information on each of the neurodegenerative diseases.

Silver in Healthcare

Alan B. G. Lansdown (Author)

RSC Issues in Toxicology series

Silver in healthcare has many different facets and since the early concepts of microbiology of the 1880’s, has been developed from usage in surgical clips, staples, foil wound dressings and surgical implants, to the widespread and clinically effective antiseptic wound dressings, sutures, catheters, bone and dental implants, and cardiovascular devices of today. From the dawn of human civilisation, silver has had a role of water purification and even now has a role in hospital water systems for control of MRSA and legionnaires disease. Biotechnological advances in recent years have extended the antimicrobial properties of silver into production of hygiene textiles and use in domestic products. Important advances have been made in understanding mechanisms of antimicrobial action of silver, the central importance of ionisation patterns in the presence of body fluids and secretion, and the genetical and molecular profiles of silver resistance. This publication is a comprehensive account of the history of silver in medicine, its clinical benefits and wide advantages as a broad spectrum antimicrobial agent. It is clear from the extensive array of publications in recognised and unofficial press, that many misconceptions and misleading conceptions have been perpetuated, leading to errors in evaluation of the safety of the metal in occupational, domestic and therapeutic situations. The book is unique in that it is the only comprehensive presentation of the toxicology of silver and it identifies the major misconceptions in the safety of silver and interpretation of argyria and argyrosis as central features of silver toxicity. In this book, Dr Lansdown reviews the literature from a clinical and experimental viewpoint, with the benefit of his many years research on silver and experience gained in working with clinicians, healthcare product manufacturers and microbiologists. There is also discussion in the book on the relevance of antimicrobial resistance to silver and deficiencies in present day clinical practice in not evaluating incidences of resistance on a routine basis. The subject matter is presented in a readable fashion and includes reference to use of the metal in such practices as acupuncture and treatment of tropical diseases as practised in some parts of the world, each of which is accompanied by special clinical risk. It is also a collation of current views on the use and efficacy of silver as a broad spectrum antibiotic. The chapters which deal specifically with toxicological aspects of silver in clinical, occupational and environmental issues are central to the book’s value. The book is aimed at clinicians, research scientists and product manufacturers and will provide ideas for new research and academic endeavour. It is also essential reading for research students with an interest in metal toxicity and its management in mammalian tissues.

Chemistry, Applications and Environmental Impact

L F Kozin (Author), Steve C Hansen (Author)

Mercury has many applications in scientific research and industry from amalgams for dental restoration to light bulbs. Developed from a combination of material originally published in Russian and the authors’ research knowledge, this book provides a comprehensive treatise on the chemistry and metallurgy of amalgams. Coverage includes analysis, physico-chemical properties, electrochemistry, purification, inorganic and organic mercury chemistry, industrial application and synthesis and environmental aspects of mercury. This book provides a thorough understanding of amalgam metallurgy which is essential for academics, industrialists and postgraduates working in relevant fields. Guaranteed to bring a wealth of information, this book will be a welcome addition to the literature.


Is Arsenic an Aphrodisiac?

The Sociochemistry of an Element

William R Cullen (Author)

Sex, drugs, rocks, gold, murder, war, mass poisonings, the deaths of Napoleon, Tchaikovsky, Mozart, and others are all linked by one element – arsenic! Arsenic has been around since the beginning of time and the word has become a metaphor for poison with associated shock value. The general public are fearful of any possible exposure to it and yet it holds a certain dark and eerie fascination! The average person has only one idea about arsenic – it is poison – and this reputation has a sound base. Some arsenic compounds are very toxic and have been used with criminal intent from the time of the ancient Romans to the present day. Up until now, there has been no book that covers arsenic with such breadth. This book is a general appreciation of how much the element, arsenic, has become part of our lives in an entertaining style covering the years 1000 BC to the present day. The coverage of the chemistry, toxicology, and medicinal aspects is deliberately kept at a level for the general reader to understand. It covers the way in which this ubiquitous element and its compounds have influenced the lives of the people of the world. The author’s objective in writing this book was not to elaborate on the vast chemistry of the element, but to try to reveal to the general reader how the element and its compounds have become embedded in our social fabric, for good and for ill. No other element comes close in this regard and he uses the word sociochemistry to describe this interface between society and chemistry. The book covers a broad range of topics including the use of arsenic in human medicine in many cultures from Chinese medicine to the beginning of chemotherapy. This peaked in the western world in the early 20th century, with Ehrlich’s discovery of salvarsan, an arsenic-based cure for syphilis that gave rise to the field of chemotherapy. Salvarsan and related compounds were eventually displaced by antibiotics such as penicillin. Arsenic trioxide has staged a comeback, however, and is being used as a successful treatment for a form of leukemia. Other chapters cover arsenic compounds which were widely used in agriculture and wood preservation during the 20th century and their associated myths as well as arsenic compounds as chemical warfare agents and the resulting stockpile. The topic of arsenic in the environment is discussed in depth – arsenic is all around us – in our soil, our water, and our food, and our bodies have adapted to its presence and it does not usually pose a problem. However, the natural presence of high concentrations of arsenic in drinking water currently threatens the lives of millions of people in India, Bangladesh, Mexico and elsewhere. It also covers mining and pesticide manufacturing which can lead to high local arsenic concentrations in soils, slag heaps and mine tailings which, when located close to human activities, can produce human health risks. Other chapters cover a variety of topics including: ” A proposed connection between arsenic and Cot Death (SIDS) which caused panic ” The high concentration of arsenic in kelp products-is this harmful? ” What about the 237,000 tonnes of arsenic trioxide stored in a mine in Canada? ” How toxic is arsenic anyway, and how do you assess the risks of exposure? ” How did Napoleon die? These and many other topics are addressed at a level that will result in understanding without delving into too much technical detail or requiring a degree in chemistry. Essential reading for everyone with a general interest in science, this illuminating text covers a broad range of topics.


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