Archive for the ‘Hot Article’ Category

HOT articles in Analytical Methods

Take a look at our new hot articles just published in Analytical Methods. These papers are all free to read until 8th April 2014. Enjoy the reading! Graphical abstract: Selective and colorimetric detection of pyruvic acid using conformational switch of i-motif DNA and unmodified gold nanoparticles

Sensitive and rapid determination of diethylstilbestrol using mesoporous SBA-15 modified electrode
Xiafeng Xie, Dong Sun, Guishen Liu and Qingpeng Zeng
Anal. Methods, 2014,6, 1640-1644
DOI: 10.1039/C3AY41977K, Paper

Locating microcalcifications in breast histopathology sections using micro CT and XRF mapping
Robert Scott, Catherine Kendall, Nicholas Stone and Keith Rogers
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C3AY42158A, Paper

Spatially resolved chemical imaging of individual atmospheric particles using nanoscale imaging mass spectrometry: insight into particle origin and chemistry
Sutapa Ghosal, Peter K. Weber and Alexander Laskin
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C3AY42012D, Paper Graphical abstract: Preparation of a mixed-mode silica-based sorbent by click reaction and its application in the determination of primary aromatic amines in environmental water samples

Selective and colorimetric detection of pyruvic acid using conformational switch of i-motif DNA and unmodified gold nanoparticles
Wei Li, Chao Pan, Ting Hou, Xiuzhong Wang and Feng Li
Anal. Methods, 2014,6, 1645-1649
DOI: 10.1039/C3AY41883A, Paper

Preparation of a mixed-mode silica-based sorbent by click reaction and its application in the determination of primary aromatic amines in environmental water samples
Yuling Zhu, Weiya Zhang, Lixia Li, Caiying Wu and Jun Xing
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C3AY42027B, Paper

Microfluidic chip for rapid analysis of cerebrospinal fluid infected with Staphylococcus aureus
Hao Yuan, Yingchao Liu, Xiran Jiang, Shangchen Xu and Guodong Sui
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C3AY41925H, Communication Graphical abstract: Brushing, a simple way to fabricate SERS active paper substrates

Brushing, a simple way to fabricate SERS active paper substrates
Wei Zhang, Bowei Li, Lingxin Chen, Yunqing Wang, Dingxue Gao, Xuehua Ma and Aiguo Wu
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C4AY00046C, Paper

Quantification of recombinant human relaxin-2 (B-29/A-24) in non-pregnant rat plasma using ultra performance liquid chromatography-mass spectrometry
Xiaoyan Zhu, Jingjing Liu, Jie Wu, Rongyue Cao and Taiming Li
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C3AY42194E, Paper

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HOT articles in Analytical Methods

Take a look at our new hot articles just published in Analytical Methods. These papers are all free to read until March 31st 2014. Enjoy the reading!

Graphical abstract: Human papilloma virus genotyping by surface-enhanced Raman scattering

Human papilloma virus genotyping by surface-enhanced Raman scattering
Sam Hibbitts, P. Lewis White, Julie Green, Graeme McNay, Duncan Graham and Ross Stevenson
Anal. Methods, 2014,6, 1288-1290
DOI: 10.1039/C4AY00155A, Communication

A porous layer open tubular monolith on microstructured optical fibre for microextraction and online GC-MS applications
Samuel M. Mugo, Lauren Huybregts and James Mazurok
Anal. Methods, 2014,6, 1291-1295
DOI: 10.1039/C3AY41732H, Communication

Simple and highly sensitive electrogenerated chemiluminescence adenosine aptasensor formed by adsorbing a ruthenium complex-tagged aptamer on single-walled carbon nanotubes
Zhejian Li, Honglan Qi, Haiying Yang, Qiang Gao and Chengxiao Zhang
Anal. Methods, 2014,6, 1317-1323
DOI: 10.1039/C3AY41978A, Paper

Spectroscopic studies on naftazone and its metal complexes with analytical applications for quality control of tablets
Fawzia Ahmed Ibrahim, Nahed Mahmoud El-Enany, Rania Nabih El-Shaheny and Ibraam Emad Mikhail Graphical abstract: Simple and highly sensitive electrogenerated chemiluminescence adenosine aptasensor formed by adsorbing a ruthenium complex-tagged aptamer on single-walled carbon nanotubes
Journal Article
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C3AY41819G, Paper

Determination of the migration of eight parabens from antibacterial plastic packaging by liquid chromatography-electrospray ionization-tandem mass spectrometry
Lijun Lu, Wenming Xiong, Xiaojing Li, Shuiyuan Lv, Xi Tang, Minshi Chen, Zhexiang Zou, Zhenyu Lin, Bin Qiu and Guonan Chen
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C3AY42080A, Paper

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Improving brain cancer diagnostics with Raman spectroscopy

Microscopic images of H&E stained tissue sections of normal brain, metastatic brain, primary sites and GBM brain WHO grade IV (x100).

According to the Brain Research Trust, brain tumours are diagnosed in ~13000 people in Britain each year (of which 60 % are metastatic), 20 % of all cancer patients will develop secondary metastatic tumours in the brain and brain tumours are the most common solid tumour in children. Dr. Matt Baker and colleagues from the University of Central Lancaster, Lancashire Teaching Hospital and Dublin Institute of Technology have reported a study on the use of Raman spectroscopy to aid the diagnosis of brain cancer.

In this HOT new Analytical Methods paper, the team showed differences in spectra obtained by Raman scattering at the air-tissue interface and immersion Raman (where the sample is submerged in an appropriate medium, such as water) at the water-tissue interface. Immersion Raman was then used to identify differences between the tissue classes. Multivariate analysis was employed to differentiate between primary malignant tumours (glioblastoma multiforme), metastatic tumours and normal brain tissue with impressive sensitivity and specificity.  To read more about this study download the full article below, which is free to access until March 7th.

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Investigating the use of Raman and immersion Raman spectroscopy for spectral histopathology of metastatic brain cancer and primary sites of origin
Leanne M. Fullwood, Graeme Clemens, Dave Griffiths, Katherine Ashton, Timothy P. Dawson, Robert W. Lea, Charles Davis, Franck Bonnier, Hugh J. Byrne and Matthew J. Baker 
Journal Article
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C3AY42190B

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Upgraded Lab-on-a-Chip for Real-Time Detection of Food-borne Pathogens

Oliver Strohmeier and his colleagues from the University of Freiburg in Germany have developed a novel PCR-based platform to detect food-borne pathogens. Named “LabDisk”, the device implements centrifugal microfluidics for sample separation, and can be subsequently transferred to a commercially available thermocycler for real-time PCR amplification of pathogens including Listeria monocytogenes, Salmonella typhimurium, EHEC, Staphylococcus aureus, Citrobacter freundii, and Campylobacter jejuni. Importantly, LabDisk incorporates on-chip quality controls to help validate test results, and enables quantitative as well as qualitative testing. This new approach brings molecular detection one step closer to fully integrated sample-to-answer food testing.

Scheme of "LabDisk" for Detection of Foodborne Pathogens

"LabDisk" for Detection of Foodborne Pathogens

Download the full article, free until March 7th!

Real-time PCR based detection of a panel of food-borne pathogens on a centrifugal microfluidic “LabDisk” with on-disk quality controls and standards for quantification

Oliver Strohmeier, Nico Marquart, Daniel Mark, Günter Roth, Roland Zengerle and Felix von Stetten

Anal. Methods, 2014, Advance Article

DOI: 10.1039/C3AY41822G, Paper

Let us know what your thoughts are by leaving a comment!

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Keeping food safe: A novel immunoassay for milk analysis

Hybrid chemiluminescence immunoassays

The transfer of veterinary drugs into food products is of major concern to a world already struggling to combat antibiotic resistance. Antibiotics such as chloramphenicol also have serious side effects in humans, including bone marrow depression and acute leukemia. Despite government bans on the use of such drugs in food-producing animals in a number of countries, cases of food poisoning caused by contaminated meat continue to occur.

Researchers led by Hiayang Jiang at the China Agricultural University in Beijing have developed a novel method for the analysis of two key drugs, chloramphenicol (CAP) and clenbuterol (CLE), which can simultaneously detect trace amounts of each compound in milk samples.

Traditional detection methods have relied on gas and liquid chromatography, and mass spectrometry, which require expensive instrumentation and highly trained technicians. Jiang and coworkers have designed a hybrid chemiluminescence immunoassay to detect trace amounts of CAP and CLE in a single analysis, with minimal cost and time requirements.

This paper will be free to read until the 27th of February 2014.

Simultaneous determination of chloramphenicol and clenbuterol in milk with hybrid chemiluminescence immunoassays
Xiaoqi Tao, Jianzhong Shen, Xingyuan Cao, Zhanhui Wang, Xiaoping Wu and Haiyang Jiang
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C3AY41744A

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HOT articles in Analytical Methods

Take a look at our new hot articles just published in Analytical Methods. These papers are all free to read until February 28th 2014. Enjoy the reading!

Using spectral analysis and fluorescence lifetimes to discriminate between grass and tree pollen for aerobiological applications
David J. O’Connor, Pierre Lovera, Daniela Iacopino, Alan O’Riordan, David A. Healy and John R. Sodeau
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C3AY41093E, Paper

A green HPLC method for the analysis and stability study of flavoxate HCl using micellar eluent
Rania Nabih El-Shaheny, Nahed Mahmoud El-Enany and Fathalla Fathalla Belal
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C3AY41318G, Paper

Trap-and-release membrane inlet ion mobility spectrometry for on-line measurement of trace propofol in exhaled air
Qinghua Zhou, Enyou Li, Xin Wang, Yulei Gong, Lei Hua, Weiguo Wang, Tuanshuai Qu, Jinghua Li, Yiping Liu, Changsong Wang and Haiyang Li
Anal. Methods, 2014,6, 698-703
DOI: 10.1039/C3AY41545G, Paper

Microwave-assisted synthesis of ionic liquid-modified silica as a sorbent for the solid-phase extraction of phenolic compounds from water
Ping Su, Ruoyu Wang, Yang Yu and Yi Yang
Anal. Methods, 2014,6, 704-709
DOI: 10.1039/C3AY41771A, Paper

Electrostatic fabrication of oleylamine capped nickel oxide nanoparticles anchored multiwall carbon nanotube nanocomposite: A robust electrochemical determination of riboflavin at nanomolar levels
Deivasigamani Ranjith Kumar, Devaraj Manoj and Jayadevan Santhanalakshmi
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C3AY41810C, Paper

OpenFluor– an online spectral library of auto-fluorescence by organic compounds in the environment
Kathleen R. Murphy, Colin A. Stedmon, Philip Wenig and Rasmus Bro
Anal. Methods, 2014,6, 658-661
DOI: 10.1039/C3AY41935E, Communication

Biases in ketone measurements using DNPH-coated solid sorbent cartridges
Steven Sai Hang Ho, Judith C. Chow, John G. Watson, Ho Sai Simon Ip, Kin Fai Ho, Wen Ting Dai and Junji Cao
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C3AY41636D, Communication

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HOT Articles in Analytical Methods

Take a look at our new hot articles just published in Analytical Methods. These papers are all free to read until January 6th 2014. Enjoy the reading!

Multianalytical approach to explain the darkening process of hematite pigment in paintings from ancient Pompeii after accelerated weathering experiments
Maite Maguregui, Kepa Castro, Héctor Morillas, Josu Trebolazabala, Ulla Knuutinen, Rita Wiesinger, Manfred Schreiner and Juan Manuel Madariaga
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C3AY41741G, Paper

A new method to determine the thickness of platinum nanofilm simply by measuring its electrical resistance
Yujing Sun, Zhiwei Wen, Fugang Xu, Yue Zhang, Yan Shi, Haichao Dai and Zhuang Li
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C3AY41488D, Communication

A real-time cell-electronic sensing method for comparative analysis of toxicity of water contaminants
Haiying Du, Jinhua Li, Birget Moe, Claire F. McGuigan and Xing-Fang Li
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C3AY41686K, Paper

Magnetic imprinted surface enhanced Raman scattering (MI-SERS) based ultrasensitive detection of ciprofloxacin from a mixed sample
Zhinan Guo, Lei Chen, Haiming Lv, Zhi Yu and Bing Zhao
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C3AY40866C, Paper

Synthesis, characterization and adsorption performance of molecularly imprinted nanoparticles for tripterine by precipitation polymerization
Yuan Liu, Guifeng Zhang, Lihong Deng, Jiandu Lei, Lianyan Wang and Jing He
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C3AY41772G, Paper

Selection, identification and application of a DNA aptamer against Staphylococcus aureus enterotoxin A
Yukun Huang, Xiujuan Chen, Yu Xia, Shijia Wu, Nuo Duan, Xiaoyuan Ma and Zhouping Wang
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C3AY41576G, Paper

Multianalytical approach to explain the darkening process of hematite pigment in paintings from ancient Pompeii after accelerated weathering experiments

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Dissecting the Big Topics of Very Small Fluidic Devices

From the development of macro-, then micro- and now nano-fluidic devices, the science of biomolecule and bioparticle separation continues to evolve to meet the requirements of growing analytical applications. As new discoveries unravel innovative technologies, different problems for investigation also begin to emerge. Jie Xuan and Milton L. Lee from Brigham Young University, Utah, USA evaluate the progress of fluidic devices, and discuss some of the possibilities for future development. Find out more by accessing the link below. This paper will be free to read until 6 January 2014.

Let us know what your thoughts are by leaving a comment!

Size separation of biomolecules and bioparticles using micro/nanofabricated structures
Jie Xuana and Milton L. Lee
Anal. Methods, 2014, 6, 27-37
DOI: 10.1039/C3AY41364K

Micro/Nanostructures for Molecular Separation

Micro/Nanostructures for Molecular Separation

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HOT Articles in Analytical Methods

Take a look at our new HOT articles just published in Analytical Methods! These papers are all free to read for the next three weeks. Enjoy!

Development of a rapid detection method for seven pesticides in cucumber using hollow fibre liquid phase microextraction and ion mobility spectrometry
Jianfeng Wang, Zhongxia Zhang, Zhenxia Du and Wenjun Sun
Anal. Methods, 2013, 5, 6592-6597
DOI: 10.1039/C3AY40667A, Paper

Molecularly imprinted polymer-liquid chromatography/fluorescence for the selective clean-up of hydroxylated polycyclic aromatic hydrocarbons in soils
Oriol Baltrons, Montserrat López-Mesas, Cristina Palet, Franck Le Derf and Florence Portet-Koltalo
Anal. Methods, 2013, 5, 6297-6305
DOI: 10.1039/C3AY41227J, Paper

Analysis of cadmium-based pigments with time-resolved photoluminescence
Anna Cesaratto, Cosimo D’Andrea, Austin Nevin, Gianluca Valentini, Francesco Tassone, Roberto Alberti, Tommaso Frizzi and Daniela Comelli
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C3AY41585F, Paper

Facile detection of latent fingerprints on various substrates based on perylene probe excimer emission
Fangyuan Wang, Jian Chen, Huipeng Zhou, Wenying Li, Qingfeng Zhang and Cong Yu
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C3AY41802B, Communication

Investigation into dissolved neutral sugars and their microbial conversion in natural and artificially produced dissolved organic matter using ion chromatography with pulsed amperometric detection and reversed-phase liquid chromatography-high resolution mass spectrometry
Sara Sandron, Richard Wilson, Ruth Larragy, Margaret V. McCaul, Pavel N. Nesterenko, Brian Kelleher and Brett Paull
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C3AY41549J, Paper

Simple density-based particle separation in a microfluidic chip
Daisuke Sugiyama, Yuki Teshima, Kenichi Yamanaka, Maria Portia Briones-Nagata, Masatoshi Maeki, Kenichi Yamashita, Masashi Takahashi and Masaya Miyazaki
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C3AY40971F, Technical Note

Hydrophilic interaction/cation-exchange chromatography for glycopeptide enrichment by using a modified strong-cation exchange material
Linlin Chen, Xuefang Dong, Liwei Cao, Zhimou Guo, Long Yu, Lijuan Zou and Xinmiao Liang
Anal. Methods, 2013, 5, 6919-6924
DOI: 10.1039/C3AY41590B, Paper

A luminescence-based assay of UDP-sugar producing pyrophosphorylases
Daniel Decker, Stina Lindberg, Jonas Eriksson and Leszek A. Kleczkowski
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C3AY41811A, Communication

A nuclear forensic method for determining the age of radioactive cobalt sources
Luc Charbonneau, Jean-Michel Benoit, Slobodan Jovanovic, Nadereh St-Amant, Stephen Kiser, Michael W. Cooke, Jean-François Mercier, Kathy Nielsen, David Kelly, Pavel Samuleev, Raphael Galea, Kimberly Moore, Patrick R. B. Saull, David B. Chamberlain, Jennifer L. Steeb, Donald G. Graczyk, Yifen Tsai, Vivian S. Sullivan, Ike C. Dimayuga, Youqing Shi, Raghu Rao and Dominic Larivière
Anal. Methods, 2014, Advance Article
DOI: 10.1039/C3AY41443D, Paper

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Answers to Endangered Animals Lies in their Scat

LC-MS for Animal Identification

LC-MS for Animal Identification

Studying rare or endangered species of wild animals is no easy task. Analysis of animal tracks and fecal matter left behind can provide some clues for species identification, as well as insight into animal behavior and habitation. However, these identification signs are elusive, and often confounded by variations in environmental conditions, as well as animal health and diet. While methods of molecular analysis such as DNA sequence analysis of animal scat samples can provide more informative answers, DNA contamination from other mammals can make accurate identification difficult. To circumvent some of these limitations, Udaya Nasini, Ali Shaikh and colleagues from the University of Arkansas in Little Rock, USA, have demonstrated the use of liquid chromatography-mass spectrometry (LC-MS) to determine the composition of bile acids in scat samples. Analysis using LC-MS provides a metabolic pattern that is characteristic of a distinct species, and in turn enables effective identification.

Read more about this work by accessing the link below. This paper will be free to read for the next three weeks.

Let us know what your thoughts are by leaving a comment below!

Determination of bile acid profiles in scat samples of wild animals by liquid chromatography-electrospray mass spectrometry
Udaya B. Nasini, Nandan Peddi, Punnamchandar Ramidi, Yashraj Gartia, Anindya Ghosh and Ali U. Shaikh
Anal. Methods, 2013,5, 6319-6324
DOI: 10.1039/C3AY41048J

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