Archive for the ‘Uncategorized’ Category

HOT articles in Analyst

Take a look at our most recent HOT Analyst articles, these are now free to access for the next few weeks!

Graphical Abstract

Rapid biodiagnostic ex vivo imaging at 1 μm pixel resolution with thermal source FTIR FPA
C. R. Findlay, R. Wiens, M. Rak, J. Sedlmair, C. J. Hirschmugl, Jason Morrison, C. J. Mundy, M. Kansiz and K. M. Gough
Analyst, 2015, 140, 2493-2503
DOI: 10.1039/C4AN01982B

Controlled growth of immunogold for amplified optical detection of aflatoxin B1
Xu Wang, Reinhard Niessner and Dietmar Knopp
Analyst, 2015, 140, 1453-1458
DOI: 10.1039/C4AN02281E

A Comparative Study of Graphene-Hydrogel Hybrid Bionanocomposites for Biosensing

S. L. Burrs, D. C. Vanegas, M. Bhargava, N. Mechulan, P. Hendershot, H. Yamaguchi, C. Gomes and E. S. McLamore
Analyst, 2015, 140, 1466-1476
DOI: 10.1039/C4AN01788A

Pre-Equlibration Kinetic Size-Exclusion Chromatography with Mass Spectrometry Detection (peKSEC-MS) for Label-Free Solution-Based
Jiayin Bao, Svetlana M. Krylova, Leonid T. Cherney, J. C. Yves Le Blanc, Patrick Pribil, Philip E. Johnson, Derek J. Wilson and Sergey N. Krylov
Analyst, 2015, 140, 990-994
DOI: 10.1039/C4AN02232G

Forensic determination of blood sample age using a bioaffinity-based assay
Juliana Agudelo, Crystal Huynh and Jan Halámek
Analyst, 2015, 140, 1411-1415
DOI: 10.1039/C4AN02269F
Graphical Abstract
Oxidative damage in DNA bases revealed by UV Resonant Raman spectroscopy

Francesco D’Amico, Francesca Cammisuli, Riccardo Addobbati, Clara Rizzardi, Alessandro Gessini, Claudio Masciovecchio, Barbara Rossi and Lorella Pascolo
Analyst, 2015, 140, 1477-1485
DOI: 10.1039/C4AN02364A

The lipid-reactive oxygen species phenotype of breast cancer. Raman spectroscopy and mapping, PCA and PLSDA for invasive ductal carcinoma and invasive lobular carcinoma. Molecular tumorigenic mechanis
Jakub Surmacki, Beata Brozek-Pluska, Radzislaw Kordek and Halina Abramczyk
Analyst, 2015, 140, 2121-2133
DOI: 10.1039/C4AN01876A

Self-cleaning properties in engineered sensors for dopamine electroanalytical detection

Guido Soliveri, Valentina Pifferi, Guido Panzarasa, Silvia Ardizzone, Giuseppe Cappelletti, Daniela Meroni, Katia Sparnacci and Luigi Falciola
Analyst, 2015, 140, 1486-1494
DOI: 10.1039/C4AN02219J

Near-infrared excited ultraviolet emitting upconverting phosphors as an internal light source in dry chemistry test strips for glucose sensing
T. Valta, V. Kale, T. Soukka and C. Horn
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN02028F

Micromotors to capture and destroy anthrax simulant spores
Jahir Orozco, Guoqing Pan, Sirilak Sattayasamitsathit, Michael Galarnyk and Joseph Wang
Analyst, 2015, 140, 1421-1427
DOI: 10.1039/C4AN02169J

Compact 3D-Printed Interface for Coupling Open Digital Microchips with Venturi Easy Ambient Sonic-Spray Ionization Mass Spectrometry
Jie-Bi Hu, Ting-Ru Chen, Chia-Hsien Chang, Ji-Yen Cheng, Yu-Chie Chen and Pawel L. Urban
Analyst, 2015, 140, 1495-1501
DOI: 10.1039/C4AN02220C

Rapid Microstructure Characterization of Polymer Thin Films with 2D-Array Multifocus Raman Microspectroscopy
Ashok Zachariah Samuel, Sohshi Yabumoto, Kenichi Kawamura and Koichi Iwata
Analyst, 2015, 140, 1847-1851
DOI: 10.1039/C4AN01983K
Graphical Abstract
Real-time detection of H5N1 influenza virus through hyperbranched rolling circle amplification

Seyed Vahid Hamidi, Hedayatollah Ghourchian and Gholamreza Tavoosidana
Analyst, 2015, 140, 1502-1509
DOI: 10.1039/C4AN01954G

Nitrogen-Doped Carbon Dots from Plant Cytoplasm as Selective and Sensitive Fluorescent Probes for Detecting P-Nitroaniline in Both Aqueous and Soil Systems
Haoran Yuan, Denian Li, Yan Liu, Xizhe Xu and Chuanxi Xiong
Analyst, 2015, 140, 1428-1431
DOI: 10.1039/C4AN01869A

Simultaneous strain and temperature sensing using slightly tapered optical fiber with inner air-cavity
H. F. Chen, D. N. Wang and Y. Wang
Analyst, 2015, 140, 1859-1862
DOI: 10.1039/C4AN02230K

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Phone camera checks water for arsenic

UK scientists have developed a mobile phone-based system to help people avoid drinking water contaminated with arsenic.1 The phone’s camera measures quantum dot fluorescence in response to arsenic, achieving a limit of detection as low as 5μM.

Approximately 57 million people worldwide encounter As(III) concentrations exceeding the World Health Organization (WHO) recommended maximum of 10μg/L on a regular basis. Chronic exposure to this well known carcinogen and poison, which binds to proteins and impairs cell function, is one of the largest environmental health disasters in the world. Finding a portable, easy-to-use method to measure levels of this most toxic form of arsenic in drinking water is therefore vital.

Read the full article in Chemistry World >>>


A step towards Mobile Arsenic measurement for surface waters
Camille Ann De Villiers, Marta C Lapsley and Elizabeth A H Hall
Analyst, 2015, Accepted Manuscript
DOI: 10.1039/C4AN02368D

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Self-cleaning sensors see the light

Graphical AbstractScientists in Italy have engineered a cheap and simple electrochemical sensor that cleans itself when exposed to ultraviolet light. Their system offers a route towards self-cleaning electrodes with myriad environmental and biomedical sensing applications – from detecting pollutants in water to monitoring medications in blood.

Open any book on chemical or biological sensors and you’ll find a lot of content on electrochemical devices. This prevalence is testament to the importance and advantages of electrode-based sensing; and electrodes containing nanomaterials are becoming increasingly popular, owing to their high surface-to-volume ratio, which can improve their sensitivity and lower costs.

Read the full article in Chemistry World >>


Self-cleaning properties in engineered sensors for dopamine electroanalytical detection
Guido Soliveri, Valentina Pifferi, Guido Panzarasa, Silvia Ardizzone, Giuseppe Cappelletti, Daniela Meroni, Katia Sparnacci and Luigi Falciola
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN02219J

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HOT articles in Analyst

Take a look at our most recent HOT Analyst articles, these are now free to access for the next few weeks!

Label-free phenotyping of peripheral blood lymphocytes by infrared imaging
M. Verdonck, S. Garaud, H. Duvillier, K. Willard-Gallo and E. Goormaghtigh
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01855A

Graphical Abstract

PNGase F-mediated incorporation of 18O into glycans for relative glycan quantitation
Wei Zhang, Weiqian Cao, Jiangming Huang, Hong Wang, Ji Wang, Chen Xie and Pengyuan Yang
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN02073A

A microelectrochemical biosensor for real-time in vivo monitoring of brain extracellular choline
Keeley L. Baker, Fiachra B. Bolger and John P. Lowry
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN02027H

Differentiation of Prostate Cancer from Normal Tissue in Radical Prostatectomy Specimens by Desorption Electrospray Ionization and Touch Spray Ionization Mass Spectrometry
K. S. Kerian, A. K. Jarmusch, V. Pirro, M. O. Koch, T. A. Masterson, L. Cheng and R. G. Cooks
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN02039A

Multi-enzyme microreactor-based online electrochemical system for selective and continuous monitoring of acetylcholine
Yuqing Lin, Ping Yu and Lanqun Mao
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN02089H

Fluorescence Chemosensors for Hydrogen Sulfide Detection in Biological Systems
Zhi Guo, Guiqiu Chen, Guangming Zeng, Zhongwu Li, Anwei Chen, Jiajia Wang and Longbo Jiang
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01909A

Marker-free automated histopathological annotation of lung tumour subtypes by FTIR-Imaging
Frederik Großerueschkamp, Angela Kallenbach-Thieltges, Thomas Behrens, Thomas Brüning, Matthias Altmayer, Georgios Stamatis, Dirk Theegarten and Klaus Gerwert
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01978D

Universal Electronics for Miniature and Automated Chemical Assays
Pawel L. Urban
Analyst, 2015, Advance Article
DOI:
10.1039/C4AN02013H

Graphical Abstract

Raman microimaging of murine lungs: insight into the vitamin A content
K. M. Marzec, K. Kochan, A. Fedorowicz, A. Jasztal, K. Chruszcz-Lipska, J. Cz. Dobrowolski, S. Chlopicki and M. Baranska
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01881H

Stereospecific recognition and quantitative structure-activity relationship between antibodies and enantiomers: ofloxacin as model hapten
Hongtao Mu, Baoling Wang, Zhenlin Xu, Yuanming Sun, Xinan Huang, Yudong Shen, Sergei A. Eremin, Anatoly V. Zherdev, Boris B. Dzantiev and Hongtao Lei
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN02155J

A colorimetric method of analysis for trace amounts of hydrogen peroxide with the use of the nano–properties of Molybdenum disulfide
Xinrong Guo, Yong Wang, Fangying Wu, Yongnian Ni and Serge Kokot
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01950D

Infrared spectral signature of human lymphocyte subpopulations from peripheral blood
N. Wald, A. Legat, C. Meyer, D. E. Speiser and E. Goormaghtigh
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN02247E

Screening and mapping pigments in paintings using scanning electrochemical microscopy (SECM)
Antonio Doménech-Carbó, María Teresa Doménech-Carbó, Miguel Silva, Francisco Manuel Valle-Algarra, José Vicente Gimeno-Adelantado, Francisco Bosch-Reig and Rufino Mateo-Castro
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01911C

Transmission versus transflection mode in FTIR analysis of blood plasma: is the EFSW effect the only reason of the observed spectral distortions?
Emilia Staniszewska-Slezak, Anna Rygula, Kamilla Malek and Malgorzata Baranska
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01842G

Multivariate statistical methodologies applied in biomedical Raman spectroscopy: Assessing the validity of partial least squares regression using simulated model datasets.
Mark E. Keating, Haq Nawaz, Franck Bonnier and Hugh J. Byrne
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN02167C

A colorimetric nitrite detection system based on Ag@Au nanoparticles with excellent selectivity and high sensitivity
Tianhua Li, Yonglong Li, Yujie Zhang, Chen Dong, Zheyu Shen and Aiguo Wu
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01583E

Flow-through polymerase chain reaction inside a seamless 3D helical microreactor fabricated utilizing a silicone tube and a paraffin mold
Wenming Wu, Kieu The Loan Trinh and Nae Yoon Lee
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01675K

Graphical Abstract

ß-Cyclodextrin functionalised gold nanoclusters as a luminescent probe for the ultrasensitive detection of dopamine
Rui Ban, E. S. Abdel-Halim, Jianrong Zhang and Jun-Jie Zhu
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN02161D

In-vivo and continuous measurement of bisulfide in the hippocampus of rat’s brain by on-line integrated microdialysis/droplet-based microfluidic system
Feidan Gu, Xiaoyu Zhou, Xiaocui Zhu, Meiping Zhao, Jie Hao, Ping Yu and Lanqun Mao
Analyst
, 2015, Advance Article
DOI: 10.1039/C4AN01974A, Paper

Infrared imaging of MDA-MB-231 breast cancer cell line phenotypes in 2D and 3D cultures
Margarita Smolina and Erik Goormaghtigh
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01833H

High throughput absorbance spectra of cancerous cells: a microscopic investigation of spectral artifacts
A. Mignolet and E. Goormaghtigh
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01834F

Label-free imaging and identification of typical cells of acute myeloid leukaemia and myelodysplastic syndrome by Raman microspectroscopy
R. Vanna, P. Ronchi, A. T. M. Lenferink, C. Tresoldi, C. Morasso, D. Mehn, M. Bedoni, S. Picciolini, L. W. M. M. Terstappen, F. Ciceri, C. Otto and F. Gramatica
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN02127D

Infrared imaging of primary melanoma reveals hints of regional and distant metastases
N. Wald and E. Goormaghtigh
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01831A

Pituitary gland under infrared light – in search of a representative spectrum for homogenous regions
A. Banas, K. Banas, A. Furgal-Borzych, W. M. Kwiatek, B. Pawlicki and M. B. H. Breese
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01985G

Design of molecularly imprinted conducting polymer protein-sensing films via substrate-dopant binding
Elena Komarova, Matt Aldissi and Anastasia Bogomolova
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01965B

Vibrational signatures to discriminate liver steatosis grades
Chengyuan Peng, Franck Chiappini, Slávka Kaščáková, Mélanie Danulot, Christophe Sandt, Didier Samuel, Paul Dumas, Catherine Guettier and François Le Naour
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01679C

Graphical AbstractCompetitive evaluation of data mining algorithms for use in classification of leukocyte subtypes with Raman microspectroscopy
A. Maguire, I. Vega-Carrascal, J. Bryant, L. White, O. Howe, F. M. Lyng and A. D. Meade
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01887G

Loss of the preferential control over the striato-nigral direct pathway by striatal NMDA receptors in a rat model of Parkinson’s disease
Michele Morari and Martina Fantin
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01918K

Infrared Micro-spectroscopy for Cyto-pathological Classification of Esophageal Cells
Douglas Townsend, Miloš Miljković, Benjamin Bird, Kathleen Lenau, Oliver Old, Max Almond, Catherine Kendall, Gavin Lloyd, Neil Shepherd, Hugh Barr, Nick Stone and Max Diem
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01884B

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Infrared offers odds on skin cancer spreading

Scientists in Belgium have shown that infrared spectrometry can help predict how likely it is that a melanoma tumour, the deadliest and most common form of skin cancer, has spread to other organs.

Tumour spread, or metastasis, is the main threat to survival in melanoma patients. However, no biomarkers have been identified to indicate a high risk of metastasis and visual assessment of primary tumours by a trained pathologist is unlikely to reveal if cancerous cells have escaped to other parts of the body.

Graphical Abstract

Read the full article in Chemistry World



Infrared imaging of primary melanoma reveals hints of regional and distant metastases

N. Wald and E. Goormaghtigh
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01831A

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Seeing glucose through the skin

Graphical AbstractScientists in Germany have developed a spectroscopy method to measure diabetics’ glucose levels through their skin.

When a sample is irradiated with IR light, it produces a temperature increase and when this heat diffuses to a material in contact with the sample, a temperature gradient is created, causing a thermal lens – just like the mirage effect you see in the air on the surface of a hot road. By examining the deflection of a probe beam across this lens, you can study the thermal and optical properties of the sample.

Read the full article in Chemistry World


Photothermal deflectometry enhanced by total internal reflection enables non-invasive glucose monitoring in human epidermis
M.A.Pleitez, O.Hertzberg, A.Bauer, M.Seeger, T.Lieblein, H.v.Lilienfeld-Toalb and W.Mäntelea
Analyst, 2015,  Advance Article
DOI: 10.1039/C4AN01185F

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Ultrasensitive peanut allergy test

Graphical Abstract

Scientists in the US have developed an ultrasensitive procedure for spotting anti-peanut antibodies in blood.

Peanut allergies are recognised as one of the most serious food allergies, sometimes being fatal, and the severity of one’s allergy can change or develop over time. Diagnosis tends to combine medical history with clinical assays but often fails to indicate how severe an allergy is.

James Rusling, from the University of Connecticut, and colleagues, hope to develop their immunoarray into a system that diagnoses the severity of a patient’s peanut allergy. Their surface plasmon resonance (SPR) array is the first of its kind to record measurements using both carbohydrate and peptide epitopes from glycoprotein Arachis hypogaes h2 (Ara-h2). Ara-h2 is the most potent allergen from the Arachis hypogaes family, the major peanut allergens for sufferers. UUUTEHRTH

Read the full article in Chemistry world


Ultrasensitive carbohydrate-peptide SPR imaging microarray for diagnosing IgE mediated peanut allergy
Amit A. Joshi, Mark W. Peczuh, Challa V. Kumar and James F. Rusling
Analyst
, 2014,139, 5728-5733
DOI: 10.1039/C4AN01544D

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HOT articles in Analyst

Take a look at our recent HOT Analyst articles, these are now free to access for the next few weeks!

A Smart Ink for the Assessment of Low Activity Photocatalytic Surfaces
Andrew Mills, Christopher O’Rourke and Nathan Wells
Analyst, 2014, 139, 5409-5414
DOI: 10.1039/C4AN01375A

Graphical Abstract

Screen-Printed Back-to-Back Electroanalytical Sensors
Jonathan P. Metters, Edward P. Randviir and Craig E. Banks
Analyst, 2014, 139, 5339-5349
DOI: 10.1039/C4AN01501K

Fabrication and laser patterning of polystyrene optical oxygen sensor films for lab-on-a-chip applications
S. M. Grist, N. Oyunerdene, J. Flueckiger, J. Kim, P. C. Wong, L. Chrostowski and K. C. Cheung
Analyst, 2014, 139, 5718-5727
DOI: 10.1039/C4AN00765D

Reactive intermediate detection in real time via paper assisted thermal ionization mass spectrometry
Jiying Pei, Yanbiao Kang and Guangming Huang
Analyst, 2014, 139, 5354-5357
DOI: 10.1039/C4AN01343C

DNA Bioassay-on-Chip using SERS Detection for Dengue Diagnosis
Hoan T. Ngo, Hsin-Neng Wang, Andrew M. Fales, Bradly P. Nicholson, Christopher W. Woods and Tuan Vo-Dinh
Analyst, 2014, 139, 5655-5659
DOI: 10.1039/C4AN01077A

Aptasensor for potassium based on RecJf exonuclease mediated signal amplification
Peng Miao, Yuguo Tang, Bidou Wang, Kun Han, Xifeng Chen and Haixuan Sun
Analyst, 2014, 139, 5695-5699
DOI: 10.1039/C4AN01350F

Rapid, Highly Sensitive Detection of Herpes Simplex Virus-1 using Multiple Antigenic Peptide-Coated Superparamagnetic Beads
Ying-Fen Ran, Conor Fields, Julien Muzard, Viktoryia Liauchuk, Michael Carr, William Hall and Gil U. Lee
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN00774C


New algorithm for identification of components in a mixture: application to Raman spectra of solid amino acids

Sylwester Gawinkowski, Agnieszka Kaminska, Tomasz Rolinski and Jacek Waluk
Analyst, 2014, 139, 5755-5764
DOI: 10.1039/C4AN01159G

Cold neutron diffraction contrast tomography of polycrystalline material
S. Peetermans, A. King, W. Ludwig, P. Reischig and E. H. Lehmann
Analyst, 2014, 139, 5765-5771
DOI: 10.1039/C4AN01490A

Tailoring recognition clefts from non-specific recognition matrices in mixed molecular arrays
Nivarthi Ramesh and Archita Patnaik
Analyst, 2014, 139, 5772-5780
DOI: 10.1039/C4AN01120A

Graphical Abstract

Glyconanoparticles for colorimetric bioassays
María J. Marín, Claire L. Schofield, Robert A. Field and David A. Russell
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01466A

Nanocoax for Optical and Electronic Devices
Binod Rizal, Juan M. Merlo, Michael J. Burns, Thomas C. Chiles and Michael J. Naughton
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN01447B

3D printed metal columns for capillary liquid chromatography
S. Sandron, B. Heery, V. Gupta, D. A. Collins, E. P. Nesterenko, P. N. Nesterenko, M. Talebi, S. Beirne, F. Thompson, G. G. Wallace, D. Brabazon, F. Regan and B. Paull
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN01476F

Droplet microfluidics in (bio) chemical analysis
Evgenia Yu Basova and Frantisek Foret
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN01209G

A TEM protocol for quality assurance of in vitro cellular barrier models and its application to the assessment of nanoparticle transport mechanisms across barriers
Dong Ye, Kenneth A. Dawson and Iseult Lynch
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN01276C

A novel molecularly imprinted chitosan-acrylamide, graphene, ferrocene composite cryogel biosensor used to detect microalbumin
Amin Fatoni, Apon Numnuam, Proespichaya Kanatharana, Warakorn Limbut and Panote Thavarungkul
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN01000K

Rapid identification of synthetic colorants in food samples by using indium oxide nanoparticle-functionalized porous polymer monolith coupled with HPLC-MS/MS
Ruifang Qi, Xiao Zhou, Xiqian Li, Jiutong Ma, Chunmei Lu, Jun Mu, Xuguang Zhang and Qiong Jia
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN01392A

Graphical Abstract

HPLC-MRM Relative Quantification Analysis of Fatty Acids Based on a Novel Derivatization Strategy
Tie Cai,Hu Ting, Zhang Xin-Xiang, Zhou Jiangb and Zhang Jin-Lan
Analyst, 2014, 139, 6154-6159
DOI: 10.1039/C4AN01314J


Multimodal Optical Characterisation of Collagen Photodegradation by Femtosecond Infrared Laser Ablation

A. Manickavasagam, L. M. Hirvonen, L. N. Melita, E. Z. Chong, R. J. Cook, L. Bozecc and F. Festy
Analyst, 2014, 139, 6135-6143
DOI
: 10.1039/C4AN01523A

Ion Collision Cross Section Measurements in Quadrupole Ion Traps Using a Time-frequency Analysis Method
Muyi He, Dan Guo, Yu Chen, Xingchuang Xiong, Xiang Fangc and Wei Xu
Analyst, 2014, 139, 6144-6153
DOI: 10.1039/C4AN01216J

Label-Free Detection of DNA by Combining Gated Mesoporous Silica and Catalytic Signal Amplification of Platinum Nanoparticle
Zhifei Wang, Xia Yang, Jie Feng, Yongjun Tang, Yanyun Jianga and Nongyue He
Analyst, 2014, 139, 6088-6091
DOI: 10.1039/C4AN01539H

Molecular phenotypic profiling of a Saccharomyces cerevisiae strain at the single-cell level
A. Mareike Schmidt, Stephan R. Fagerer, Konstantins Jefimovs, Florian Buettner, Christian Marro,   Erdem C. Siringil, Karl L. Boehlen, Martin Pabstb and Alfredo J. Ibáñez
Analyst, 2014, 139, 5709-5717
DOI: 10.1039/C4AN01119H

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New test accelerates herpes detection

A new assay for spotting the virus responsible for cold sores has been developed by scientists in Ireland.

Graphical Abstract

It is estimated that between 60–95% of adults worldwide are infected with the herpes simplex virus-1 (HSV-1) and although the symptoms are usually limited to sores or blisters, in rare cases it can infect the central nervous system, which is fatal in 70% of untreated cases. If diagnosed early, antiviral therapy can lead to a positive outcome, thus emphasising the need for rapid diagnostic methods.

Interested to know more? Read the full article in Chemistry World here…

Rapid, highly sensitive detection of herpes simplex virus-1 using multiple antigenic peptide-coated superparamagnetic beads
Ying-Fen Ran, Conor Fields, Julien Muzard, Viktoryia Liauchuk, Michael Carr, William Hall and Gil U. Lee
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN00774C, Paper

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SPEC 2014

The International conference, SPEC 2014: Shedding New Light on Disease, was held on the 17th – 22nd August in Krakow, Poland. The conference was Co-chaired by Prof. Malgorzata Baranska, Jagellonian University, Krakow, Poland, Prof. Hugh J. Byrne, Dublin Institute of Technology, Ireland, and Prof. Anna Sulkowska, Medical University of Silesia, Katowice, Poland.

The event was the 8th in the series of biennial conferences, the aim of which is to bring together clinicians and scientists who have joined forces in the quest for novel biomedical applications of Infrared and Raman spectroscopy to improve patient care. Recent advances in the biological sciences and medicine have led to an increasing demand for real time and minimally invasive chemical and structural informa¬tion on biological materials. Due to its unique fingerprinting capability, vibrational spectroscopy plays a significant role in histopathology, cytology, biopsy targeting, surgical targets, treatment monitoring and drug studies.

The conference aimed to highlight further advances in state of the art and emerging biomedical applications of Vibrational Spectroscopy framed under the themes of:

Translational research into in vivo clinical applications

Ex vivo tissue biopsies, body fluids and cytological samples for diagnostics and disease studies

In vitro cell culture and 3D models for Research and Medical applications

while reviewing the challenges in the context of other emerging technologies. The programme was constructed in an attempt to prioritise real world applications from the outset, systematically progressing from research towards in vivo, ex vivo and in vitro applications, as well as emerging technologies and data processing, and featured Plenary, Invited and Contributed presentations in each session. The Flash Presentation session provided an opportunity for Early Stage Researchers to orally summarise their poster presentations to the audience in a one minute pitch on the Monday evening (18th), in advance of the formal poster session, on the Tuesday (19th). The Renishaw prize for Best Flash presentation was awarded to Helena Ukkonen, for her presentation entitled “FTIR Imaging Identifies the Changes in the Tumor Microenvironment Caused by Different Cancer Cells”.

Prof. Hugh J. Byrne presents the Analyst prize for best poster presentation to Niels Kröger, Heidelberg University, Germany

Niels Kröger, Heidelberg University, Germany, was awarded the Analyst Poster Prize for his presentation on “Rapid Hyperspectral Imaging of Biological Tissue Using Quantum Cascade Lasers”, while best poster prizes were also awarded to Elisa Barroso and Roeland Smits, Erasmus University Medical Center Rotterdam, for the presentation “High-Wavenumber Raman Spectroscopy to Discriminate Squamous Cell Carcinoma From Healthy Tissue Based on Water Content” sponsored by WITec, and Mohamed Abu Ayoobul Ansary, Jagiellonian University, Poland, for the presentation “Optimization of conjugation of Au/Ag-core/shell nanoparticles with antibodies for SERS studies on endothelial cells” sponsored by Bruker.

A feature of the conference was the daily discussion sessions which were aimed at a critical assessment of the routes towards the further development of clinical applications, under the heading “Quo Vadis? Spectropathology for the next generation” and were moderated by members of the SPEC International Advisory Board. The discussions, based around the three themes above, were loosely based on the agreed framework of:

(i)       What are the most achievable, strategic target applications
(ii)      What are the technical challenges, and how can they be addressed
(iii)     What are the challenges to implementation (legislative, clinical trials etc.), and how can they be addressed

The deliberations of the discussion groups will contribute to a “Roadmap” paper in the special edition of international peer reviewed journal, Analyst, co-authored by the IAB moderators. The discussion sessions also enabled outline presentations of the UK EPSRC CLIRSPEC (Clinical Infrared and Raman Spectroscopy for Medical Diagnosis) and the EU COST network Raman4clinics (European Network on Raman-based applications for clinical diagnostics) and their respective workprogrammes to promote and progress the translation of vibrational spectroscopic technologies into the clinical environment.

Prof. Peter Gardner (Uni. Of Manchester), addresses the Gala Dinner on behalf of the SPEC International Advisory Board, outlining proposals for the establishment of the International Clinical Spectroscopy Society.

The programme and discussions clearly demonstrated that there has been much progress in the understanding of the complexity of spectroscopic characterisation of biological materials, and data preprocessing and postprocessing methods can be applied with confidence to give true biochemical representations of tissue, cells and bodily fluids. Spectroscopic techniques remain a powerful tool for basic research and may find applications in vitro for toxicology and drug screening. Emerging technologies continue to push the performances in terms of acquisition speed, spatial resolution and multimodality. In terms of translation to a clinical environment, there remains a lack of standardisation of measurement and data analysis protocols ex vivo, while cost implications need also to be considered. The increased development of fibre probes shows great promise for in vivo intra-operative applications. However, the need to engage the medical community remains an imperative.

A significant outcome of the satellite meeting of the SPEC IAB was the agreement in principle to the establishment of an International Clinical Spectroscopy Society, as a not-for profit Private Company Limited by Guarantee with charitable status. The Society will primarily promote the translational of spectroscopy into the clinical environment to improve patient diagnosis and prognosis. The SPEC Conference Series will be the primary vehicle of the Society towards this goal. The IAB also accepted the proposal that the next in the series, SPEC 2016, will be held in Montreal, Canada.

The conference attracted 282 participants from 32 countries around the globe. The programme included 62 oral and 191 poster contributions. It was sponsored by a number of commercial enterprises and other organisations, including: Witec, Renishaw, Agilent Technologies, Bruker, NT-MDT, Art Photonics, Thermo-Scientific, Comef, Horiba Scientific, Bio-Tools, Photon Etc., London Spectroscopy, Analyst, CLIRSPEC, PAN, PAU, ABE, KNOW im. Smoluchowskiego, LOT Quantum Design.

The conference was held against the backdrop of the 650th anniversary celebrations of the Jagiellonian University, and enjoyed honorary patronage of the Jagiellonian University, the Mayor of the City of Krakow, the Malopolska Voivodeship and the Marshal of the Małopolska Voivodeship.

And remember, attendees of the SPEC 2014 conference are all invited to submit to the upcoming themed issue in Analyst: deadline 17th October, 2014
Contact us here for more information

Take a look at our previous SPEC themed issue; Optical Diagnosis

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