Archive for the ‘Hot Article 2014’ Category

HOT articles in Analyst

Take a look at our new HOT articles just published in Analyst and free for you for the next couple of weeks:

reMelting curve analysis as a tool for enrichment monitoring in the SELEX process
Jeroen Vanbrabant, Karen Leirs, Katrijn Vanschoenbeek, Jeroen Lammertyn and Luc Michiels
Analyst, 2014,139, 589-595
DOI: 10.1039/C3AN01884A, Paper

Graphical abstract: reMelting curve analysis as a tool for enrichment monitoring in the SELEX process

Nanostructured silver–gold bimetallic SERS substrates for selective identification of bacteria in human blood
Arumugam Sivanesan, Evelin Witkowska, Witold Adamkiewicz, Łukasz Dziewit, Agnieszka Kamińska and Jacek Waluk
Analyst, 2014,139, 1037-1043
DOI: 10.1039/C3AN01924A, Paper

Graphical abstract: Nanostructured silver–gold bimetallic SERS substrates for selective identification of bacteria in human blood

Investigation of non-specific signals in nanoporous flow-through and flow-over based sensors
Neeraj Kumar, Elena Froner, Romain Guider, Marina Scarpa and Paolo Bettotti
Analyst, 2014, Advance Article
DOI: 10.1039/C3AN01996A, Paper

Graphical abstract: Investigation of non-specific signals in nanoporous flow-through and flow-over based sensors

Selective detection of complementarity-determining regions of monoclonal antibody by limiting protease access to the substrate: nano-surface and molecular-orientation limited proteolysis
Noriko Iwamoto, Takashi Shimada, Yukari Umino, Chikage Aoki, Yutaka Aoki, Taka-Aki Sato, Akinobu Hamada and Hitoshi Nakagama
Analyst, 2014,139, 576-580
DOI: 10.1039/C3AN02104A, Communication

Graphical abstract: Selective detection of complementarity-determining regions of monoclonal antibody by limiting protease access to the substrate: nano-surface and molecular-orientation limited proteolysis

A model system for targeted drug release triggered by biomolecular signals logically processed through enzyme logic networks
Shay Mailloux, Jan Halámek and Evgeny Katz
Analyst, 2014,139, 982-986
DOI: 10.1039/C3AN02162A, Communication

Graphical abstract: A model system for targeted drug release triggered by biomolecular signals logically processed through enzyme logic networks

Biocatalytic analysis of biomarkers for forensic identification of gender
Saira Bakshi, Lenka Halámková, Jan Halámek and Evgeny Katz
Analyst, 2014,139, 559-563
DOI: 10.1039/C3AN02055J, Communication

Graphical abstract: Biocatalytic analysis of biomarkers for forensic identification of gender

Real-time trace gas sensing of fluorocarbons using a swept-wavelength external cavity quantum cascade laser
Mark C. Phillips, Matthew S. Taubman, Bruce E. Bernacki, Bret D. Cannon, Robert D. Stahl, John T. Schiffern and Tanya L. Myers
Analyst, 2014, Advance Article
DOI: 10.1039/C3AN01642K, Paper

Graphical abstract: Real-time trace gas sensing of fluorocarbons using a swept-wavelength external cavity quantum cascade laser

Frequency-encoded laser-induced fluorescence for multiplexed detection in infrared-mediated quantitative PCR
Adrian M. Schrell and Michael G. Roper
Analyst, 2014, Advance Article
DOI: 10.1039/C3AN02334F, Paper

Graphical abstract: Frequency-encoded laser-induced fluorescence for multiplexed detection in infrared-mediated quantitative PCR

Rapid profiling of enteric coated drug delivery spheres via Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS)
D. Fitzpatrick, R. Evans-Hurson, Y. Fu, T. Burke, J. Krüse, B. Vos, S. G. McSweeney, P. Casaubieilh and J. J. Keating
Analyst, 2014,139, 1000-1006
DOI: 10.1039/C3AN01809A, Paper

Graphical abstract: Rapid profiling of enteric coated drug delivery spheres via Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS)

Highly enhanced electrochemiluminescence based on pseudo triple-enzyme cascade catalysis and in situ generation of co-reactant for thrombin detection
Lijuan Xiao, Yaqin Chai, Ruo Yuan, Haijun Wang and Lijuan Bai
Analyst, 2014,139, 1030-1036
DOI: 10.1039/C3AN02134C, Paper

Graphical abstract: Highly enhanced electrochemiluminescence based on pseudo triple-enzyme cascade catalysis and in situ generation of co-reactant for thrombin detection

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Label-free biosensing using photonic crystals and single nanoparticles

Photonic crystal enhanced microscopy (PCEM) is a relatively new technique that utilizes a grating like substrate composed of a high refractive index material coating a low refractive index one. When irradiated with light at a resonant wavelength, this photonic crystal reflects all of the light, and is very sensitive to any changes on the surface.

Photonic Crystal Enhanced Microscopy of a nanoparticle on a photonic crystal

Photonic Crystal Enhanced Microscopy of a nanoparticle on a photonic crystal

Researchers at the University of Illinois in the United States studied the effects of gold nanoparticles binding to  photonic crystals composed of a liquid epoxy polymer and TiO2.  Although PCEM has been used to detect biological analytes without labels, they observed how a nanoparticle tag can reduce  the signal of a photonic crystal. Furthermore, they determined the distance required between the nanoparticles for detection, and this could be used in future amplification schemes such as in single molecule sensing.

To read more about this topic, click the link below. It will be free to read until February 28.

Single nanoparticle detection using photonic crystal enhanced microscopy
Yue Zhuo,  Huan Hu, Weili Chen,  Meng Lu,  Limei Tian,  Hojeong Yu, Kenneth D. Long,  Edmond Chow,  William P.   King, Srikanth Singamaneni  and  Brian T. Cunningham
Analyst, 2014, Advance Article
DOI: 10.1039/C3AN02295A

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HOT Articles in Analyst

Take a look at our new HOT articles just published in Analyst and free for you for the next couple of weeks:

Chemometric determination of lipidic parameters in serum using ATR measurements of dry films of solvent extracts
David Perez-Guaita, Angel Sanchez-Illana, Josep Ventura-Gayete, Salvador Garrigues and Miguel de la Guardia
Analyst, 2014,139, 170-178
DOI: 10.1039/C3AN01057K, Paper

Infrared imaging in breast cancer: automated tissue component recognition and spectral characterization of breast cancer cells as well as the tumor microenvironment
Audrey Benard, Christine Desmedt, Margarita Smolina, Philippe Szternfeld, Magali Verdonck, Ghizlane Rouas, Naima Kheddoumi, Françoise Rothé, Denis Larsimont, Christos Sotiriou and Erik Goormaghtigh
Analyst, 2014, Advance Article
DOI: 10.1039/C3AN01454A, Paper

SEDFIT–MSTAR: molecular weight and molecular weight distribution analysis of polymers by sedimentation equilibrium in the ultracentrifuge
Peter Schuck, Richard B. Gillis, Tabot M. D. Besong, Fahad Almutairi, Gary G. Adams, Arthur J. Rowe and Stephen E. Harding
Analyst, 2014,139, 79-92
DOI: 10.1039/C3AN01507F, Paper

Structured illumination for tomographic X-ray diffraction imaging
Joel A. Greenberg, Mehadi Hassan, Kalyani Krishnamurthy and David Brady
Analyst, 2014,139, 709-713
DOI: 10.1039/C3AN01641B, Communication

Molecular interactions of nanomaterials and organisms: defining biomarkers for toxicity and high-throughput screening using traditional and next-generation sequencing approaches
Rebecca Klaper, Devrah Arndt, Jared Bozich and Gustavo Dominguez
Analyst, 2014, Advance Article
DOI: 10.1039/C3AN01644G, Critical Review

Conformational and mechanical changes of DNA upon transcription factor binding detected by a QCM and transmission line model
Jorge de-Carvalho, Rogério M. M. Rodrigues, Brigitte Tomé, Sílvia F. Henriques, Nuno P. Mira, Isabel Sá-Correia and Guilherme N. M. Ferreira
Analyst, 2014, Advance Article
DOI: 10.1039/C3AN01682J, Paper

Real-time evaluation of aggregation using confocal imaging and image analysis tools
Zahra Hamrang, Egor Zindy, David Clarke and Alain Pluen
Analyst, 2014,139, 564-568
DOI: 10.1039/C3AN01693E, Communication

Enhancing the sensitivity of potential step voltammetry using chemometric resolution
Jiarun Tu, Wensheng Cai and Xueguang Shao
Analyst, 2014, Advance Article
DOI: 10.1039/C3AN01719B, Paper

Amplified plasmonic detection of DNA hybridization using doxorubicin-capped gold particles
Jolanda Spadavecchia, Ramesh Perumal, Alexandre Barras, Joel Lyskawa, Patrice Woisel, William Laure, Claire-Marie Pradier, Rabah Boukherroub and Sabine Szunerits
Analyst, 2014,139, 157-164
DOI: 10.1039/C3AN01794J, Paper

Quantitative dielectrophoretic tracking for characterization and separation of persistent subpopulations of Cryptosporidium parvum
Yi-Hsuan Su, Mikiyas Tsegaye, Walter Varhue, Kuo-Tang Liao, Lydia S. Abebe, James A. Smith, Richard L. Guerrant and Nathan S. Swami
Analyst, 2014,139, 66-73
DOI: 10.1039/C3AN01810E, Paper

A dual-plate ITO–ITO generator–collector microtrench sensor: surface activation, spatial separation and suppression of irreversible oxygen and ascorbate interference
Mohammad A. Hasnat, Andrew J. Gross, Sara E. C. Dale, Edward O. Barnes, Richard G. Compton and Frank Marken
Analyst, 2014,139, 569-575
DOI: 10.1039/C3AN01826A, Communication

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Nanoparticles for platelet adhesion and aggregation

On-chip evaluation of platelet adhesion and aggregation

The use of nanoparticles in diagnostic and therapeutic roles requires that we understand their interactions and behaviour within complex biological systems. Where clinical applications would involve intravenous injection of nanoparticle-based therapeutics, it will be necessary to understand the interaction between nanoparticles and native blood components.

To address this issue, Christy Haynes and coworkers from the University of Minnesota, USA, have created a microfluidic device coated with endothelial cells to mimic the walls of the vascular system. This initial in vitro approach was carried out with both activated and unactivated platelets in the presence of various (therapeutically-relevant) concentrations of fluorescently-labelled, mesophorous silica nanoparticles. The impact of nanoparticles on the critical platelet functions of adhesion and aggregation was assessed.

Microfluidic platforms are readily customised and future work would be expected to expand upon these initial conditions to advance our understanding of nanotoxicology and interaction studies.

To read more about this study and the impact of nanoparticles on platelet interactions you can access this Analyst HOT Article free until 6 January 2014:

On-chip evaluation of platelet adhesion and aggregation upon exposure to mesoporous silica nanoparticles
Donghyuk Kim, Solaire Finkenstaedt-Quinn, Katie R. Hurley, Joseph T. Buchman and Christy L. Haynes 
Analyst, 2014, Advance Article
DOI: 10.1039/C3AN01679J

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