Bioanalytical tools for enabling precision medicine – Themed collection in Progress!

Analyst has launched a themed collection to highlight bioanalytical tools for enabling precision medicine

The emphasis of this themed issue is on bioanalytical tools for enabling precision medicine. The field of healthcare continues to move from the inefficient, one-size-fits-all-patients medicine of today, toward the data-driven and personalised medicine of tomorrow. According to the Precision Medicine Initiative led by the National Institutes of Health, precision medicine is “an emerging approach for disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle for each person”. In cancer, precision medicine uses specific information about the patient and their tumour to help diagnose, plan treatment, determine optimal drug levels, monitor response to therapy, and/or assess likely disease recurrence.

In this collection we aim to cover bioanalytical tools for enabling precision medicine, including imaging, spectroscopy, machine learning and miniaturised technologies on both solid tumours and liquid biopsy samples. The focus of this collection is not limited to cancer but is relevant to other diseases such as cystic fibrosis, diabetes and infectious diseases.

Guest Editors

This collection is co-guest edited by Analyst Associate Editor Professor Steven Soper (The University of Kansas, Lawrence, USA) and Professor Andrew Godwin (Director, Molecular Oncology, The University of Kansas Medical Center, USA).

Professor Steven Soper

Professor Andrew Godwin

 

Submission deadline

31st May 2019 

Contribute to this collection

We welcome submissions of original research and review articles. Articles will be added to the collection as they are accepted and the resulting issue will benefit from extensive promotion.

About Analyst

Guided by Editor-in-Chief Duncan Graham and an international team of associate editors and editorial board membersAnalyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

Interested in contributing?

Email analyst-rsc@rsc.org 

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Outstanding Reviewers for Analyst in 2018

We would like to highlight the Outstanding Reviewers for Analyst in 2018, as selected by the editorial team, for their significant contribution to the journal. The reviewers have been chosen based on the number, timeliness and quality of the reports completed over the last 12 months.

We would like to say a big thank you to those individuals listed here as well as to all of the reviewers that have supported the journal. Each Outstanding Reviewer will receive a certificate to give recognition for their significant contribution.

Dr Hugh Byrne, Focas Institute, Dublin Institute of Technology ORCiD: 0000-0002-1735-8610

Professor Lingxin Chen, Chinese Academy of Sciences, Yantai Institute of Coastal Zone Research ORCiD: 0000-0002-3764-3515

Professor Jeremy Driskell, Illinois State University ORCiD: 0000-0001-5082-898X

Professor Ning Gan, Ningbo University ORCiD: 0000-0001-9772-2437

Professor Hideaki Hisamoto, Osaka Prefecture University ORCiD: 0000-0003-1067-4116

Professor Young-Pil Kim, Hanyang University ORCiD: 0000-0001-7234-1320

Professor Feng Li, Qingdao Agricultural University ORCiD: 0000-0002-3894-6139

Professor Yi-Tao Long, East China University of Science and Technology ORCiD: 0000-0003-2571-7457

Professor Zachary Schultz, The Ohio State University ORCiD: 0000-0003-1741-8801

Dr Bhavya Sharma, University of Tennessee ORCiD: 0000-0003-4388-5702

Dr Muhammad Shiddiky, Griffith University ORCiD: 0000-0003-4526-4109

Dr James Wade, Dow Chemical ORCiD: 0000-0002-9740-1905

We would also like to thank the Analyst board and the analytical chemistry community for their continued support of the journal, as authors, reviewers and readers.

 

If you would like to become a reviewer for our journal, just email us with details of your research interests and an up-to-date CV or résumé.  You can find more details in our author and reviewer resource centre

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Versatile electrochemical approaches – Themed collection in Progress!

 

Analyst has launched a themed collection focusing on versatile electrochemical approaches for sensing, biology, and energy.

Solving pressing challenges in these fields requires the development of enabling tools and strategies that converge in fundamental concepts of analysis to address materials properties and charge transfer. In this collection, we aim to cover the broad range of cutting-edge electrochemical approaches being explored for the detection of analytes and the understanding of processes relevant to energy and biological systems. These approaches encompass nanoscale electrochemistry, rational electrode design, biomolecular analysis, and interface-sensitive methods. Accordingly, this collection will feature new electroanalytical strategies in characterising energy storage and energy harvesting systems, in biomedical diagnostics, and in measurement and imaging sciences.

 

 

Joaquin Rodriguez Lopez

Damien Arrigan

 

Guest Editors

This collection is co-guest edited by Analyst Associate Editor Professor Damien Arrigan  (Curtin University, Australia) and Associate Professor Joaquín Rodríguez López (University of Illinois at Urbana-Champaign, USA).

 

 

 

 

 

Submission deadline: 30th September 2019 

 

 

Contribute to this collection

We welcome submissions of original research and review articles. Articles will be added to the collection as they are accepted and the resulting issue will benefit from extensive promotion.

About Analyst

Guided by Editor-in-Chief Duncan Graham and an international team of Associate Editors and Editorial Board membersAnalyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.

Interested in contributing?

Email analyst-rsc@rsc.org

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21st Australia and New Zealand Electrochemistry Symposium

Queensland University of Technology, Brisbane, Australia

The organising committee is especially interested in featuring the work from PhD research students and other early-career researchers. A confirmed keynote speaker is Prof. Andrea Russell from the University of Southampton, UK and Prof. Huijun Zhao from Griffith University, Australia.

Organising Committee

  • Prof. Anthony O’Mullane (QUT)
  • Dr. Muhammad Shiddiky (Griffith)
  • Dr. Yang Liu (JCU)
  • Dr. Ruth Knibbe (UQ)
  • Dr. Debbie Silvester-Dean (Curtin)
  • Prof. Damien Arrigan (Curtin)
  • Prof. Chuan Zhao (UNSW)
  • Ummul Sultana (QUT)

Important dates:

  • 8 February 2019: Deadline for abstract submission
  • 15 April 2019: early-bird registration deadline
  • 29 April 2019: Symposium

 

When: 29 -30 April 2019

Where: QUT, Gardens Point, OJW Room

Contact:

Anthony O’Mullane

Registration Fees

Early-bird** Normal
Members* $300 $350
Non-members $350 $400
Student members* $150 $200
Student non-members $200 $250
*RACI or ISE Members
**Early-bird rates: Before 15 April 2019

Please Click Here to Register

Please Click Here for the Flyer

Please Click Here for the Abstract Template

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1st European Top-Down Proteomics Symposium

The 1st European Top-Down Proteomics Symposium is taking place from 12th – 14th Febraury, 2019, in Paris, France.

The symposium will focus on top-down proteomics, the analysis of intact proteins and protein complexes using high-resolution mass spectrometry.

In this symposium, world-leading experts in top-down proteomics will present the most advanced technologies and approaches. A wide range of topics will be covered including the latest developments in instrumentation, sample preparation both in denaturing and native conditions, intact protein fractionation/separation, data analysis as well as applications in life sciences and human health.

Additionally, attendees will be encourage to take part in discussions on the future directions, challenges, and opportunities for top-down proteomics. In addition to notable scientists, the meeting will also attract younger researchers who are building their careers and are looking to interact with leaders in the field.

CONFIRMED SPEAKERS

Dr Rodolphe Antoine, University of Lyon, France
Dr Alain Beck, Laboratoires Pierre Fabre, France
Pr Isabelle Fournier, University of Lille, France
Pr Albert Heck, Utrecht University, The Netherlands
Pr Amy Herr, University of California, Berkeley, USA
Pr Ole Jensen, University of Southern Denmark, Denmark
Pr Neil Kelleher, Northwestern University, USA
Pr Alexander Makarov, Thermo Fisher Scientific, Germany
Pr Dame Carol Robinson, University of Oxford, United Kingdom
Pr Michal Sharon, Weizmann Institute, Israel
Dr Yuri Van der Burgt, Leiden University Medical Center, The Netherlands
Pr Vicki Wysocki, Ohio State University, USA

ROUNDTABLES AND MODERATORS (CTDP)

Sample preparation, intact protein separation,instrumentation, data analysis
Dr Ljiljana Pasa-Tolic, Pacific Northwest, National Laboratory, USA
Dr Ying Ge, University of Wisconsin, USA
Industrial and regulatory applications (i.e. antibody and biologics analysis)
Dr Yury Tsybin, Spectroswiss, Switzerland
Dr Jeffrey Agar, Northeastern University, USA
Future directions of top-down proteomics
Pr Neil Kelleher, Northwestern University, USA
Pr Joseph Loo, University of California Los Angeles, USA
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Emerging Investigator Series – Ashley Ross

We are delighted to introduce our latest Analyst Emerging Investigator, Ashley Ross!

Ashley Ross is an Assistant Professor of Chemistry at the University of Cincinnati (UC) and a member of the Neuroscience Department and Center for Pediatric Neuroscience. She received her BS in Chemistry in 2009 at Christopher Newport University and was an undergraduate intern at NASA Langley Research Center for 3 years working with Drs. Margaret Pippin and Gao Chen. She received a PhD in Chemistry in Dr. Jill Venton’s lab at the University of Virginia in 2014. In 2014, she became a post-doc in Dr. Rebecca Pompano’s lab at the University of Virginia and was an American Association of Immunologists (AAI) Careers in Immunology Fellow. Since 2017, she has been at UC working on developing electrochemical and microfluidic tools to investigate neurochemical regulated immunity.

Read Ashley’s Emerging Investigator Series paper “Subsecond detection of guanosine using fast-scan cyclic voltammetry” and find out more about her in the interview below:

 

Your recent Emerging Investigator Series paper focuses on subsecond detection of guanosine using fast-scan cyclic voltammetry. How has your research evolved from your first article to this most recent article?
Over the last 10 years, I have focused on developing bioanalytical tools to study complex chemical signaling. My early work in graduate school focused on developing electrochemical tools to study the other important purine, adenosine. Specifically, I developed a new electrode modification procedure which combined carbon nanotubes and Nafion to enhance adenosine detection and I developed a new waveform for fast-scan cyclic voltammetry. My research soon evolved from developing novel tools to studying the release and function of rapid adenosine signaling in the brain. I switched gears quite a bit during my post-doc, where I focused on developing microfluidic tools to locally stimulate live lymph node slices to study the importance of the spatial complexity of the immune system and to quantitate cytokine diffusion within live tissue. My current research interests are focused on developing tools to study communication between the brain and the immune system. This particular paper went back to my roots a bit. We are really interested in guanosine signaling because of its rich involvement in neuroinflammatory processes; however, detecting millisecond changes in guanosine signaling in real-time is not possible with current technology. With FSCV, we are able to explore that rapid mode of signaling.

What aspect of your work are you most excited about at the moment?
I am very excited about the possibility of using FSCV to study brain-immune communication. How the brain and not only its immune system but the peripheral immune system communicates is not well understood, in part due to current technology. We are excited about all the new tools we are developing in the lab to help solve this technological barrier.

In your opinion, what is the biggest advantage of the fast-scan cyclic voltammetry method for guanosine detection?
Fast-scan cyclic voltammetry has excellent temporal and spatial resolution. With this technique, we can make measurements every 100 ms within discrete regions of the brain! Because we get a cyclic voltammogram, we are able to help distinguish what we are measuring. In the case of guanosine, a rapid extracellular signaling profile exists but the current techniques in the field to study guanosine signaling do not have the temporal resolution to capture it. With FSCV, we are hoping we can learn some interesting things about guanosine signaling in the brain!

What do you find most challenging about your research?
The biology! The brain and immune system are so complex! You can develop a technique on the bench but it can fail as soon as it is put into a complex matrix like tissue. Also, it is really difficult to predict what to expect when studying complex biological systems. We make hypotheses but I tell my students to not fall in love with those ideas! Everything can change when you start making actual measurements!

How do you spend your spare time?
I am a mother of two beautiful children, 6 year old Haylee and 3 year old Elijah. My husband Ronnie and I definitely spend most of our spare time with them. My daughter is in ballet, so chauffeuring her around to ballet practice and rehearsals is fun! I also enjoy singing in my spare time. I have been singing and performing since high school so it is definitely a nice “outlet” from work!

Which profession would you choose if you were not a scientist?
I have always loved to perform whether it be in singing groups or in musicals, so probably a performer! But more realistically, maybe a paediatrician!

Can you share one piece of career-related advice or wisdom with other early career scientists?
I was given this advice and I think it is so valuable: In the early years, be in the lab with your students! When you are starting out, you are the expert and can help not only set the example in the lab but it helps foster a productive environment early on.

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SciX 2018, Atlanta, USA

SciX 2018, a conference featuring cutting edge developments in analytical sciences, instrumentation and unique applications, was held in Altanta, GA from October 21-26, 2018.

 

Award-Winning Scientists

The Analyst Emerging Investigator Lectureship 2018 recognizes an early career analytical scientist to raise the profile of the analytical sciences to the wider scientific community and general public. This year’s winner was Dr Wei Min, Columbia University, USA. His current research interests focus on developing novel optical spectroscopy and microscopy technology to address biomedical problems. In particular, his group has made important contributions to the development of stimulated Raman scattering (SRS) microscopy and its broad application in biomedical imaging including bioorthogonal chemical imaging of small molecules and super-multiplex vibrational imaging.

Wei Min presents his Analyst Emerging Investigator Lecture

 

Analyst Chair Duncan Graham presents Wei Min with the Analyst Emerging Investigator Lectureship in Atlanta, USA

 

Wei gave a fascinating presentation during the Monday morning session, which was followed by a highly attended symposium of personally hand-picked speakers.

Symposium speakers: Juergen Popp, Duncan Graham, Richard Zare, Wei Min, Lingyan Shi, Katsumasa Fujita.

 

Congratulations Wei!

 

It also gives us great pleasure to announce that Analytical Methods Associate Editor Michael Roper and former Analytical Methods Editor-in-Chief Sue Lunte both received awards at SciX 2018.

Michael Roper was the recipient of the AES Mid-Career Award. After being presented with his award, Michael delivered a plenary lecture titled  “Electrophoretic Methods for Investigating Dynamic Behaviour of Pancreatic Cells”.

Analytical Methods Associate Editor Michael Roper (L) receives the AES Mid-Career Award.

 

The ANACHEM Award was awarded to Sue Lunte, who delivered her plenary lecture “Adventures in Electrically Driven Miniaturized Separations Systems for Bioanalysis” on Thursday 25th October.

Analytical Methods former Editor-in-Chief Sue Lunte (R) is presented with the ANACHEM Award by Professor Dana Spence.

 

We are extremely proud of Michael and Sue. Congratulations on well-deserved awards.

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Heinrich Emanuel Merck Award for Analytical Science 2019

In memory of the company’s founder Heinrich Emanuel Merck, the Merck Award has celebrated excellence in analytical chemistry for over two decades. It is open to researchers up to the age of 45 years who are developing solutions to analytical problems in the life, material and environmental sciences. This award honors scientists who are developing innovative analytical methods in chemistry with new applications that aim to improve human life.

The prize will be awarded for the 17th time at a special award ceremony at the EuroAnalysis2019 in Istanbul, Turkey from 1st – 5th September, 2019.

The judging panel will be chaired by Professor Renato Zenobi (ETH Zürich) and supported by 5 intentionally renowned analytical scientists.

Applications and nominations should be submitted before the deadline on 31st December 2018 to the following address:

Professor Renato Zenobi
ETH Zürich
Laboratory of Organic Chemistry
HCI E 329
CH-8093 Zürich, Switzerland
Email: zenobi@org.chem.ethz.ch

Further details 

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SCIX 2018

Are you going to be at SciX 2018?

Analyst is proud to announce that Dr Wei Min (Columbia University, USA) is the winner of the 2018 Analyst Emerging Investigator Lectureship. Dr Min will be giving an award plenary on the topic of Seeing molecular vibrations: chemical imaging for biomedicine at 8:30 am on Monday 22 October.

We are also sponsoring a symposium in honour of Dr Wei Min (18AWD11) at 9:15 am, Monday 22 October, with a wonderful lineup of speakers including:

Richard Zare, Stanford University, USA
Duncan Graham, University of Strathclyde, UK
Juergen Popp, Leibniz Institute of Photonic Technology, Germany
Katsumasa Fujita, Osaka University, Japan
Lingyan Shi, Columbia University, USA

Two Board members of our sister journal Analytical Methods will be receiving prestigious awards at SciX 2018 and if you will be around, I encourage you to please do attend their plenary lectures and their award sessions.

• Michael Roper, Analytical Methods Associate Editor will be receiving the 2018 AES Electrophoresis Mid Career Award and will be giving a plenary lecture at 8.30am on Wednesday 24 October.

• Sue Lunte, former Editor-in-Chief of Analytical Methods and current Advisory Board member, will be receiving the 2018 Anachem Award and will be giving a plenary lecture at 8:00am on Thursday 25 October.

Look out for our Royal Society of Chemistry booth, number 904, during the conference. Executive Editor Jeanne Andres (Analyst, Analytical Methods, JAAS) and Deputy Editor Rebecca Brodie (JAAS) will be attending the conference and look forward to meeting you at SciX 2018.

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Emerging Investigator Series – Peng Miao

We are delighted to introduce our latest Analyst Emerging Investigator, Peng Miao!

Dr Peng Miao received his BS and MS degrees from School of Life Sciences at Nanjing University in 2008 and 2011. Afterwards, he received his PhD degree from University of Chinese Academy of Sciences in Biophysics. In 2017, he became a Professor at Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences (CAS). He has published over 100 peer-reviewed papers with an H-index of 21 (Web of Science), authored 15 patents and 2 books. He has received numerous awards and honours, including Fellow of the Royal Society of Chemistry (FRSC), Top 1% of Highly Cited Authors (RSC), CAS President’s Award (Chinese Academy of Sciences), and Science and Technology Award (China Association for Instrumental Analysis). His current research is focused on DNA nanotechnology based bioanalytical chemistry

 

Read Peng Miao’s Emerging Investigator Series paper “Ultrasensitive electrochemical detection of miRNA based on DNA strand displacement polymerization and Ca2+-dependent DNAzyme cleavage” and find out more about him in the interview below:

 

Your recent Emerging Investigator Series paper focuses on an ultrasensitive electrochemical biosensor for miRNA evaluation. How has your research evolved from your first article to this most recent article?
My first article is about the fabrication of an electrochemical biosensor for the detection of glutathione, which is amplified by DNA modified gold nanoparticles (Biosensors and Bioelectronics, 2009, 3347). Later, I was encouraged to develop more efficient signal amplification strategies aided by bottom-up or top-down DNA assembly. After nearly ten years’ efforts, I have developed a series of ultrasensitive biosensors for the detection of different biomolecules including the most recent article, in which strand displacement polymerization and DNAzyme cleavage cycles are involved for dual amplified detection of miRNA.

What aspect of your work are you most excited about at the moment?
DNA is nature’s choice for storing and transmitting genetic information, which is also an excellent nanoscale material to construct bio-architectures for analytical purposes. Taking advantages of the properties like predictable Watson-Crick base pairing and addressability, bottom-up and top-down design principles can be achieved to sensitively identify targets or study molecular interactions, which are really exciting.

In your opinion, what are the most promising applications of this miRNA detection method?
This paper reported an ultrasensitive electrochemical miRNA sensing method with cascade signal amplification. It is capable of monitoring miRNA levels in cells without sample enrichment in a highly selective manner. Therefore, this method could find potential practical applications in miRNA related biological researches. It could also be used as a candidate to replace qRT-PCR for clinical diagnosis.

What do you find most challenging about your research?
The most challenge is to accurately control multiple DNA assembly events at the nano-bio interface.

How do you spend your spare time?
Playing badminton and electronic sports.

Which profession would you choose if you were not a scientist?
Maybe a programmer.

Can you share one piece of career-related advice or wisdom with other early career scientists?
In the early career, scientists should scrupulously choose their research areas and their research work should not be decentralized.

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