Archive for April, 2014

HOT articles in Analyst

Take a look at our new HOT articles just published in Analyst and free for you for the next couple of weeks: Graphical abstract: An electrochemiluminescent microRNA biosensor based on hybridization chain reaction coupled with hemin as the signal enhancer

Fabrication of disposable electrochemical devices using silver ink and office paper
W. R. de Araujo and T. R. L. C. Paixão
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN00097H, Paper

A hybrid paper and microfluidic chip with electrowetting valves and colorimetric detection
Fei He, Jeff Grimes, Samuel D. Alcaine and Sam R. Nugen
Analyst, 2014, Advance Article
DOI: 10.1039/C3AN01516E, Paper

An electrochemiluminescent microRNA biosensor based on hybridization chain reaction coupled with hemin as the signal enhancer
Pu Zhang, Xiaoyan Wu, Yaqin Chai and Ruo Yuan
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN00284A, Paper

Investigating drug induced changes in single, living lymphocytes based on Raman micro-spectroscopy
Iwan W. Schie, Lucas Alber, Amy L. Gryshuk and James W. ChanGraphical abstract: Characterization of biofluids prepared by sessile drop formation
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN00250D, Paper

Single vs. two-photon microscopy for label free intrinsic tissue studies in the UV light region
Vitalijs Zubkovs, Frédéric Jamme, Slavka Kascakova, Franck Chiappini, François Le Naour and Matthieu Réfrégiers
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN00203B, Communication

Characterization of biofluids prepared by sessile drop formation
Karen A. Esmonde-White, Francis W. L. Esmonde-White, Michael D. Morris and Blake J. Roessler
Analyst, 2014, Advance Article
DOI: 10.1039/C3AN02175K, Paper

DNA hybridization detection with 100 zM sensitivity using piezoelectric plate sensors with an improved noise-reduction algorithm
Ceyhun E. Kirimli, Wei-Heng Shih and Wan Y. Shih
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN00215F, Paper

Detection of zeptomole quantities of nonfluorescent molecules in a 101 nm nanochannel by thermal lens microscopy
T. H. H. Le, K. Mawatari, H. Shimizu and T. Kitamori
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN00344F, Paper Graphical abstract: Detection of zeptomole quantities of nonfluorescent molecules in a 101 nm nanochannel by thermal lens microscopy

Microfluidic-SERS devices for one shot limit-of-detection
Donghyuk Kim, Antonio R. Campos, Ashish Datt, Zhe Gao, Matthew Rycenga, Nathan D. Burrows, Nathan G. Greeneltch, Chad A. Mirkin, Catherine J. Murphy, Richard P. Van Duyne and Christy L. Haynes
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN00357H, Paper

Touch spray mass spectrometry for in situ analysis of complex samples
Kevin S. Kerian, Alan K. Jarmusch and R. Graham Cooks
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN00548A, Paper

Criteria for sensitivity enhancement by compressed sensing: practical application to anisotropic NAD 2D-NMR spectroscopy
Krzysztof Kazimierczuk, Olivier Lafon and Philippe Lesot
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN00381K, Paper

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Lights! Camera! ePetri!

Tracking the activity of viruses has never been so easy thanks to the latest development from Chao Han and Changhuei Yang, researchers at the California Institute of Technology, USA.  The duo has developed ePetri, a high performance imaging platform capable of monitoring the formation of viral plaques, an event that occurs when a virus infects a host cell. Unlike conventional plaque assays, ePetri provides high resolution, time-lapse imaging for precise monitoring of the dynamics of viral plaque formation and growth. In addition to enabling better analysis of viral behaviour, the capabilities of ePetri may also facilitate future applications in antiviral drug discovery. Learn more by accessing the link below. 

ePetri Instrument for Viral Plaque Analysis

ePetri Instrument for Viral Plaque Analysis

 

Viral plaque analysis on a wide field-of-view, time-lapse, on-chip imaging platform 

Chao Han and Changhuei Yang 

Analyst, 2014, Advance Article

DOI: 10.1039/C3AN02323K, Paper

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Point-of-Care Paper Based Rapid Allergy Diagnostics

Recent surveys from Allergy UK have shown that the rates of allergy are increasing throughout the world, affecting up to 30-35 % of people at some point during their lives, in some cases with fatal consequences. In vitro testing of specific Immunoglobin E (IgE) reactivities is thought to be able to significantly improve diagnostic accuracy and management in primary care. IgE plays a significant role in allergic conditions. Current methods for the sensitive and accurate detection of specific IgE reactivities are expensive; require significant sample preparation and investment in equipment. There is a need to provide a cheap, rapid, sensitive and specific test for IgE reactivities.

In a recent HOT article, a group of Swedish and Dutch Scientists describe a paper based lateral flow microarray for rapid allergy diagnostics. One of the authors, Jesper Gantelius of the Science for Life Laboratory, highlights “There is a rapid worldwide increase in atopic disorders and asthma without a clear understanding of the underlying cause. We have developed a paper-based microarray assay that could be used to rapidly and cost-efficiently evaluate a large number of specific IgE sensitisation’s in a primary care setting. The device may come to aid doctors in the personalised management of individual patients, as well as allow public health bodies to gain a better insight into the rapid increase of allergy-related conditions.”

The group, led by Prof. Helene Andersson Svahn, describe exciting research that was able to detect the responses of 15 specific IgE responses from 35 clinical serum samples with an inter-assay variability of 12 % revealing good general agreement with a current multiplexed array-based methodology. Interestingly this process is fully scalable and all that is required for data feedback is a consumer-grade flatbed scanner or smartphone camera enabling point-of-care diagnostics.

A lateral flow paper microarray for rapid allergy point of care diagnostics

Thiruppathiraja ChinnasamyLoes I. Segerink, Mats Nystrand, Jesper Gantelius and Helene Andersson Svahn

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Analytical Tools for Cutting-edge Metabolomics – April 30th

Analytical Tools for Cutting-edge Metabolomics – a joint meeting of the Analytical Division of the RSC and the International Metabolomics Society

Analytical chemistry has been one of the driving forces behind the development of metabolomics research over the past decade. The conference will bring together exceptional scientists for a program consisting of plenary and invited talks, posters, as well as an oral session devoted to early career researchers. It will be an excellent opportunity for analytical chemists to learn more about metabolomics and its application, and for metabolomics scientists to improve their knowledge of cutting-edge bioanalytical tools.

More information can be found here.

Representatives of the Royal Society of Chemistry will be in attendance to answer your questions about the Analytical Division, and the Analytical Journals Portfiolio in Publishing. We hope we see you there.

Date: 30 April 2014, 09:30 – 16:45
Location: Burlington House, London
Contact: Mr Brian Woodget
Email: bwoodget1@sky.com
Tel: 01438 880286


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HOT articles in Analyst

Take a look at our new HOT articles just published in Analyst and free for you for the next couple of weeks: Graphical abstract: Electrochemiluminescence resonance energy transfer between graphene quantum dots and gold nanoparticles for DNA damage detection

Electrochemiluminescence resonance energy transfer between graphene quantum dots and gold nanoparticles for DNA damage detection
Qian Lu, Wei Wei, Zhenxian Zhou, Zhixin Zhou, Yuanjian Zhang and Songqin Liu
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN00020J, Paper

A lateral flow paper microarray for rapid allergy point of care diagnostics
Thiruppathiraja Chinnasamy, Loes I. Segerink, Mats Nystrand, Jesper Gantelius and Helene Andersson Svahn
Analyst, 2014, Advance Article
DOI: 10.1039/C3AN01806G, Paper

Nanoparticles in sensing applications: on what timescale do analyte species adsorb on the particle surface?
Enno Kätelhön and Richard G. Compton
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN00363B, Paper

The use of EEM fluorescence data and OPLS/UPLS-DA algorithm to discriminate between normal and cancer cell lines: a feasibility study
Ana Carolina de Oliveira Neves, Raimundo Fernandes de Araújo Júnior, Ana Luiza Cabral de Sá Leitão Oliveira, Aurigena Antunes de Araújo and Kássio Michell Gomes de Lima Graphical abstract: A lateral flow paper microarray for rapid allergy point of care diagnostics
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN00296B, Paper

Enhancing permanganate chemiluminescence detection for the determination of glutathione and glutathione disulfide in biological matrices
Zoe M. Smith, Jessica M. Terry, Neil W. Barnett, Laura J. Gray, Dean J. Wright and Paul S. Francis
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN00255E, Paper

Mass spectrometric investigation of the role of the linking polypeptide chain in DNA polymerase I
Taeho Yeom, Jungyoon Lee, Seonghyun Lee, Sunah Kang, Kyung Rok Kim, Byungwoo Han, Hyun Soo Lee and Kyubong Jo
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN00107A, Paper

Optimizing detection of RDX vapors using designed experiments for remote sensing
Robert G. Ewing, Alejandro Heredia-Langner and Marvin G. WarnerGraphical abstract: Nanoparticles in sensing applications: on what timescale do analyte species adsorb on the particle surface?
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN00125G, Paper

Mixed hydrogel bead-based tumor spheroid formation and anticancer drug testing
Yaolei Wang and Jinyi Wang
Analyst, 2014, Advance Article
DOI: 10.1039/C4AN00015C, Paper

Carbon nanobelts as a novel sensing platform for fluorescence-enhanced DNA detection
Xuping Sun, Zhicai Xing, Rui Ning, Abdullah M. Asiri and Abdullah Y. Obaid
Analyst, 2014, Advance Article
DOI: 10.1039/C3AN02364H, Communication

To view these article for free, please register for a free RSC account here

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Poster prize winners at the 11th Uppsala Conference

Congratulations to the Analyst Poster Prize winners at the recent 11th Uppsala Conference.

 Christopher Andrew Wootton
University of Warwick, UK

 Heidelinde Glasner
University of Innsbruck, Austria

    
 

Owen Samuel Skinner
Northwestern University, USA

 

 

Well done Christopher, Heidelinde and Owen!

Thanks to the conference organisers Dr Thomas Müller and Dr Kathrin Breuker as well as Editorial Board Member Professor Evan Williams who presented the poster prizes. We hope you enjoyed the 11th Uppsala Conference on Electron Capture and Transfer Dissociation (UppCon 2014) held in Obergurgl, Austria.

   
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Analytical tools made from ordinary office paper

Commonplace equipment can turn office paper into cheap, portable and disposable electrochemical devices that are ideal for using in remote locations.

The simple sensors from William de Araujo and Thiago da Paixão at the University of São Paulo, Brazil combine silver ink with ordinary office paper. Office paper is 97% cheaper than the chromatography paper commonly used in cutting-edge paper-based sensors.

To read the full article by Hazel Neighbour, please go to Chemistry World.

Fabrication of disposable electrochemical devices using silver ink and office paper
William Araujo and Thiago Regis Longo Cesar Paixão
Analyst, 2014, Accepted Manuscript
DOI: 10.1039/C4AN00097H, Paper

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