Ming-jie Yin and others from The Hong Kong Polytechnic University in China have made the latest stride towards development of label-free fiber-optic biosensors for DNA detection.
Their new design involves fabrication of a DNA sensor as part of a thin sensing film on the surface of a thin-core fiber modal interferometer (TCFMI) to measure differences in refractive-index upon detection of target DNA sequences. The research team makes use of a layer-by-layer self-assembly approach, which enables controlled tunability in preparation of the sensing film.
Unlike many other reported fiber-optic biosensing methods, this current strategy confers the advantages of high detection sensitivity, lower cost and ease in preparation.
Read more about the latest discovery by accessing the link below. This article will be free to read until March 6th.
Label-free, disposable fiber-optic biosensors for DNA hybridization detection
Ming-jie Yin , Chuang Wu , Li-yang Shao , Wing Kin Edward Chan , A. Ping Zhang , Chao Lu and Hwa-yaw Tam
Analyst, 2013, Advance Article