Archive for October, 2012

HOT articles in Analyst

Cover 1Take a look below at some wonderful HOT articles we’ve recently published this month in Analyst. There are papers covering a large variety of fields, including SPR-based analysis, platinum nanoparticles, and cancer cell research. These HOT papers will be free to read for two weeks.

Fluorescent polymer-based post-translational differentiation and subtyping of breast cancer cells
Michael D. Scott ,  Rinku Dutta ,  Manas K. Haldar ,  Anil Wagh ,  Thomas R. Gustad ,  Benedict Law ,  Daniel L. Friesner and Sanku Mallik
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN35877H

Aptamer carbon nanodot sandwich used for fluorescent detection of protein
Bailu Xu ,  Chuanqi Zhao ,  Weili Wei ,  Jinsong Ren ,  Daisuke Miyoshi ,  Naoki Sugimoto and Xiaogang Qu
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN36174D

Microfluidic integration of Western blotting is enabled by electrotransfer-assisted sodium dodecyl sulfate dilution
Chenlu Hou and Amy E. Herr
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN36033K

Affinity surface-assisted laser desorption/ionization mass spectrometry for peptide enrichment
Yannick Coffinier ,  Nhung Nguyen ,  Hervé Drobecq ,  Oleg Melnyk ,  Vincent Thomy and Rabah Boukherroub
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN35803D

Protection and functionalisation of silver as an optical sensing platform for highly sensitive SPR based analysis
Gowri Manickam ,  Ram Gandhiraman ,  Rajani K. Vijayaraghavan ,  Laura Kerr ,  Colin Doyle ,  David E. Williams and Stephen Daniels
Analyst, 2012,137, 5265-5271
DOI: 10.1039/C2AN35826C

A terbium(III)-organic framework for highly selective sensing of cytidine triphosphate
Xi Juan Zhao ,  Rong Xing He and Yuan Fang Li
Analyst, 2012,137, 5190-5192
DOI: 10.1039/C2AN36188D

Platinum nanoparticles intermediate layer in solid-state selective electrodes
Beata Paczosa-Bator ,  Leszek Cabaj ,  Robert Piech and Krzysztof Skupień
Analyst, 2012,137, 5272-5277
DOI: 10.1039/C2AN35933B

Nanopatterned submicron pores as a shield for nonspecific binding in surface plasmon resonance-based sensing
Sabina Rebe Raz ,  Gerardo R. Marchesini ,  Maria G. E. G. Bremer ,  Pascal Colpo ,  Cesar Pascual Garcia ,  Guido Guidetti ,  Willem Norde and Francois Rossi
Analyst, 2012,137, 5251-5259
DOI: 10.1039/C2AN35521C

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2p or not 2p: that is the title…

…of a recent paper from the RSC’s Analyst, followed by the tagline ‘tuppence-based SERS for the detection of illicit materials’.

In the paper, scientists from Manchester explain how they used a UK two pence piece (a.k.a. tuppence) to do some drug detection work!

Royston Goodacre and team from University of Manchester altered the surface of a copper two pence piece with silver to make it suitable for the vibrational spectroscopic technique surface-enhanced Raman scattering (SERS), which they then used to differentiate between the drugs: 4-methylmethcathinone (mephedrone), 5,6-methylenedioxy-2-aminoindane (MDAI) and 3,4-methylenedioxy-N-methylamphetamine (MDMA).

Photo

To read the full article please visit Chemistry World

2p or not 2p: Tuppence-based SERS for the detection of illicit materials
Samuel Mabbott, Axel Eckmann, Cinzia Casiraghi and Royston Goodacre
Analyst, 2012, Accepted Manuscript
DOI: 10.1039/C2AN35974J, Paper

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Analyst Issue 22 now online!

The latest issue of Analyst has now gone online, so take a look at the wonderful covers and the work that inspired them!

Oustide front cover, Analyst, Issue 22, 2012

Kranz et al., Analyst, 2012, 137, 5208

On the front cover we have an image from Editorial Board member Boris Mizaikoff, Christine Kranz and colleagues from the University of Ulm. Their group designed a miniaturized cell stretching device for mechanically stimulating living cells at physiologically relevant levels applicable to a wide variety of adherent cell types. Click on the link below to read more.

Combining atomic force-fluorescence microscopy with a stretching device for analyzing mechanotransduction processes in living cells
E. Hecht, P. Knittel, E. Felder, P. Dietl, B. Mizaikoff and C. Kranz
Analyst, 2012, 137, 5208-5214
DOI: 10.1039/C2AN36001B

Inside front cover, Analyst, Issue 22, 2012

Wong et al., Analyst, 2012, 137, 5215

Our inside front cover comes from Pak Kin Wong, The University of Arizona, USA, who together with colleagues reports on a hybrid electrokinetic technique that can manipulate mammalian cells in physiological fluids. Cells can be adjusted for separation and focusing applications. Click below to find out more.

Electrokinetic focusing and separation of mammalian cells in conductive biological fluids
Jian Gao, Reza Riahi, Mandy L. Y. Sin, Shufeng Zhang and Pak Kin Wong
Analyst, 2012, 137, 5215-5221
DOI: 10.1039/C2AN35707K

Back cover, Analyst, Issue 22, 2012

El-Safty et al., Analyst, 2012, 137, 5278

On the back cover, we showcase research feature from the Sherif A. El-Safty Laboratory, National Institute for Materials Science, Japan. Uniform, 3D mesopore, ordered monoliths lead to tailored mesocaptor design of heavy metals. A multi-capture system enabled optical separation, and detection of ultra-trace level of ions in drinking water. This captor would develop a simple technique for wastewater treatment and management.

Optical mesosensors for monitoring and removal of ultra-trace concentration of Zn(II) and Cu(II) ions from water
Sherif A. El-Safty, M. A. Shenashen, M. Ismael, M. Khairy and Md. R. Awual
Analyst, 2012, 137, 5278-5290
DOI: 10.1039/C2AN35484E

All of these cover articles will be free to read for 6 weeks.

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Surface-enhanced Raman scattering-active gold nanoparticles modified with a monolayer of silver film

Surface-enhanced Raman scattering-active gold nanoparticles modified with a monolayer of silver film

Liu et al., Analyst, 2012, 137, 4943

By Jennifer A. Dougan, Imperial College London, Web Writer

In a HOT new Analyst article, Yu-Chuan Liu and collaborators from Taipei Medical University, Taiwan, have reported the preparation of highly sensitive substrates for surface enhanced Raman scattering (SERS) spectroscopy.  The surface enhancement of Raman scattering relies on the use of suitably roughened metal surfaces.  Liu et al. used electrochemical underpotential deposition (UPD) of silver onto gold nanoparticles on a platinum substrate via sonoelectrochemical deposition-dissolution cycles to prepare the SERS active substrates.  The use of Rhodamine 6 G as a model analyte revealed that the UPD silver on gold substrates show marked SERS enhancement when compared with bulk silver coating or gold nanoparticles alone [a limit of detection of 2 × 10-14 M is reported].  SERS is now used as a detection technique across a range of disciplines and the simple preparation of ultra-sensitive substrates will, potentially, have wide-ranging impact. This paper will be free to read until Oct 29th.

Surface-enhanced Raman scattering-active gold nanoparticles modified with a monolayer of silver film
Chun-Chao Chang, Kuang-Hsuan Yang, Yu-Chuan Liu, Chung-Chin Yu and Yi-Hao Wu
Analyst, 2012, 137, 4943-4950
DOI: 10.1039/C2AN35912J

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Point of Care Diagnostics Workshop – 4 Dec 2012, London UK

Point-of-Care Diagnostics Workshop
4 December 2012, Burlington House, London, UK

Point-of-care diagnostic (POC) test devices provide rapid results on an ever expanding range of medical tests, helping to streamline healthcare and improve clinical outcomes. Research on microfluidics for POC applications has increased markedly in recent years, fuelled by an interest in constructing field-deployable analytical instruments. The interest in POC microfluidic-based devices has been intense and has cut across all major disciplines in lab-on-a-chip research, including engineering (biomedical, chemical, electrical, and mechanical), chemistry, and physics.  For further details please visit the website.

Point of Care Diagnostics Workshop - 4 Dec 2012, London UK

Abstract submission deadline: 31 October 2012. Abstract submission is now available online.

Application deadline: 31 October 2012. Application is now available online.

Workshop format
The aims of this Joint Biochemical Society/Royal Society of Chemistry workshop are to provide participants with a better understanding of the challenges involved in translating research outputs into application and to help encourage collaborations with industry and clinicians on POC. The workshop will bring together researchers who work at the interface between biology, chemistry and the wider life and medical sciences. Participants will be encouraged to participate in oral presentations, as well as in discussion groups intended to help move this area forward.

Speakers
Dr Ana Alfirevic, University of Liverpool, UK
Professor Andrew de Mello, ETH Zürich, Switzerland

Attendance is by application only and will be FREE of charge for Biochemical Society and Royal Society of Chemistry members.

This workshop is the fourth of a series entitled “Analytical Tools for the Life Sciences”, a collaborative project between the Biochemical Society and Royal Society of Chemistry members.

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Mastering Big Ideas for Small Devices

By Pui Sai Lau, Web Writer

Optimization of multiplexed PCR on an integrated microfluidic forensic platform for rapid DNA analysis

Zenhausern et al., Analyst, 2012, Advance Article

Miniature. Fast. Automated. User-friendly. Low cost. These are characteristics that describe the ideal analytical device for many applications such as point-of-care diagnostics. Rapid advancement has been made in microfluidics and micro total analysis systems over the past twenty years, which has resulted in substantial improvements to common procedures like PCR analysis. Frederic Zenhausern and colleagues from the University of Arizona, USA, have made further progress by optimizing the efficiency of multiplexed PCR on an microfluidic device to yield high-quality DNA analysis. Find out all the details by accessing the link below, it will be free to read until Oct 19th:

Optimization of multiplexed PCR on an integrated microfluidic forensic platform for rapid DNA analysis
Matthew D. Estes, Jianing Yang, Brett Duane, Stan Smith, Carla Brooks, Alan Nordquist and Frederic Zenhausern
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN35768B

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HOT articles in Analyst this September

An coverTake a look below at some wonderful HOT articles we’ve recently published this month in Analyst. There are papers covering a large variety of fields, including metabolomics, sample preparation, fluorimetry and electrochemiluminescent sensing. These HOT papers will be free to read for two weeks.

Selective fluorometric detection of pyrophosphate by 3-hydroxyflavone-diphenyltin(IV) complex in aqueous micellar medium
Raul Villamil-Ramos ,  Víctor Barba and Anatoly K. Yatsimirsky
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN35999E

Morphological analysis of vibrational hyperspectral imaging data
Jacob Filik ,  Abigail V. Rutter ,  Josep Sulé-Suso and Gianfelice Cinque
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN35914F

Layer-by-layer self-assembled graphene oxide/silica microsphere composites as stationary phase for high performance liquid chromatography
Xiaojing Liang ,  Shujuan Liu ,  Xinwang Song ,  Yangwen Zhu and Shengxiang Jiang
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN36091H

Intramolecular vibrational coupling in water molecules revealed by compatible multiple nonlinear vibrational spectroscopic measurements
Shuji Ye ,  Sulan Ma ,  Feng Wei and Hongchun Li
Analyst, 2012,137, 4981-4987
DOI: 10.1039/C2AN35684H

Fenton’s reagent-tuned DNA-templated fluorescent silver nanoclusters as a versatile fluorescence probe and logic device
Li-Pei Zhang ,  Xiao-Xing Zhang ,  Bo Hu ,  Li-Ming Shen ,  Xu-Wei Chen and Jian-Hua Wang
Analyst, 2012,137, 4974-4980
DOI: 10.1039/C2AN36049G

Sensitive spectrofluorometry of cellular prion protein based on the on–off interaction between fluorescent dye-labelled aptamers and multi-walled carbon nanotubes
Lei Zhan ,  Li Peng ,  Yan Yu ,  Shu Jun Zhen and Cheng Zhi Huang
Analyst, 2012,137, 4968-4973
DOI: 10.1039/C2AN35924C

One-step immobilization of Ru(bpy)32+ in a silica matrix for the construction of a solid-state electrochemiluminescent sensor with high performance
Jing Li ,  Fang-Nan Xiao and Xing-Hua Xia
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN35980D

Implementation of a semi-automated strategy for the annotation of metabolomic fingerprints generated by liquid chromatography-high resolution mass spectrometry from biological samples
Frédérique Courant ,  Anne-Lise Royer ,  Sylvain Chéreau ,  Marie-Line Morvan ,  Fabrice Monteau ,  Jean-Philippe Antignac and Bruno Le Bizec
Analyst, 2012,137, 4958-4967
DOI: 10.1039/C2AN35865D

An cover 2

Applications of reversible covalent chemistry in analytical sample preparation
David Siegel
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN35697J

Tactile multisensing on flexible aluminum nitride
Simona Petroni ,  Francesco Guido ,  Bruno Torre ,  Andrea Falqui ,  Maria Teresa Todaro ,  Roberto Cingolani and Massimo De Vittorio
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN36015B

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Top ten most accessed articles in August

This month sees the following articles in Analyst that are in the top ten most accessed:-

Gold nanoparticles-based nanoconjugates for enhanced enzyme cascade and glucose sensing 
Dongdong Zeng ,  Weijie Luo ,  Jiang Li ,  Huajie Liu ,  Hongwei Ma ,  Qing Huang and Chunhai Fan  
Analyst, 2012,137, 4435-4439 DOI: 10.1039/C2AN35900F  

A BODIPY derivative as a highly selective “Off–On” fluorescent chemosensor for hydrogen sulfate anion 
Qian Li ,  Yong Guo and Shijun Shao  
Analyst, 2012,137, 4497-4501 DOI: 10.1039/C2AN35904A  

A turn-on and reversible fluorescence sensor for zinc ion 
Hsiang-Yi Lin ,  Pi-Yun Cheng ,  Chin-Feng Wan and An-Tai Wu  
Analyst, 2012,137, 4415-4417 DOI: 10.1039/C2AN35752F  

Upconversion nanoparticles in biological labeling, imaging, and therapy 
Feng Wang ,  Debapriya Banerjee ,  Yongsheng Liu ,  Xueyuan Chen and Xiaogang Liu  
Analyst, 2010,135, 1839-1854 DOI: 10.1039/C0AN00144A  

Development of a pH-activatable fluorescent probe and its application for visualizing cellular pH change 
Rong Huang ,  Shengyong Yan ,  Xiaolong Zheng ,  Fengling Luo ,  Minggang Deng ,  Boshi Fu ,  Yijie Xiao ,  Xi Zhao and Xiang Zhou  
Analyst, 2012,137, 4418-4420 DOI: 10.1039/C2AN35671F  

A simple colorimetric device for rapid detection of Hg2+ in water 
Tingxiu Ye ,  Chunyan He ,  Yanqin Qu ,  Zhuo Deng ,  Yaqi Jiang ,  Meijin Li and Xi Chen  
Analyst, 2012,137, 4131-4134 DOI: 10.1039/C2AN35422E  

BSA-templated MnO2 nanoparticles as both peroxidase and oxidase mimics 
Xing Liu ,  Qi Wang ,  Huihui Zhao ,  Lichun Zhang ,  Yingying Su and Yi Lv  
Analyst, 2012,137, 4552-4558 DOI: 10.1039/C2AN35700C  

CTAB-capped Mn-doped ZnS quantum dots and label-free aptamer for room-temperature phosphorescence detection of mercury ions 
Wan Yi Xie ,  Wei Tao Huang ,  Hong Qun Luo and Nian Bing Li  
Analyst, 2012,137, 4651-4653 DOI: 10.1039/C2AN35777A  

Functionalized shell-isolated nanoparticle-enhanced Raman spectroscopy for selective detection of trinitrotoluene 
Kai Qian ,  Honglin Liu ,  Liangbao Yang and Jinhuai Liu  
Analyst, 2012,137, 4644-4646 DOI: 10.1039/C2AN35947B  

Electrochemical analysis based on nanoporous structures 
Sangyun Park ,  Hee Chan Kim and Taek Dong Chung  
Analyst, 2012,137, 3891-3903 DOI: 10.1039/C2AN35294J  

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to Analyst? Then why not submit to us today or alternatively email us  your suggestions.

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HOT articles in Issue 21 of Analyst

It’s a bumper list of HOT articles that we have in this current issue of Analyst!

Outside front cover, Analyst, Issue 21, 2012

Chung et al., Analyst, 2012, 137, 4921

We have our cover article from Yu-Chang Tyan and Tze-Wen Chung and their study on a proposed a new approach for the detection of proteins to assess the response of fibroblasts to a material surface.

Assessing the responses of cellular proteins induced by hyaluronic acid-modified surfaces utilizing a mass spectrometry-based profiling system: Over-expression of CD36, CD44, CDK9, and PP2A
Ming-Hui Yang, Shiang-Bin Jong, Chi-Yu Lu, Yu-Fen Lin, Pei-Wen Chiang, Yu-Chang Tyan and Tze-Wen Chung
Analyst, 2012, 137, 4921-4933
DOI: 10.1039/C2AN35368G

We also have a number of exciting papers on a range of topics including

Tracing nanoparticles in vivo: a new general synthesis of positron emitting metal oxide nanoparticles by proton beam activation
Carlos Pérez-Campaña, Vanessa Gómez-Vallejo, Abraham Martin, Eneko San Sebastián, Sergio E. Moya, Torsten Reese, Ronald F. Ziolo and Jordi Llop
Analyst, 2012, 137, 4902-4906
DOI: 10.1039/C2AN35863H

Surface-enhanced Raman scattering-active gold nanoparticles modified with a monolayer of silver film
Chun-Chao Chang, Kuang-Hsuan Yang, Yu-Chuan Liu, Chung-Chin Yu and Yi-Hao Wu
Analyst, 2012, 137, 4943-4950
DOI: 10.1039/C2AN35912J

Tracing nanoparticles in vivo: a new general synthesis of positron emitting metal oxide nanoparticles by proton beam activation

Llop et al., Analyst, 2012, 137, 4902

A simultaneous voltammetric temperature and humidity sensor
Linhongjia Xiong, Ai M. Fletcher, Stephen G. Davies, Sarah E. Norman, Christopher Hardacre and Richard G. Compton
Analyst, 2012, 137, 4951-4957
DOI: 10.1039/C2AN35939A

Implementation of a semi-automated strategy for the annotation of metabolomic fingerprints generated by liquid chromatography-high resolution mass spectrometry from biological samples
Frédérique Courant, Anne-Lise Royer, Sylvain Chéreau, Marie-Line Morvan, Fabrice Monteau, Jean-Philippe Antignac and Bruno Le Bizec
Analyst, 2012, 137, 4958-4967
DOI: 10.1039/C2AN35865D

Sensitive spectrofluorometry of cellular prion protein based on the on–off interaction between fluorescent dye-labelled aptamers and multi-walled carbon nanotubes
Lei Zhan, Li Peng, Yan Yu, Shu Jun Zhen and Cheng Zhi Huang
Analyst, 2012, 137, 4968-4973
DOI: 10.1039/C2AN35924C

Fenton’s reagent-tuned DNA-templated fluorescent silver nanoclusters as a versatile fluorescence probe and logic device

Chen & Wang et al., Analyst, 2012, 137, 4974

Fenton’s reagent-tuned DNA-templated fluorescent silver nanoclusters as a versatile fluorescence probe and logic device
Li-Pei Zhang, Xiao-Xing Zhang, Bo Hu, Li-Ming Shen, Xu-Wei Chen and Jian-Hua Wang
Analyst, 2012, 137, 4974-4980
DOI: 10.1039/C2AN36049G

Intramolecular vibrational coupling in water molecules revealed by compatible multiple nonlinear vibrational spectroscopic measurements
Shuji Ye, Sulan Ma, Feng Wei and Hongchun Li
Analyst, 2012, 137, 4981-4987
DOI: 10.1039/C2AN35684H

These HOT papers will be free to read until Oct 19th.

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Biological fate of nanoparticles in the body

Metal oxide nanoparticles are currently used for a variety of applications including diagnostics and biomedicine. However, these nanoparticles are extremely difficult to detect and measure once they are distributed in a biological system. Now, Spanish scientists have developed a novel way for measuring their biodistribution.

Positron emission tomography image of the 18F-labelled metal oxide nanoparticles in vivo

Positron emission tomography image of the 18F-labelled metal oxide nanoparticles in vivo

Until now, labelling techniques have relied upon the functionalisation of the surface of the nanoparticle, which may alter the behaviour of the nanoparticle. Jordi Llop at the Centre for Cooperative Research in Biomaterials-CIC biomaGUNE, in San Sebastian, and co-workers, have developed a unique approach to avoid this by preparing metal oxides enriched with 18O. The 18O is incorporated to allow for more efficient cyclotron-mediated conversion to the radioactive 18F which can then be traced in vivo.

To read the full article please visit Chemistry World

Tracing nanoparticles in vivo: a new general synthesis of positron emitting metal oxide nanoparticles by proton beam activation
Carlos Pérez-Campaña ,  Vanessa Gómez-Vallejo ,  Abraham Martin ,  Eneko San Sebastián ,  Sergio E. Moya ,  Torsten Reese ,  Ronald F. Ziolo and Jordi Llop
Analyst, 2012,137, 4902-4906
DOI: 10.1039/C2AN35863H

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