HOT article: Studying enzyme activity

Smith et al., Analyst, 2012, Advance Article

By Jennifer A. Dougan, Imperial College London, Web Writer

Deficiencies of aldehyde dehydrogenase (ALDH) enzymes have been linked to Parkinson’s disease, alcoholic liver disease and Alzheimer’s disease amongst others. David Smith and co-workers have been studying the activity of this class of enzyme in cell cultures by analysing the volatile components they produce by selected ion flow tube mass spectrometry (SIFT-MS). Click here to read more about this study, by the researchers from Keele University, and the opportunity to extend the scope of this methodology to other volatile components for drug screening and the prevention or treatment of disease.

A study of enzymatic activity in cell cultures via the analysis of volatile biomarkers
Thomas W. E. Chippendale, Bin Hu, Alicia J. El Haj and David Smith
Analyst, 2012, Advance Article
DOI: 10.1039/C2AN35815H

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